{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T20:29:42Z","timestamp":1709324982275},"reference-count":47,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Hintergrund\u2002Die chronische Rhinosinusitis mit Nasenpolypen (CRSwNP) ist eine multifaktorielle entz\u00fcndliche Erkrankung, oftmals auf der Grundlage einer Typ-2-Inflammation. F\u00fcr die Behandlung von Patienten mit einer schweren Auspr\u00e4gung ohne ausreichendes Ansprechen auf die Standardtherapie mit topischen nasalen Steroiden und\/oder Zustand nach endonasaler Operation sind als Biologika aktuell Dupilumab und Omalizumab f\u00fcr die Therapie zugelassen. Nachdem wir in einer fr\u00fcheren Publikation f\u00fcr Dupilumab bereits entsprechende Hinweise gegeben haben, ist das Ziel der vorliegenden Arbeit die Standardisierung von Patienteninformation und -aufkl\u00e4rung vor einer Therapie mit Omalizumab.<\/jats:p><jats:p>Methoden\u2002Auf Grundlage des aktuellen Wissensstandes zur Immunologie der CRSwNP und zu den erw\u00fcnschten und m\u00f6glichen unerw\u00fcnschten Wirkungen von Omalizumab werden Empfehlungen f\u00fcr die Patienteninformation entwickelt.<\/jats:p><jats:p>Ergebnisse\u2002Basierend auf der internationalen Literatur, der aktuellen Fachinformation und Erfahrungen aus der praktischen Anwendung und den derzeitigen Pharmakovigilanz-Daten hat ein Expertengremium Empfehlungen f\u00fcr die Patienteninformation und -aufkl\u00e4rung zur Anwendung von Omalizumab bei CRSwNP entwickelt und auf dieser Grundlage einen Patienteninformations- und Aufkl\u00e4rungsbogen erstellt.<\/jats:p><jats:p>Schlussfolgerung\u2002Die Information und Einwilligung des Patienten wird vor der Verordnung bzw. Verabreichung von allen Biologika, damit auch Omalizumab, empfohlen. Das vorliegende Positionspapier enth\u00e4lt wichtige Informationen zur praktischen Umsetzung und einen Vorschlag f\u00fcr eine Patienteninformation.<\/jats:p>","DOI":"10.1055\/a-1592-0316","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T22:41:12Z","timestamp":1631659272000},"page":"864-872","source":"Crossref","is-referenced-by-count":6,"title":["Positionspapier: Hinweise zur Patienteninformation und -aufkl\u00e4rung vor Anwendung von Biologika bei chronischer Rhinosinusitis mit\u00a0Nasenpolypen (CRSwNP) \u2013 Teil 2: Omalizumab \u2013 Empfehlungen des \u00c4rzteverbandes Deutscher Allergologen (AeDA) und der Deutschen\u00a0Gesellschaft f\u00fcr HNO-Heilkunde, Kopf- und Halschirurgie (DGHNOKHC)"],"prefix":"10.1055","volume":"100","author":[{"given":"U.","family":"F\u00f6rster-Ruhrmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Charit\u00e9-Universit\u00e4tsmedizin, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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