{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:00:22Z","timestamp":1764050422627,"version":"3.45.0"},"reference-count":72,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1055\/a-1589-7520","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T18:38:34Z","timestamp":1642531114000},"page":"81-107","source":"Crossref","is-referenced-by-count":0,"title":["S3-Leitlinie: Diagnostik und Therapie des hepatozellul\u00e4ren Karzinoms \u2013 Kurzversion 2.00 \u2013 Juni 2021, AWMF-Registernummer: 032-053OL"],"prefix":"10.1055","volume":"60","author":[{"given":"Voesch","family":"Sabrina","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Universit\u00e4tsklinikum T\u00fcbingen, T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bitzer","family":"Michael","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Universit\u00e4tsklinikum T\u00fcbingen, T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"J\u00f6rg","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Gastroenterologie, Hepatologie und Endokrinologie, Stuttgart"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartenstein","family":"Peter","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Nuklearmedizin, LMU Klinikum, M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bechstein","family":"Wolf","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral-, Transplantations- und Thoraxchirurgie, Universit\u00e4tsklinikum Frankfurt, Frankfurt am Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bl\u00f6dt","family":"Susanne","sequence":"additional","affiliation":[{"name":"AWMF-Gesch\u00e4ftsstelle, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brunner","family":"Thomas","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Strahlentherapie, Universit\u00e4tsklinikum Magdeburg A. \u00f6. R., Magdeburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dombrowski","family":"Frank","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Universit\u00e4tsmedizin Greifswald, Greifswald"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evert","family":"Matthias","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Regensburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Follmann","family":"Markus","sequence":"additional","affiliation":[{"name":"Office des Leitlinienprogrammes Onkologie, c\/o Deutsche Krebsgesellschaft e.V. Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"La Foug\u00e8re","family":"Christian","sequence":"additional","affiliation":[{"name":"Nuklearmedizin und Klinische Molekulare Bildgebung, T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freudenberger","family":"Paul","sequence":"additional","affiliation":[{"name":"Clinical Guideline Services GmbH, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geier","family":"Andreas","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg, W\u00fcrzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gkika","family":"Eleni","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Strahlenheilkunde, Department f\u00fcr Radiologische Diagnostik und Therapie, Universit\u00e4tsklinikum Freiburg, Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6tz","family":"Martin","sequence":"additional","affiliation":[{"name":"Kliniken B\u00f6blingen, B\u00f6blingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hammes","family":"Elke","sequence":"additional","affiliation":[{"name":"Lebertransplantierte Deutschland e. V., Ansbach"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmberger","family":"Thomas","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Radiologie, Neuroradiologie und minimal-invasive Therapie, M\u00fcnchen Klinik Bogenhausen, M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoffmann","family":"Ralf-Thorsten","sequence":"additional","affiliation":[{"name":"Institut und Poliklinik f\u00fcr Diagnostische und Interventionelle Radiologie, Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hofmann","family":"Wolf-Peter","sequence":"additional","affiliation":[{"name":"Gastroenterologie am Bayerischen Platz, medizinisches Versorgungszentrum, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huppert","family":"Peter","sequence":"additional","affiliation":[{"name":"Radiologisches Zentrum, Max Grundig Klinik, B\u00fchl"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kautz","family":"Achim","sequence":"additional","affiliation":[{"name":"Deutsche Leberhilfe e.V., K\u00f6ln"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kn\u00f6tgen","family":"Gabi","sequence":"additional","affiliation":[{"name":"Konferenz onkologischer Kranken- und Kinderkrankenpflege, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00f6rber","family":"J\u00fcrgen","sequence":"additional","affiliation":[{"name":"Klinik Nahetal, Fachklinik f\u00fcr onkologische Rehabilitation und Anschlussrehabilitation, (AHB), Bad Kreuznach"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krug","family":"David","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Strahlentherapie, Universit\u00e4tsklinikum Schleswig-Holstein, Kiel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lammert","family":"Frank","sequence":"additional","affiliation":[{"name":"Medizinische Hochschule Hannover, Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"Hauke","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral und Transplantationschirurgie, Universit\u00e4tsmedizin der Johannes Gutenberg-Universit\u00e4t Mainz, Mainz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Langer","family":"Thomas","sequence":"additional","affiliation":[{"name":"Office des Leitlinienprogrammes Onkologie, c\/o Deutsche Krebsgesellschaft e.V. Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenz","family":"Philipp","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum M\u00fcnster, Zentrale Einrichtung Palliativmedizin, M\u00fcnster"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnken","family":"Andreas","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Diagnostische und Interventionelle Radiologie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg GmbH, Marburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meining","family":"Alexander","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik II des Universit\u00e4tsklinikums W\u00fcrzburg, W\u00fcrzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micke","family":"Oliver","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Strahlentherapie und Radioonkologie, Franziskus Hospital Bielefeld, Bielefeld"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadalin","family":"Silvio","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, Universit\u00e4tsklinikum T\u00fcbingen, T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Huu Phuc","sequence":"additional","affiliation":[{"name":"Humangenetik, Ruhr-Universit\u00e4t, Bochum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ockenga","family":"Johann","sequence":"additional","affiliation":[{"name":"Medizinische Klinik II, Klinikum Bremen-Mitte, Bremen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oldhafer","family":"Karl-J\u00fcrgen","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Leber-, Gallenwegs- und Pankreaschirurgie, Semmelweis Universit\u00e4t, Asklepios Campus Hamburg, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paprottka","family":"Philipp","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr interventionelle Radiologie, Klinikum rechts der Isar der Technischen Universit\u00e4t M\u00fcnchen, M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paradies","family":"Kerstin","sequence":"additional","affiliation":[{"name":"Konferenz onkologischer Kranken- und Kinderkrankenpflege, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pereira","family":"Philippe","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Radiologie, Minimal-invasive Therapien und Nuklearmedizin, Klinikum am Gesundbrunnen, SLK-Kliniken Heilbronn GmbH, Heilbronn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Persigehl","family":"Thorsten","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Diagnostische und Interventionelle Radiologie, Universit\u00e4tsklinikum K\u00f6ln, K\u00f6ln"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Plauth","family":"Mathias","sequence":"additional","affiliation":[{"name":"St\u00e4dtisches Klinikum Dessau, Dessau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Plentz","family":"Ruben","sequence":"additional","affiliation":[{"name":"Klinikum Bremen-Nord, Innere Medizin, Bremen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pohl","family":"J\u00fcrgen","sequence":"additional","affiliation":[{"name":"Interventionelles Endoskopiezentrum und Schwerpunkt Gastrointestinale Onkologie, Asklepios Klinik Altona, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riemer","family":"Jutta","sequence":"additional","affiliation":[{"name":"Lebertransplantierte Deutschland e. V., Bretzfeld"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reimer","family":"Peter","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr diagnostische und interventionelle Radiologie, St\u00e4dtisches Klinikum Karlsruhe gGmbH, Karlsruhe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ringwald","family":"Johanna","sequence":"additional","affiliation":[{"name":"Psychosomatische Medizin und Psychotherapie, Universit\u00e4tsklinikum T\u00fcbingen, T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritterbusch","family":"Ulrike","sequence":"additional","affiliation":[{"name":"Hospizarbeit am Universit\u00e4tsklinikum Essen, Essen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roeb","family":"Elke","sequence":"additional","affiliation":[{"name":"Medizinische Klinik II, Universit\u00e4tsklinikum Gie\u00dfen und Marburg GmbH, Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schellhaas","family":"Barbara","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Friedrich-Alexander Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schirmacher","family":"Peter","sequence":"additional","affiliation":[{"name":"Pathologisches Institut, Universit\u00e4tsklinikum