{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:37:09Z","timestamp":1785760629800,"version":"3.56.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                    Topic and aims Canine atopic dermatitis (AD) is an inflammatory and pruritic skin disease and in most cases associated with IgE antibodies against environmental allergens. To date, the only causative therapeutic option is allergen immunotherapy (AIT). Offending allergens for AIT can be identified by intradermal testing (IDT) or serum allergen-specific IgE testing. The aim of the study was to evaluate positive IDT results considering the atopic dogs\u2019 clinical history.<\/jats:p><jats:p>\n                    Material and methods An IDT was performed on 48 atopic dogs and their owners completed a detailed questionnaire about the seasonal course of their pruritus. Results of IDT were correlated with the seasonal occurrence of pruritus.<\/jats:p><jats:p>\n                    Results The most common positive IDT reactions were observed to mite allergens (33.3\u201362.5\u2005%). Prevalence of positive reactions to individual tree, grass and weed pollen ranged between 8.3\u2005% and 25\u2005%. Moulds and epithelial allergens produced positive reactions in only 0\u20136.3\u2005%. A correlation between positive IDT reactions and course of pruritus could neither be found for perennial nor for seasonal allergens.<\/jats:p><jats:p>\n                    Conclusion The evaluation of IDT reactions may not be an optimal method for identification of clinically relevant allergens in canine AD.<\/jats:p><jats:p>\n                    Clinical relevance The results of this study emphasise the importance of considering clinical history in addition to allergy test results in the formulation of an allergen extract for desensitisation.<\/jats:p>","DOI":"10.1055\/a-1584-4965","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T22:33:53Z","timestamp":1634769233000},"page":"349-356","source":"Crossref","is-referenced-by-count":5,"title":["Clinical relevance of intradermal test results in atopic dogs"],"prefix":"10.1055","volume":"49","author":[{"given":"Stefanie","family":"Mallmann","sequence":"additional","affiliation":[{"name":"Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, LMU Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph J.","family":"Klinger","sequence":"additional","affiliation":[{"name":"Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, LMU Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Cla\u00dfen","sequence":"additional","affiliation":[{"name":"Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, LMU Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Wagner","sequence":"additional","affiliation":[{"name":"Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, LMU Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Klima","sequence":"additional","affiliation":[{"name":"Statistical consulting unit StaBLab, Department of Statistics, LMU Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Castelletti","sequence":"additional","affiliation":[{"name":"Statistical consulting unit StaBLab, Department of Statistics, LMU Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf S.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Small Animal Medicine Clinic, Centre for Clinical Veterinary Medicine, LMU Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0165-2427(01)00343-9","article-title":"The ACVD task force on canine atopic dermatitis: forewords and lexicon","volume":"81","author":"T Olivry","year":"2001","journal-title":"Vet Immunol Immunopathol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"194","DOI":"10.2460\/javma.241.2.194","article-title":"Current understanding of the pathophysiologic mechanisms of canine atopic dermatitis","volume":"241","author":"R Marsella","year":"2012","journal-title":"J Am Vet Med Assoc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/vde.12201","article-title":"Review: The role of antibodies, autoantigens and food allergens in canine atopic dermatitis","volume":"26","author":"C M Pucheu-Haston","year":"2015","journal-title":"Vet Dermatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/vde.12205","article-title":"Review: Lymphocytes, cytokines, chemokines and the T-helper 1-T-helper 2 balance in canine atopic dermatitis","volume":"26","author":"C M Pucheu-Haston","year":"2015","journal-title":"Vet Dermatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s12917-015-0515-5","article-title":"Canine atopic dermatitis: detailed guidelines for diagnosis and allergen identification","volume":"11","author":"P Hensel","year":"2015","journal-title":"BMC Vet Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s12917-015-0514-6","article-title":"Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA)","volume":"11","author":"T Olivry","year":"2015","journal-title":"BMC Vet Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1365-3164.2009.00784.x","article-title":"Interventions for atopic dermatitis in dogs: a systematic review of randomized controlled trials","volume":"21","author":"T Olivry","year":"2010","journal-title":"Vet Dermatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/j.1365-3164.2008.00727.x","article-title":"A review of allergen-specific immunotherapy in human and veterinary medicine","volume":"20","author":"C Loewenstein","year":"2009","journal-title":"Vet Dermatol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1111\/all.13464","article-title":"Allergen immunotherapy in people, dogs, cats and horses \u2013 differences, similarities and research needs","volume":"73","author":"R S Mueller","year":"2018","journal-title":"Allergy"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/s0165-2427(01)00313-0","article-title":"The ACVD task force on canine atopic dermatitis (XVII): intradermal testing","volume":"81","author":"A Hillier","year":"2001","journal-title":"Vet Immunol Immunopathol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/vde.12196","article-title":"Review: Clinical and histological manifestations of canine atopic dermatitis","volume":"26","author":"P Bizikova","year":"2015","journal-title":"Vet Dermatol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1365-3164.2009.00758.x","article-title":"A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis","volume":"21","author":"C