{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T22:40:40Z","timestamp":1774737640520,"version":"3.50.1"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three new flavanols, (2R,3S)-7-methoxy-flavan-3-ol (1),\n\t\t\t\t\t\t(2R,3S)-7-hydroxy-flavan-3-ol (2), and\n\t\t\t\t\t\t(2R,3S)-2\u2032-hydroxy-7-methoxy-flavan-3-ol (3), together\n\t\t\t\t\twith two known flavans (4 and 5), were isolated from the\n\t\t\t\t\tchloroform extract of Crinum asiaticum. Their structures were elucidated\n\t\t\t\t\tby various spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and CD\n\t\t\t\t\tdata. The isolated compounds 1 and 3\u22125 showed inhibitory\n\t\t\t\t\tactivity toward LPS-induced nitric oxide (NO) production. Further investigation\n\t\t\t\t\tof the NF-\u03baB pathway mechanisms indicated that 1 and\n\t\t\t\t\t\t3\u22125 inhibited the LPS-induced IL-6 production and p65 subunit\n\t\t\t\t\tphosphorylation of NF-\u03baB in RAW264.7 cells, with an effective dose of\n\t\t\t\t\t10\u2009\u00b5M.<\/jats:p>","DOI":"10.1055\/a-1585-5877","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T22:49:42Z","timestamp":1630622982000},"page":"913-920","source":"Crossref","is-referenced-by-count":6,"title":["Flavanols and Flavanes from Crinum asiaticum and Their Effects\n\t\t\t\t\ton LPS Signaling Pathway Through the Inhibition of NF-\u03baB\n\t\t\t\t\tActivation"],"prefix":"10.1055","volume":"88","author":[{"given":"Kiep Minh","family":"Do","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine, University of Toyama, Toyama,\n\t\t\t\t\tJapan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Kyoung","family":"Shin","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine, University of Toyama, Toyama,\n\t\t\t\t\tJapan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kodama","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine, University of Toyama, Toyama,\n\t\t\t\t\tJapan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nwet Nwet","family":"Win","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine, University of Toyama, Toyama,\n\t\t\t\t\tJapan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prema","family":"Prema","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine, University of Toyama, Toyama,\n\t\t\t\t\tJapan"},{"name":"Department of Chemistry, University of Yangon, Yangon,\n\t\t\t\t\tMyanmar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hien Minh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City,\n\t\t\t\t\tVietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine, University of Toyama, Toyama,\n\t\t\t\t\tJapan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Morita","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine, University of Toyama, Toyama,\n\t\t\t\t\tJapan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"ref1","first-page":"264","article-title":"Amaryllidaceae","volume":"24","author":"J Zhanhe","year":"2000","journal-title":"Flora of China"},{"key":"ref2","first-page":"190","article-title":"Crinum latifolium L. var. crilae Tram & Khanh, var. n-\n\t\t\t\t\tA new variety of the species Crinum latifolium L. 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