Heidelberg, Heidelberg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schmid","family":"Irene","sequence":"additional","affiliation":[{"name":"Zentrum P\u00e4diatrische H\u00e4matologie und Onkologie, Dr. von Haunersches Kinderspital, Klinikum der Universit\u00e4t M\u00fcnchen, M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schuler","family":"Andreas","sequence":"additional","affiliation":[{"name":"Medizinische Klinik, Alb Fils Kliniken GmbH, G\u00f6ppingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"von Schweinitz","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Dietrich (SRH Wilhelm L\u00f6he Hochschule, F\u00fcrth"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seehofer","family":"Daniel","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Viszeral-, Transplantations-, Thorax- und Gef\u00e4\u00dfchirurgie, Universit\u00e4tsklinikum Leipzig, Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinn","family":"Marianne","sequence":"additional","affiliation":[{"name":"Medizinische Klinik II, Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stein","family":"Alexander","sequence":"additional","affiliation":[{"name":"H\u00e4matologisch-Onkologischen Praxis Eppendorf, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stengel","family":"Andreas","sequence":"additional","affiliation":[{"name":"Psychosomatische Medizin und Psychotherapie, Universit\u00e4tsklinikum T\u00fcbingen, T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steubesand","family":"Nadine","sequence":"additional","affiliation":[{"name":"Clinical Guideline Services GmbH, Kiel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stoll","family":"Christian","sequence":"additional","affiliation":[{"name":"Klinik Herzogh\u00f6he Bayreuth, Bayreuth"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tannapfel","family":"Andrea","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie der Ruhr-Universit\u00e4t Bochum am Berufsgenossenschaftlichen Universit\u00e4tsklinikum Bergmannsheil, Bochum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taubert","family":"Anne","sequence":"additional","affiliation":[{"name":"Kliniksozialdienst, Universit\u00e4tsklinikum Heidelberg, Bochum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trojan","family":"J\u00f6rg","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Universit\u00e4tsklinikum Frankfurt, Frankfurt am Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"van Thiel","family":"Ingo","sequence":"additional","affiliation":[{"name":"Deutsche Leberhilfe e.V., K\u00f6ln"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tholen","family":"Reina","sequence":"additional","affiliation":[{"name":"Deutscher Verband f\u00fcr Physiotherapie e. V., K\u00f6ln"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vogel","family":"Arndt","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie, Hepatologie, Endokrinologie der Medizinischen Hochschule Hannover, Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vogl","family":"Thomas","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Frankfurt, Institut f\u00fcr Diagnostische und Interventionelle Radiologie, Frankfurt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vorwerk","family":"Hilke","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Strahlentherapie, Universit\u00e4tsklinikum Gie\u00dfen und Marburg GmbH, Marburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wacker","family":"Frank","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Diagnostische und Interventionelle Radiologie der Medizinischen Hochschule Hannover, Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waidmann","family":"Oliver","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Universit\u00e4tsklinikum Frankfurt, Frankfurt am Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wedemeyer","family":"Heiner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie, Hepatologie und Endokrinologie Medizinische Hochschule Hannover, Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wege","family":"Henning","sequence":"additional","affiliation":[{"name":"I. Medizinische Klinik und Poliklinik, Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wildner","family":"Dane","sequence":"additional","affiliation":[{"name":"Innere Medizin, Krankenh\u00e4user N\u00fcrnberger Land GmbH, Lauf an der Pegnitz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wittekind","family":"Christian","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum Leipzig, Leipzig"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W\u00f6rns","family":"Marcus-Alexander","sequence":"additional","affiliation":[{"name":"I. Medizinische Klinik und Poliklinik, Universit\u00e4tsklinikum Mainz, Mainz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galle","family":"Peter","sequence":"additional","affiliation":[{"name":"I. Medizinische Klinik und Poliklinik, Universit\u00e4tsklinikum Mainz, Mainz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malek","family":"Nisar","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Universit\u00e4tsklinikum