{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:45:34Z","timestamp":1788864334292,"version":"build-2803163510"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical characteristics of patients with postoperative hypoparathyroidism who recover parathyroid function more than 12 months after surgery have not been studied. We aimed to evaluate whether the intensity of replacement therapy with calcium and calcitriol is related to the late recovery of parathyroid function. We compared the demographic, surgical, pathological, and analytical features of two groups of patients: cases, i.\u2009e., late recovery patients (those who recover parathyroid function&gt;1 year after thyroidectomy, n=40), and controls, i.\u2009e., patients with permanent hypoparathyroidism (n=260). Replacement therapy with calcium and calcitriol was evaluated at discharge of surgery, 3\u20136 months, 12 months, and last visit. No significant differences were found in clinical, surgical, pathological, or analytical characteristics between cases and controls. The proportion of cases who required treatment with calcium plus calcitriol at 12 months was significantly lower than that found in controls (p&lt;0.001). Furthermore, daily calcium and calcitriol doses in controls were significantly higher than those in cases at 3\u20136 months (p=0.014 and p=0.004, respectively) and at 12 months (p&lt;0.001 and p=0.043, respectively). In several models of logistic regression analysis therapy with calcium and calcitriol at 12 months was negatively related to late recovery of parathyroid function. Although delayed recuperation of parathyroid function after total thyroidectomy is uncommon (13%), follow-up beyond 12 months is necessary in patients with postoperative hypoparathyroidism, especially in those whose needs of treatment with Ca and calcitriol are reducing over time.<\/jats:p>","DOI":"10.1055\/a-1608-1373","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T22:53:05Z","timestamp":1631573585000},"page":"654-661","source":"Crossref","is-referenced-by-count":5,"title":["Late Recovery of Parathyroid Function After Total Thyroidectomy: A Case-Control Study"],"prefix":"10.1055","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2017-0694","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"D\u00edez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain"},{"name":"Department of Endocrinology, Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro Segovia de Arana, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Anda","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Complejo Hospitalario de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Sastre","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Complejo Hospitalario de Toledo, Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a P\u00e9rez","family":"Corral","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Complejo Asistencial Universitario de Le\u00f3n, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"\u00c1lvarez-Escol\u00e1","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Manj\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Central de Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Paja","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario de Basurto, Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Sambo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piedad Santiago","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Complejo Hospitalario de Ja\u00e9n, Ja\u00e9n, Spain"},{"name":"Present address: Department of Endocrinology, Hospital Universitario Virgen de las Nieves, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n Blanco","family":"Carrera","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Pr\u00edncipe de Asturias, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Galofr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Cl\u00ednica Universidad de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Virgen del Roc\u00edo, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Zaf\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Vall d\u2019Hebron, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Vall d\u2019Hebron, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Oleaga","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario de Basurto, Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orosia","family":"Bandr\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Royo Villanova, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Donnay","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Fundaci\u00f3n Hospital de Alcorc\u00f3n, Alcorc\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Meg\u00eda","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Ciberdem, Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Picallo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia S\u00e1nchez","family":"Ragnarsson","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Central de Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Baena-Nieto","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital de Jerez, Jerez de la Frontera, C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Fern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Virgen de la Victoria, M\u00e1laga, Spain"},{"name":"Department of Endocrinology, Hospital Regional Universitario de M\u00e1laga, Institute of Biomedical Research in Malaga (IBIMA), Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Lecumberri","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel Sah\u00fan","family":"de la Vega","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Mois\u00e8s Broggi, Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana R.","family":"Romero-Lluch","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Virgen del Roc\u00edo, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain"},{"name":"Department of Endocrinology, Hospital Universitario Puerta de Hierro Majadahonda, Instituto de Investigaci\u00f3n Sanitaria Puerta de Hierro Segovia de Arana, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1055\/s-0043-106441","article-title":"Endocrine complications of surgical treatment of thyroid cancer: an update","volume":"125","author":"P Iglesias","year":"2017","journal-title":"Exp Clin Endocrinol 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