{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:25:40Z","timestamp":1770956740076,"version":"3.50.1"},"reference-count":87,"publisher":"Georg Thieme Verlag KG","issue":"08","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This review focuses on the efficacy of herbal medicines for managing dyspepsia in humans and animals. Searches were conducted on the PubMed, Science Direct, and Medline databases, for publications in the last 3 years. In each database, the search terms used consisted of the 2 key terms describing the disorder and subtypes plus each of the terms relating to the therapy. The key terms used were \u201cnatural product\u201d and \u201cmedicinal plant\u201d in a cross-over with \u201cdyspepsia\u201d and \u201cfunctional dyspepsia\u201d (i.e., gastroprotection, Helicobacter pylori infection, prokinetic). We included all human and animal studies on the effects of herbal medicines reporting the key outcome of dyspepsia symptoms. Preclinical studies using critically validated models showed that most medicinal plants with gastroprotective action had antioxidant, anti-inflammatory, anti-apoptotic, and antisecretory effects. Moreover, several species displayed anti Helicobacter pylori and prokinetic efficacy. The\n\t\t\t\t\tdata availability of controlled clinical studies is currently minimal. The use of different methodologies and the minimal number of patients raise doubts about the effects of these preparations. Only adequate clinical trials with scientifically validated methods can determine whether different herbal medicines can be used as viable alternatives to the conventional pharmacological treatments used to control dyspepsia symptoms.<\/jats:p>","DOI":"10.1055\/a-1580-7782","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T22:49:42Z","timestamp":1630622982000},"page":"664-677","source":"Crossref","is-referenced-by-count":2,"title":["Herbal Medicines in the Treatment of Dyspepsia: An Overview"],"prefix":"10.1055","volume":"88","author":[{"given":"Thaise","family":"Boeing","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Graduate Program, University of Vale do Itaja\u00ed, Itaja\u00ed, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-5642","authenticated-orcid":false,"given":"Priscila","family":"de Souza","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Graduate Program, University of Vale do Itaja\u00ed, Itaja\u00ed, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa Mota","family":"da Silva","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Graduate Program, University of Vale do Itaja\u00ed, Itaja\u00ed, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-5098","authenticated-orcid":false,"given":"Arquimedes","family":"Gasparotto Junior","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFac), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1056\/NEJMra1501505","article-title":"Functional dyspepsia","volume":"373","author":"N J 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