{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:24:09Z","timestamp":1777368249690,"version":"3.51.4"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n          Definition und Epidemiologie\u2002Die subklinische Hypothyreose ist in der Regel eine Labordiagnose ohne signifikante Symptomatik und definiert durch ein erh\u00f6htes TSH bei normalen Werten f\u00fcr freies T3 und freies T4. Bei Laborkontrollen nach 2\u20133 Monaten findet sich in 50\u200a% der F\u00e4lle eine spontane Normalisierung.<\/jats:p><jats:p>\n          Klinische Bedeutung der subklinischen Hypothyreose\u2002Bei persistierend erh\u00f6hten TSH-Werten ist die subklinische Hypothyreose mit dem Nachweis von schilddr\u00fcsenspezifischen Antik\u00f6rpern im Sinne einer Autoimmunthyreoiditis assoziiert. Im Alter finden sich physiologisch h\u00f6here TSH-Spiegel. Es ist deshalb davon auszugehen, dass die Diagnose einer subklinischen Hypothyreose bei \u00e4lteren Menschen \u00fcber 70 Jahre zu h\u00e4ufig gestellt und therapiert wird.<\/jats:p><jats:p>\n          Therapie der subklinischen Hypothyreose\u2002Studien konnten bisher keinen positiven Effekt einer Substitutionstherapie der subklinischen Hypothyreose zeigen, insbesondere nicht bei \u00e4lteren Patienten. Andererseits besteht das nicht unerhebliche Risiko einer \u00dcbertherapie mit der Entwicklung einer subklinischen Hyperthyreose. Deren negative Folgen in Form von Vorhofflimmern und Osteoporose beeintr\u00e4chtigen die Lebensqualit\u00e4t und -dauer. Bei der Indikationsstellung zur Substitutionstherapie einer subklinischen Hypothyreose sollte deshalb zur\u00fcckhaltend vorgegangen werden.<\/jats:p><jats:p>\n          Subklinische Hypothyreose in der Schwangerschaft\u2002Eine Gruppe, bei der Diagnostik und Therapie besondere Sensibilit\u00e4t erfordern, sind schwangere Frauen. Hier m\u00fcssen mit Mutter und Kind 2 Individuen behandelt werden. Dabei sind ver\u00e4nderliche Zielwerte und Dosierungen bezogen auf das Schwangerschaftsalter zu ber\u00fccksichtigen.<\/jats:p>","DOI":"10.1055\/a-1612-4816","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T23:42:17Z","timestamp":1647387737000},"page":"289-294","source":"Crossref","is-referenced-by-count":5,"title":["Subklinische Hypothyreose"],"prefix":"10.1055","volume":"147","author":[{"given":"Franz","family":"Ruderich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Feldkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1001\/archinte.160.4.526","article-title":"The Colorado thyroid disease prevalence study","volume":"160","author":"G J 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