T\u00fcbingen, T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"ref3","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/hep.24199","article-title":"Management of hepatocellular carcinoma: an update","volume":"53","author":"J Bruix","year":"2011","journal-title":"Hepatology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/jvh.12727","article-title":"Prediction of long-term clinical outcome in a diverse chronic hepatitis B population: Role of the PAGE-B score","volume":"24","author":"W P Brouwer","year":"2017","journal-title":"J Viral Hepat"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.jhep.2015.11.035","article-title":"PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy","volume":"64","author":"G Papatheodoridis","year":"2016","journal-title":"J Hepatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma","volume":"69","year":"2018","journal-title":"J Hepatol"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/jnci\/dji040","article-title":"Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: a prospective study in Japan","volume":"97","author":"M Inoue","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/CEJ.0000000000000252","article-title":"Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies","volume":"26","author":"F Bravi","year":"2017","journal-title":"Eur J Cancer Prev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.3945\/ajcn.115.116095","article-title":"The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition","volume":"102","author":"K Aleksandrova","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1053\/j.gastro.2014.10.005","article-title":"Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort","volume":"148","author":"V W Setiawan","year":"2015","journal-title":"Gastroenterology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00432-004-0552-0","article-title":"Randomized controlled trial of screening for hepatocellular carcinoma","volume":"130","author":"B H Zhang","year":"2004","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/apt.12370","article-title":"Surveillance for hepatocellular cancer with ultrasonography vs. computed tomography \u2013 a randomised study","volume":"38","author":"C Pocha","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/hep.24545","article-title":"Ultrasonographic surveillance of hepatocellular carcinoma in cirrhosis: a randomized trial comparing 3- and 6-month periodicities","volume":"54","author":"J C Trinchet","year":"2011","journal-title":"Hepatology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1053\/j.gastro.2018.01.064","article-title":"Surveillance Imaging and Alpha Fetoprotein for Early Detection of Hepatocellular Carcinoma in Patients With Cirrhosis: A Meta-analysis","volume":"154","author":"K Tzartzeva","year":"2018","journal-title":"Gastroenterology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1097\/MEG.0000000000001226","article-title":"Additional role of liver stiffness measurement in stratifying residual hepatocellular carcinoma risk predicted by serum biomarkers in chronic hepatitis B patients under antiviral therapy","volume":"30","author":"B G Song","year":"2018","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1053\/j.gastro.2019.07.033","article-title":"Increased Risk for Hepatocellular Carcinoma Persists Up to 10 Years After HCV Eradication in Patients With Baseline Cirrhosis or High FIB-4 Scores","volume":"157","author":"G N Ioannou","year":"2019","journal-title":"Gastroenterology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1002\/hep.1840380430","article-title":"MRI angiography is superior to helical CT for detection of HCC prior to liver transplantation: an explant correlation","volume":"38","author":"M Burrel","year":"2003","journal-title":"Hepatology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00330-012-2691-z","article-title":"Hepatocellular carcinoma in cirrhotic patients: prospective comparison of US, CT and MR imaging","volume":"23","author":"M Di Martino","year":"2013","journal-title":"Eur Radiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/jmri.22588","article-title":"Additional value of gadoxetic acid-DTPA-enhanced hepatobiliary phase MR imaging in the diagnosis of early-stage hepatocellular carcinoma: comparison with dynamic triple-phase multidetector CT imaging","volume":"34","author":"H Haradome","year":"2011","journal-title":"J Magn Reson Imaging"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jhep.2010.07.025","article-title":"Optimization of imaging diagnosis of 1\u20132 cm hepatocellular carcinoma: an analysis of diagnostic performance and resource utilization","volume":"54","author":"K Khalili","year":"2011","journal-title":"J Hepatol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1477-2574.2012.00617.x","article-title":"Evaluation of the seventh edition of the American Joint Committee on Cancer tumour-node-metastasis (TNM) staging system for patients undergoing curative resection of hepatocellular carcinoma: implications for the development of a refined staging system","volume":"15","author":"A C