{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T22:37:30Z","timestamp":1785019050737,"version":"3.55.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was to evaluate the expression of miR-129\u20135p in non-alcoholic\nfatty liver (NAFLD) patients and its clinical value and explore its regulatory\neffect on insulin resistance (IR). A total of 117 NAFLD patients and 110 healthy\ncontrols were included. The levels of miR-129-5p were detected by qRT-PCR. To\nassess the diagnostic value of miR-129-5p for NAFLD, the receiver operating\ncharacteristic curve (ROC) was established. C57Bl\/6 mice were supplied\nwith high-fat diet to establish NAFLD model. Intraperitoneal insulin tolerance\ntest (IPITT) was carried out to evaluate the effect of miR-129-5p on IR in NAFLD\nanimal model. miR-129-5p was highly expressed in the serum of NAFLD patients,\nand patients with HOMA-IR \u22652.5 had higher level of miR-129-5p than those\nwith HOMA-IR &lt;2.5. miR-129-5p had the ability to differentiate NAFLD\npatients from healthy individuals and might be associated with the development\nof IR. Serum miR-129-5p was positively correlated with the levels of HOMA-IR,\nBMI, total cholesterol (TC), and triglyceride (TG) in NAFLD patients.\nDownregulation of miR-129-5p regulates lipid metabolism and insulin sensitivity\nin NAFLD mice model. MiR-129-5p was upregulated in NAFLD patients and might be a\npotential diagnostic biomarker. The regulatory effect of miR-129-5p on NAFLD may\nfunction by regulating lipid accumulation and insulin sensitivity.<\/jats:p>","DOI":"10.1055\/a-1587-9211","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:05:04Z","timestamp":1631750704000},"page":"692-698","source":"Crossref","is-referenced-by-count":9,"title":["Clinical Value and Role of miR-129-5p in Non-Alcoholic Fatty Liver\nDisease"],"prefix":"10.1055","volume":"53","author":[{"given":"Yuan","family":"Wang","sequence":"first","affiliation":[{"name":"Sub-Health Clinic of Physical Examination Center, Beijing Fengtai\nHospital of Integrated Traditional Chinese and Western Medicine, Beijing,\nChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, People's Hospital of Rizhao,\nRizhao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shanghai Tenth\nPeople's Hospital,Tongji University School of Medicine, Shanghai,\nChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Liver Center, The Affiliated Hospital of Qingdao\nUniversity, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7059-5343","authenticated-orcid":false,"given":"Qinghui","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Liver Center, The Affiliated Hospital of Qingdao\nUniversity, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Affiliated Hospital of Qingdao\nUniversity, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The Affiliated Hospital of Qingdao\nUniversity, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"7352","DOI":"10.3390\/ijms15057352","article-title":"Molecular mechanisms and new treatment strategies for non-alcoholic\nsteatohepatitis (NASH)","volume":"15","author":"A Takaki","year":"2014","journal-title":"Int J Mol Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment\nof prevalence, incidence, and outcomes","volume":"64","author":"Z M 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