{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:30:41Z","timestamp":1758702641493},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"12","funder":[{"name":"Advent Health for Children"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to determine the association between daily fluid intake and the duration of hemodynamically significant patent ductus arteriosus (hsPDA).<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective cohort study of extremely preterm infants (&lt;29 weeks) admitted in the Neonatal Intensive Care Unit of the Advent Health for Children from January 2013 to March 2016, if hsPDA was diagnosed in first week of life and serial echocardiograms were available. Diagnosis of hsPDA was based on a scoring system and its duration was estimated from serial echocardiograms. Cohort was divided into two groups based on duration of hsPDA (&lt;1week, group A and \u22651 week, group B). Daily fluid intake was categorized as prescribed and actual. Prescribed volume was ordered by clinicians based on birth weight, not including trophic feeds, intravenous (IV) boluses or transfusions, etc. Actual intake was calculated by the electronic medical records based on daily weights and included all enteral or parenteral fluids. Multivariate analysis was performed to determine an association between total daily fluid intake over the first week of life and the duration of hsPDA. Two groups were compared to observe the difference between prescribed and actual daily fluid intakes.<\/jats:p><jats:p>\n            Results\u2003We enrolled 50 infants in group A and 76 in group B. Infants in group B were of significantly lower gestation and required prolonged ventilation and hospitalization. An association between higher fluid intake in the first 2 days of life and prolonged duration of hsPDA was confirmed by multivariate analysis. Actual fluid intake was significantly higher than prescribed total fluid intake in first 4 days of life for infants in both groups.<\/jats:p><jats:p>\n            Conclusion\u2003In extremely preterm infants, higher fluid intake in first 2 days of life is associated with prolonged duration of hsPDA. Actual daily fluid intake can be significantly higher than prescribed daily fluids due to daily weight changes and additional fluid administration.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1585-6093","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T23:12:12Z","timestamp":1628809932000},"page":"1345-1350","source":"Crossref","is-referenced-by-count":5,"title":["Fluid Intake in the First Week of Life and the Duration of Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants"],"prefix":"10.1055","volume":"40","author":[{"given":"Hussnain","family":"Mirza","sequence":"additional","affiliation":[{"name":"Center for Neonatal Care, University Central Florida College of Medicine, Advent Health for Children, Orlando, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Garcia","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Advent Health for Children, Orlando, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea","family":"Bell","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Program, Advent Health for Children, Orlando, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Jones","sequence":"additional","affiliation":[{"name":"Pediatric Pharmacy Services, Advent Health for Children, Orlando, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicki","family":"Flynn","sequence":"additional","affiliation":[{"name":"Office of Pediatric Research Advancement and Support, Advent Health, Orlando, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Pepe","sequence":"additional","affiliation":[{"name":"Office of Pediatric Research Advancement and Support, Advent Health, Orlando, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Oh","sequence":"additional","affiliation":[{"name":"Office of Pediatric Research Advancement and Support, Advent Health, Orlando, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"F55","DOI":"10.1136\/archdischild-2014-306339","article-title":"Natural evolution of patent ductus arteriosus in the extremely preterm infant","volume":"100","author":"A Rolland","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"F431","DOI":"10.1136\/archdischild-2014-306176","article-title":"Managing the patent ductus arteriosus: current treatment options","volume":"99","author":"A M Heuchan","year":"2014","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"S 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