{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T08:58:54Z","timestamp":1648630734513},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n               Gegenstand und Ziel Deoxynivalenol (DON) ist ein Mykotoxin, das von Pilzen der Fusarium spp. gebildet wird. Es verursacht Erbrechen, hat aber auch immunsuppressive Effekte, die sich auch lokal z.\u2005B. im Urogenitaltrakt auswirken k\u00f6nnen und damit fruchtbarkeitsrelevant sind. In diesem Beitrag wird \u00fcber ein DON-assoziiertes pathomorphologisches Bild des Urogenitaltrakts zusammen mit einer etwaigen mikrobiellen Besiedelung berichtet.<\/jats:p><jats:p>\n               Material und Methode Es wurden 19\u2005Genitaltrakte (Vagina, Zervix, Uterus, Eileiter und Ovarien) inklusive Harnblasen (n\u2005=\u200515) fruchtbarkeitsgest\u00f6rter Jung- und Altsauen unterschiedlicher Wurfnummern, die in den Jahren 2019\/20 aus 8\u2005Betrieben eingesandt wurden, pathomorphologisch untersucht. In 11 individuellen Galle- und 2\u2005Poolproben (2 bzw. 4\u2005Tiere) erfolgte die Bestimmung von DON und Zearalenon (ZEA) mittels Hochleistungsfl\u00fcssigkeitchromatografie. Zudem unterlagen 17\u2005Uteri und 12\u2005Harnblasen einer mikrobiologischen Untersuchung.<\/jats:p><jats:p>\n               Ergebnisse Fast alle Vaginae (n\u2005=\u200516), Cervices (n\u2005=\u200515), Uteri (n\u2005=\u200518) und viele Eileiter (n\u2005=\u200511) sowie Harnblasen (n\u2005=\u200511) waren \u00fcberwiegend mittel- bis hochgradig chronisch entz\u00fcndlich ver\u00e4ndert. In 17\u2005F\u00e4llen betraf die Entz\u00fcndung\u2005\u2265\u20052\u2005Organe. In der Regel lag eine Mischflora aus verschiedenen gramnegativen und grampositiven Bakterien vor, wobei E. coli, Streptococcus spp., Aeromonas spp. and Enterococcus spp. dominierten. Insgesamt 8 analysierte individuelle Galleproben und beide Poolproben waren DON-positiv (Konzentrationen 75,5 bis\u2005&gt;\u2005200,0\u2005\u00b5g\/l). In einigen der DON-positiven Proben wurde zeitgleich ZEA in geringen Konzentrationen nachgewiesen (6,57\u201321,20\u2005\u00b5g\/l).<\/jats:p><jats:p>\n               Schlussfolgerung und klinische Relevanz Es wird postuliert, dass DON Fruchtbarkeitsprobleme verursachen kann. Zur Abkl\u00e4rung empfehlen sich pathomorphologische Untersuchungen der Genitalorgane und Harnblase. Sind\u2005\u2265\u20052\u2005Organe chronisch entz\u00fcndlich ver\u00e4ndert und besteht zudem eine bakterielle Besiedelung des Uterus, ist eine Beteiligung von DON anzunehmen und durch eine Untersuchung im Gallensaft zu best\u00e4tigen.<\/jats:p>","DOI":"10.1055\/a-1580-8889","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T23:30:30Z","timestamp":1638574230000},"page":"384-391","source":"Crossref","is-referenced-by-count":0,"title":["Pathomorphologie und Mikrobiologie des Urogenitaltrakts fruchtbarkeitsgest\u00f6rter Sauen mit positivem Deoxynivalenol-Befund"],"prefix":"10.1055","volume":"49","author":[{"given":"Christian","family":"Baumann","sequence":"additional","affiliation":[{"name":"Agro-Vet GmbH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Schikore","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Klauentiere, Veterin\u00e4rmedizinische Fakult\u00e4t, Universit\u00e4t Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haukur L.","family":"Sigmarsson","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Klauentiere, Veterin\u00e4rmedizinische Fakult\u00e4t, Universit\u00e4t Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Sperling","sequence":"additional","affiliation":[{"name":"Ruminant and Swine Clinic, University of Veterinary and Pharmaceutical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Kauffold","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Klauentiere, Veterin\u00e4rmedizinische Fakult\u00e4t, Universit\u00e4t Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,12,3]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1055\/s-0038-1624034","article-title":"Nichtpuerperale Uteruserkrankungen beim Schwein. 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