Chan","year":"2013","journal-title":"HPB (Oxford)"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0168-8278(99)80173-1","article-title":"A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. Groupe d\u02bcEtude et de Traitement du Carcinome Hepatocellulaire","volume":"31","author":"S Chevret","year":"1999","journal-title":"J Hepatol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1200\/JCO.2014.57.9151","article-title":"Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade","volume":"33","author":"P J Johnson","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"issue":"S 01","key":"ref24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000173428","article-title":"Validation of a new prognostic staging system for hepatocellular carcinoma: a comparison of the biomarker-combined Japan Integrated Staging Score, the conventional Japan Integrated Staging Score and the BALAD Score","volume":"75","author":"S Kitai","year":"2008","journal-title":"Oncology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1002\/cncr.10384","article-title":"Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system: a study based on 926 patients","volume":"94","author":"T W Leung","year":"2002","journal-title":"Cancer"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/hep.20636","article-title":"Prognosis of hepatocellular carcinoma: comparison of 7 staging systems in an American cohort","volume":"41","author":"J A Marrero","year":"2005","journal-title":"Hepatology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jhep.2016.09.008","article-title":"The ALBI grade provides objective hepatic reserve estimation across each BCLC stage of hepatocellular carcinoma","volume":"66","author":"D J Pinato","year":"2017","journal-title":"J Hepatol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.transproceed.2009.03.054","article-title":"Validation of the BCLC prognostic system in surgical hepatocellular cancer patients","volume":"41","author":"A Vitale","year":"2009","journal-title":"Transplant Proc"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1053\/j.gastro.2014.02.032","article-title":"Development of Hong Kong Liver Cancer staging system with treatment stratification for patients with hepatocellular carcinoma","volume":"146","author":"T Yau","year":"2014","journal-title":"Gastroenterology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/00365521.2016.1236396","article-title":"Impact of preoperative locoregional therapy on recurrence and patient survival following liver transplantation for hepatocellular carcinoma: a meta-analysis","volume":"52","author":"X Huang","year":"2017","journal-title":"Scand J Gastroenterol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/hep.29485","article-title":"Therapies for patients with hepatocellular carcinoma awaiting liver transplantation: A systematic review and meta-analysis","volume":"67","author":"L Kulik","year":"2018","journal-title":"Hepatology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/TP.0000000000001936","article-title":"Systematic Review and Meta-Analysis of Posttransplant Hepatic Artery and Biliary Complications in Patients Treated With Transarterial Chemoembolization Before Liver Transplantation","volume":"102","author":"D Sneiders","year":"2018","journal-title":"Transplantation"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.suronc.2019.10.006","article-title":"Extended criteria for liver transplantation in hepatocellular carcinoma. A retrospective, multicentric validation study in Belgium","volume":"33","author":"H Degroote","year":"2019","journal-title":"Surg Oncol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1002\/lt.24169","article-title":"Downstaging hepatocellular carcinoma: A systematic review and pooled analysis","volume":"21","author":"N D Parikh","year":"2015","journal-title":"Liver Transpl"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/S1470-2045(15)00198-9","article-title":"Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial","volume":"16","author":"J Bruix","year":"2015","journal-title":"Lancet Oncol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1053\/j.gastro.2015.02.055","article-title":"Adjuvant immunotherapy with autologous cytokine-induced killer cells for hepatocellular carcinoma","volume":"148","author":"J H Lee","year":"2015","journal-title":"Gastroenterology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/hep.21415","article-title":"Prevention of hepatocellular carcinoma recurrence with alpha-interferon after liver resection in HCV cirrhosis","volume":"44","author":"V Mazzaferro","year":"2006","journal-title":"Hepatology"},{"key":"ref38","first-page":"Cd001199","article-title":"Neoadjuvant and adjuvant therapy for surgical resection of hepatocellular carcinoma","volume":"1","author":"M Samuel","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0140-6736(00)02654-4","article-title":"Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial","volume":"356","author":"T