{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:14:09Z","timestamp":1780092849356,"version":"3.54.0"},"reference-count":48,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Granulomatose mit Polyangiitis ist eine seltene chronische rheumatologische Systemerkrankung, die mit einer Vaskulitis der kleinen und mittleren Gef\u00e4\u00dfe einhergeht. Am h\u00e4ufigsten betrifft sie die oberen Atemwege, die Lunge und die Nieren. Die Beschwerden sind unspezifisch, h\u00e4ufig beklagen die Patienten anfangs eine Nasenatmungsbehinderung, Borkenbildung in der Nase, Ulzera der Mundschleimh\u00e4ute oder Epistaxis. Nicht selten wird deshalb der Hals-Nasen-Ohren-Arzt zu Beginn der Krankheit hinzugezogen. Langfristig k\u00f6nnen schwerwiegende kardiale, renale oder pulmonale Komplikationen auftreten. Die \u00c4tiologie ist bis heute nicht komplett gekl\u00e4rt. Als Therapie wird eine Immunsuppression eingeleitet. Klinische und laborchemische Kontrollen sind lebenslang obligat.<\/jats:p>","DOI":"10.1055\/a-1580-7037","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T23:37:40Z","timestamp":1637019460000},"page":"112-119","source":"Crossref","is-referenced-by-count":1,"title":["Granulomatose mit Polyangiitis \u2013 Manifestationen im Kopf-Hals-Bereich"],"prefix":"10.1055","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0570-1776","authenticated-orcid":false,"given":"Kim Vanessa","family":"Steinke","sequence":"additional","affiliation":[{"name":"HNO, KRH Klinikum Nordstadt, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00fcrgen","family":"Welkoborsky","sequence":"additional","affiliation":[{"name":"HNO, KRH Klinikum Nordstadt, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides","volume":"65","author":"J C Jennette","year":"2013","journal-title":"Arthritis Rheum"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1002\/art.1780330807","article-title":"The American College of Rheumatology 1990 criteria for the classification of Wegener\u2019s granulomatosis","volume":"33","author":"R Y Leavitt","year":"1990","journal-title":"Arthritis Rheum"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/art.1780370206","article-title":"Nomenclature of systemic vasculitides. 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