{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T18:00:24Z","timestamp":1785261624147,"version":"3.55.0"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorder\nin women of reproductive age. Vitamin D and its receptor are thought to play an\nimportant role in PCOS susceptibility, although the impact of vitamin D receptor\n(VDR) polymorphisms on the hormonal and metabolic profile is still\ncontroversial. A literature search in PubMed and Embase was performed up to\nSeptember 2020 for case-control studies in women suffering from PCOS, with\noutcome related to VDR polymorphisms effect on metabolic\/endocrine\ndisturbances. We have found 16 eligible studies including 2566 women with PCOS\nand 2430 controls. ApaI polymorphism seemed to be associated with\nhyperandrogenism in both Asian and Caucasian population. FokI variant was\ncorrelated with metabolic\/endocrine parameters especially in Asian\npopulation, while a relation between Cdx2 genotypes and insulin sensitivity was\nobserved in both ethnicities. VDR polymorphisms have an important role in PCOS\ndevelopment and related hormonal and metabolic abnormalities. Few case-control\nstudies analysed the interaction between VDR variants and\nmetabolic\/endocrine parameters with the majority of the articles focused\non the Asian region. Further research on various ethnic populations with larger\nsample size are still needed for a definitive conclusion, in order to allow\nearly diagnosis and prevention of PCOS comorbidities. <\/jats:p>","DOI":"10.1055\/a-1587-9336","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T23:14:50Z","timestamp":1632179690000},"page":"645-653","source":"Crossref","is-referenced-by-count":14,"title":["Polymorphisms of Vitamin D Receptor and the Effect on Metabolic and\nEndocrine Abnormalities in Polycystic Ovary Syndrome: A Review"],"prefix":"10.1055","volume":"53","author":[{"given":"Talida","family":"Vulcan","sequence":"additional","affiliation":[{"name":"Iuliu Hatieganu University of Medicine and Pharmacy Faculty of\nMedicine, Dermatology Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7447-4925","authenticated-orcid":false,"given":"Gabriela Adriana","family":"Filip","sequence":"additional","affiliation":[{"name":"Iuliu Hatieganu University of Medicine and Pharmacy Faculty of\nMedicine, Physiology Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia Manuela","family":"Lenghel","sequence":"additional","affiliation":[{"name":"Iuliu Hatieganu University of Medicine and Pharmacy Faculty of\nMedicine, Radiology, Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor","family":"Suciu","sequence":"additional","affiliation":[{"name":"Iuliu Hatieganu University of Medicine and Pharmacy Faculty of\nMedicine, Maxillofacial Surgery and Radiology, Cluj Napoca,\nRomania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Ilut","sequence":"additional","affiliation":[{"name":"Iuliu Hatieganu University of Medicine and Pharmacy Faculty of\nMedicine, Dermatology Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Maria","family":"Procopciuc","sequence":"additional","affiliation":[{"name":"Iuliu Hatieganu University of Medicine and Pharmacy Faculty of\nMedicine, Medical Biochemistry, Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"R Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.05.003","article-title":"Criteria, prevalence, and phenotypes of polycystic ovary syndrome","volume":"106","author":"D Lizneva","year":"2016","journal-title":"Fertil Steril"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/jog.13250","article-title":"Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic\nreview","volume":"43","author":"GVO P Reis","year":"2017","journal-title":"J Obstet Gynaecol Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1093\/humrep\/dew218","article-title":"The prevalence and phenotypic features of polycystic ovary syndrome: A\nsystematic review and meta-analysis","volume":"31","author":"G Bozdag","year":"2016","journal-title":"Hum Reprod"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1590\/1806-9282.62.09.867","article-title":"Current aspects of polycystic ovary syndrome: a literature review","volume":"62","author":"V H Andrade","year":"2016","journal-title":"Rev Assoc Med Bras"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.17219\/acem\/59380","article-title":"The pathogenesis and 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Thomali","year":"2018","journal-title":"J Med Biochem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.gene.2012.11.049","article-title":"Genetic polymorphism of vitamin D receptor gene affects the phenotype of\nPCOS","volume":"515","author":"A Zadeh-Vakili","year":"2013","journal-title":"Gene"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/09513590.2018.1512966","article-title":"Polymorphisms in vitamin D receptor gene, but not vitamin D levels, are\nassociated with polycystic ovary syndrome in Brazilian women","volume":"35","author":"L B