Takayama","year":"2000","journal-title":"Lancet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/01.sla.0000201480.65519.b8","article-title":"A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma","volume":"243","author":"M S Chen","year":"2006","journal-title":"Ann Surg"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.jhep.2012.05.007","article-title":"A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma","volume":"57","author":"K Feng","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/SLA.0b013e3181efc656","article-title":"A randomized trial comparing radiofrequency ablation and surgical resection for HCC conforming to the Milan criteria","volume":"252","author":"J Huang","year":"2010","journal-title":"Ann Surg"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/bjs.10677","article-title":"Randomized clinical trial of hepatic resection versus radiofrequency ablation for early-stage hepatocellular carcinoma","volume":"104","author":"K KC Ng","year":"2017","journal-title":"Br J Surg"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jhep.2014.03.012","article-title":"Partial hepatectomy vs. transcatheter arterial chemoembolization for resectable multiple hepatocellular carcinoma beyond Milan Criteria: a RCT","volume":"61","author":"L Yin","year":"2014","journal-title":"J Hepatol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1055\/s-0030-1247132","article-title":"Modified RECIST (mRECIST) assessment for hepatocellular carcinoma","volume":"30","author":"R Lencioni","year":"2010","journal-title":"Semin Liver Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/jgh.12791","article-title":"Radiofrequency ablation versus laser ablation for the treatment of small hepatocellular carcinoma in cirrhosis: a randomized trial","volume":"30","author":"G G Di Costanzo","year":"2015","journal-title":"J Gastroenterol Hepatol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.dld.2013.10.015","article-title":"An explorative data-analysis to support the choice between hepatic resection and radiofrequency ablation in the treatment of hepatocellular carcinoma","volume":"46","author":"A Cucchetti","year":"2014","journal-title":"Dig Liver Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1200\/JCO.2012.42.9936","article-title":"Radiofrequency ablation with or without transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma: a prospective randomized trial","volume":"31","author":"Z W Peng","year":"2013","journal-title":"J Clin Oncol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/bjs.10061","article-title":"Randomized clinical trial of chemoembolization plus radiofrequency ablation versus partial hepatectomy for hepatocellular carcinoma within the Milan criteria","volume":"103","author":"H Liu","year":"2016","journal-title":"Br J Surg"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1080\/00365521.2018.1548645","article-title":"Efficacy of combination therapy with transcatheter arterial chemoembolization and radiofrequency ablation for intermediate-stage hepatocellular carcinoma","volume":"53","author":"K Endo","year":"2018","journal-title":"Scand J Gastroenterol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1053\/jhep.2002.33156","article-title":"Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma","volume":"35","author":"C M Lo","year":"2002","journal-title":"Hepatology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/S0140-6736(02)08649-X","article-title":"Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial","volume":"359","author":"J M Llovet","year":"2002","journal-title":"Lancet"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/bjc.2014.199","article-title":"Randomised controlled trial of doxorubicin-eluting beads vs conventional chemoembolisation for hepatocellular carcinoma","volume":"111","author":"R Golfieri","year":"2014","journal-title":"Br J Cancer"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00270-009-9711-7","article-title":"Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study","volume":"33","author":"J Lammer","year":"2010","journal-title":"Cardiovasc Intervent Radiol"},{"key":"ref55","first-page":"Cd011313","article-title":"Yttrium-90 microsphere radioembolisation for unresectable hepatocellular carcinoma","volume":"1","author":"O Abdel-Rahman","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"299","DOI":"10.20892\/j.issn.2095-3941.2017.0177","article-title":"Yttrium-90 transarterial radioembolization versus conventional transarterial chemoembolization for patients with hepatocellular carcinoma: a systematic review and meta-analysis","volume":"15","author":"Y Yang","year":"2018","journal-title":"Cancer Biol Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s00330-016-4548-3","article-title":"Meta-analysis: adjusted indirect comparison of drug-eluting bead transarterial chemoembolization versus (90)Y-radioembolization for hepatocellular carcinoma","volume":"27","author":"J M Ludwig","year":"2017","journal-title":"Eur Radiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.2147\/OTT.S175715","article-title":"Radioembolization versus chemoembolization for unresectable hepatocellular