Favrot","year":"2010","journal-title":"Vet Dermatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1751-0813.2000.tb11824.x","article-title":"Aero-allergens in canine atopic dermatitis in southeastern Australia based on 1000 intradermal skin tests","volume":"78","author":"R S Mueller","year":"2000","journal-title":"Aust Vet J"},{"key":"ref14","first-page":"55","article-title":"Canine allergic inhalant dermatitis: a review of 230 cases","volume":"172","author":"G H Nesbitt","year":"1978","journal-title":"J Am Vet Med Assoc"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/s0165-2427(99)00040-9","article-title":"Canine atopic dermatitis in Greece: clinical observations and the prevalence of positive intradermal test reactions in 91 spontaneous cases","volume":"69","author":"M N Saridomichelakis","year":"1999","journal-title":"Vet Immunol Immunopathol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/j.1365-3164.2012.01052.x","article-title":"Dust mite species in the households of mite-sensitive dogs with atopic dermatitis","volume":"23","author":"R Farmaki","year":"2012","journal-title":"Vet Dermatol"},{"issue":"05","key":"ref17","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1055\/s-0038-1622643","article-title":"Evaluierung von Vorratsmilben in kommerziellem Hundetrockenfutter und in der Umgebung sowie ihre Bedeutung in der Tiermedizin","volume":"35","author":"K Henneveld","year":"2007","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1365-3164.2008.00654.x","article-title":"Assessment of cross-reactivity among five species of house dust and storage mites","volume":"19","author":"M N Saridomichelakis","year":"2008","journal-title":"Vet Dermatol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/cea.12583","article-title":"The Danish urban-rural gradient of allergic sensitization and disease in adults","volume":"46","author":"G Elholm","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/j.1365-3164.2004.00400.x","article-title":"Determination of threshold concentrations of allergens and evaluation of two different histamine concentrations in canine intradermal testing","volume":"15","author":"P Hensel","year":"2004","journal-title":"Vet Dermatol"},{"key":"ref21","first-page":"5","article-title":"Intradermale Reaktionen gegen die Vorratsmilbe Lepidoglyphus destructor bei normalen Hunden und Hunden mit atopischer Dermatitis","volume":"56","author":"R S Mueller","year":"2011","journal-title":"Kleintierprax"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/vde.12742","article-title":"Agreement of serum allergen test results with unblocked and blocked IgE against cross-reactive carbohydrate determinants (CCD) and intradermal test results in atopic dogs","volume":"30","author":"NK Y Gedon","year":"2019","journal-title":"Vet Dermatol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1590\/abd1806-4841.20163927","article-title":"Patch-test results in children and adolescents: systematic review of a 15-year period","volume":"91","author":"D F Rodrigues","year":"2016","journal-title":"An Bras Dermatol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/j.1365-3164.2005.00472.x","article-title":"Atopy patch test reactions in high-IgE beagles to different sources and concentrations of house dust mites","volume":"16","author":"R Marsella","year":"2005","journal-title":"Vet Dermatol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1365-3164.2006.00502.x","article-title":"Patch testing of experimentally sensitized beagle dogs: development of a model for skin lesions of atopic dermatitis","volume":"17","author":"T Olivry","year":"2006","journal-title":"Vet Dermatol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/j.1365-3164.2009.00797.x","article-title":"Determination of irritant threshold concentrations to weeds, trees and grasses through serial dilutions in intradermal testing on healthy clinically nonallergic dogs","volume":"21","author":"C L Bauer","year":"2010","journal-title":"Vet Dermatol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/j.1365-3164.2008.00669.x","article-title":"A prospective study on canine atopic dermatitis and food-induced allergic dermatitis in Switzerland","volume":"19","author":"F Picco","year":"2008","journal-title":"Vet Dermatol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12917-016-0917-z","article-title":"Effectiveness of regionally-specific immunotherapy for the management of canine atopic dermatitis","volume":"13","author":"J D Plant","year":"2017","journal-title":"BMC Vet Res"},{"issue":"05","key":"ref29","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1136\/vr.104230","article-title":"Preliminary evaluation of cytosine-phosphate-guanine oligodeoxynucleotides bound to gelatine nanoparticles as immunotherapy for canine atopic dermatitis","volume":"181","author":"I Wagner","year":"2017","journal-title":"Vet Rec"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s12917-017-1142-0","article-title":"Critically appraised topic on adverse food reactions of companion animals (4): can we diagnose adverse food reactions in dogs and cats with in vivo or in vitro tests?","volume":"13","author":"R S Mueller","year":"2017","journal-title":"BMC Vet Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1365-3164.2002.00298_10.x","article-title":"Serological responses to house dust mite antigens in atopic dogs while receiving allergen-specific immunotherapy","volume":"13","author":"A P Foster","year":"2002","journal-title":"Vet Dermatol"}],"container-title":["Tier\u00e4rztliche Praxis Ausgabe K: Kleintiere \/ Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1584-4965.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T22:34:21Z","timestamp":1634769261000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1584-4965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":31,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2021,10,20]]},"published-print":{"date-parts":[[2021,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1584-4965","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"value":"1434-1239","type":"print"},{"value":"2567-5842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}