Xavier","year":"2019","journal-title":"Gynecol Endocrinol"},{"key":"ref24","first-page":"4162","article-title":"Vitamin D receptor polymorphisms and melanoma","volume":"17","author":"A F Vasilovici","year":"2019","journal-title":"Oncol Lett"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.gene.2004.05.014","article-title":"Genetics and biology of 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syndrome","volume":"9","author":"E H Humadi","year":"2018","journal-title":"Indian J Public Health Res Dev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3109\/09513590.2015.1062865","article-title":"Classic PCOS phenotype is not associated with deficiency of endogenous vitamin D\nand VDR gene polymorphisms rs731236 (TaqI), rs7975232 (ApaI), rs1544410 (BsmI),\nrs10735810 (FokI): a case-control study of lower Silesian women","volume":"31","author":"D Jedrzejuk","year":"2015","journal-title":"Gynecol Endocrinol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s10815-019-01472-3","article-title":"Anti-M\u00fcllerian hormone level is associated with vitamin D receptor\npolymorphisms in women with polycystic ovary syndrome","volume":"36","author":"M Szafarowska","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"ref31","first-page":"247","article-title":"Genetic polymorphism in the vitamin D receptor gene and 25-hydroxyvitamin D\nserum levels in East Indian women with polycystic ovary syndrome","volume":"6","author":"S Dipanshu","year":"2015","journal-title":"J Mol Biomark Diagn"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12958-018-0355-9","article-title":"Apa-I polymorphism in VDR gene is related to metabolic syndrome in polycystic\novary syndrome: A cross-sectional study","volume":"16","author":"B R Santos","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"ref33","first-page":"104","article-title":"Correlation between vitamin D receptor gene polymorphisms and levels of some\nhormones in Iraqi infertile women with polycystic ovary syndrome","volume":"16","author":"S J Kadhim","year":"2017","journal-title":"Iraqi J Biotechnol"},{"key":"ref35","first-page":"303","article-title":"Lack of association of vitamin D receptor FokI (rs10735810) (C\/T) and\nBsmI (rs1544410) (A\/G) genetic variations with polycystic ovary syndrome\nrisk: a case-control study from Iranian Azeri Turkish women","volume":"7","author":"M Bagheri","year":"2012","journal-title":"Maedica (Bucur)"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10815-010-9506-4","article-title":"Influence of gene variants related to calcium homeostasis on biochemical\nparameters of women with polycystic ovary syndrome","volume":"28","author":"F Ranjzad","year":"2011","journal-title":"J Assist Reprod Genet"},{"key":"ref37","first-page":"877","article-title":"Association of BsmI variant of vitamin D receptor gene with polycystic ovary\nsyndrome: A case-control study","volume":"18","author":"N Ramezani","year":"2020","journal-title":"Int J Reprod BioMed"},{"key":"ref38","first-page":"116","article-title":"Vitamin D receptor TaqI gene variant in exon 9 and polycystic ovary syndrome\nrisk","volume":"7","author":"M Bagheri","year":"2013","journal-title":"Int J Fertil Steril"},{"key":"ref39","first-page":"27","article-title":"Assessment of vitamin D receptor gene polymorphism in Iraqi women with\npolycystic ovary syndrome","volume":"12","author":"R A Hamdi","year":"2018","journal-title":"J Clin Diagnostic Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.abb.2012.04.001","article-title":"Where is the vitamin D receptor?","volume":"523","author":"Y Wang","year":"2012","journal-title":"Arch Biochem Biophys"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3390\/nu11040794","article-title":"Analysis of association between vitamin D deficiency and insulin resistance","volume":"11","author":"I Szymczak-Pajor","year":"2019","journal-title":"Nutrients"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1055\/s-2006-948308","article-title":"Low serum 25-hydroxyvitamin D concentrations are associated with insulin\nresistance and obesity in women with polycystic ovary syndrome","volume":"114","author":"S Hahn","year":"2006","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.clnu.2020.09.024","article-title":"Androgens and hirsutism score of overweight women with polycystic ovary syndrome\nimproved after vitamin D treatment: A randomized placebo controlled clinical\ntrial","volume":"40","author":"N Al-Bayyari","year":"2021","journal-title":"Clin Nutr"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1587-9336.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:54:32Z","timestamp":1633395272000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1587-9336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,20]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10,4]]},"published-print":{"date-parts":[[2021,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1587-9336","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,20]]}}}