carcinoma: a meta-analysis of randomized trials","volume":"11","author":"A Casadei Gardini","year":"2018","journal-title":"Onco Targets Ther"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","article-title":"Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma","volume":"382","author":"R S Finn","year":"2020","journal-title":"N Engl J Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1470-2045(08)70285-7","article-title":"Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial","volume":"10","author":"A L Cheng","year":"2009","journal-title":"Lancet Oncol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1056\/NEJMoa0708857","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"J M Llovet","year":"2008","journal-title":"N Engl J Med"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0140-6736(18)30207-1","article-title":"Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial","volume":"391","author":"M Kudo","year":"2018","journal-title":"The Lancet"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0140-6736(16)32453-9","article-title":"Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"389","author":"J Bruix","year":"2017","journal-title":"Lancet"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMoa1717002","article-title":"Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma","volume":"379","author":"G K Abou-Alfa","year":"2018","journal-title":"N Engl J Med"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S1470-2045(18)30937-9","article-title":"Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased \u03b1-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"20","author":"A X Zhu","year":"2019","journal-title":"Lancet Oncol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.jhep.2016.07.020","article-title":"Observational registry of sorafenib use in clinical practice across Child-Pugh subgroups: The GIDEON study","volume":"65","author":"J A Marrero","year":"2016","journal-title":"J Hepatol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1158\/1078-0432.CCR-16-0919","article-title":"Sorafenib in Patients with Hepatocellular Carcinoma-Results of the Observational INSIGHT Study","volume":"23","author":"T M Ganten","year":"2017","journal-title":"Clin Cancer Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s10637-018-0621-x","article-title":"Survival and tolerance to sorafenib in Child-Pugh B patients with hepatocellular carcinoma: a prospective study","volume":"36","author":"C RG Leal","year":"2018","journal-title":"Invest New Drugs"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/annonc\/mds343","article-title":"Sorafenib in patients with Child-Pugh class A and B advanced hepatocellular carcinoma: a prospective feasibility analysis","volume":"24","author":"T Pressiani","year":"2013","journal-title":"Ann Oncol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10637-015-0237-3","article-title":"Sorafenib treatment in Child-Pugh A and B patients with advanced hepatocellular carcinoma: safety, efficacy and prognostic factors","volume":"33","author":"S Ogasawara","year":"2015","journal-title":"Invest New Drugs"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/S1470-2045(17)30683-6","article-title":"Efficacy and safety of selective internal radiotherapy with\u00a0yttrium-90 resin microspheres compared with sorafenib in locally advanced and inoperable hepatocellular carcinoma (SARAH): an open-label randomised controlled phase 3 trial","volume":"18","author":"V Vilgrain","year":"2017","journal-title":"Lancet Oncol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.jhep.2016.01.012","article-title":"Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: The SPACE trial","volume":"64","author":"R Lencioni","year":"2016","journal-title":"J Hepatol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S2468-1253(17)30156-5","article-title":"Sorafenib in combination with transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma (TACE 2): a randomised placebo-controlled, double-blind, phase 3 trial","volume":"2","author":"T Meyer","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1200\/JCO.2017.76.0892","article-title":"SIRveNIB: Selective Internal Radiation Therapy Versus Sorafenib in Asia-Pacific Patients With Hepatocellular Carcinoma","volume":"36","author":"P KH Chow","year":"2018","journal-title":"J Clin Oncol"}],"container-title":["Zeitschrift f\u00fcr Gastroenterologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1589-7520.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T05:35:34Z","timestamp":1764048934000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1589-7520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":72,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,1,18]]},"published-print":{"date-parts":[[2022,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1589-7520","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0044-2771","1439-7803"],"issn-type":[{"type":"print","value":"0044-2771"},{"type":"electronic","value":"1439-7803"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}