{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:28:34Z","timestamp":1776450514564,"version":"3.51.2"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":108,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"linical Trial Centre of the Tata Memorial\n                        Centre for this study"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultrasound Int Open"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose A semantic feature-based reporting proforma for intraoperative\n                    ultrasound findings in brain tumors was devised to standardize reporting. It was\n                    applied as a pilot study on a cohort of histologically confirmed high-grade\n                    supratentorial gliomas (Grade 3 and 4) for internal validation.<\/jats:p><jats:p>\n          Materials and Methods This intraoperative semantic ultrasound proforma was\n                    used to evaluate 3D ultrasound volumes using Radiant DICOM software by 3\n                    surgeons. The ultrasound semantic features were correlated with histological\n                    features like tumor grade, IDH status, and MIB index.<\/jats:p><jats:p>\n          Results 68 patients were analyzed using the semantic proforma. Irregular\n                    crenated was the most common margin (63.2%) and lesions were\n                    heterogeneously hyperechoic (95.6%). Necrosis was commonly seen and\n                    noted as single (67.6%) or multiple (13.2%) in over 80%\n                    cases. A separate perilesional zone, which was predominantly hyperechoic in\n                    41.8% and both hypo and hyperechoic in 12.7%, could be\n                    identified in 54.5% of cases. Grade 4 tumors were more likely to have an\n                    irregular crenated margin (71.2%) with a single large area of necrosis,\n                    while Grade 3 tumors were likely to have smooth (31.3%) or\n                    non-characterizable margins (31.2%) with no or multiple areas of\n                    necrosis. IDH-negative tumors were more likely to have a single large focus of\n                    necrosis. Among the GBMs (52 cases), MIB labelling index of&gt;15%\n                    was associated with poorly delineated, uncharacterizable margins, when compared\n                    with MIB labelling index&lt;15% (23.5 vs. 0%),\n                    (p=0.046).<\/jats:p><jats:p>\n          Conclusion A detailed semantic proforma was developed for brain tumors and\n                    was internally validated. A few ultrasound sematic features were identified\n                    correlating with histological features in high-grade gliomas. It will require\n                    further external validation for refinement and acceptability.<\/jats:p>","DOI":"10.1055\/a-1637-9550","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:06:49Z","timestamp":1637194009000},"page":"E55-E63","source":"Crossref","is-referenced-by-count":3,"title":["Development of a Standardized Semantic Feature-Based Reporting\n                    Proforma for Intraoperative Ultrasound Findings in Brain Tumors and Application\n                    in High-Grade Gliomas \u2013 A Preliminary Study"],"prefix":"10.1055","volume":"07","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2850-402X","authenticated-orcid":false,"given":"Prakash","family":"Shetty","sequence":"additional","affiliation":[{"name":"Tata Memorial Hospital, Neurosurgery, Mumbai, India"},{"name":"Homi Bhabha National Institute, Health Sciences, Mumbai,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Tata Memorial Hospital, Neurosurgery, Mumbai, India"},{"name":"Homi Bhabha National Institute, Health Sciences, Mumbai,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Choudhari","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute, Health Sciences, Mumbai,\n                    India"},{"name":"Tata Memorial Hospital, Radiodiagnosis, Mumbai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliasgar V","family":"Moiyadi","sequence":"additional","affiliation":[{"name":"Tata Memorial Hospital, Neurosurgery, Mumbai, India"},{"name":"Homi Bhabha National Institute, Health Sciences, Mumbai,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"727","DOI":"10.4103\/0028-3886.166549","article-title":"Navigated intraoperative ultrasound for resection of gliomas: Predictive value,\n                    influence on resection and survival","volume":"63","author":"A V Moiyadi","year":"2015","journal-title":"Neurol India"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"E14","DOI":"10.3171\/2020.10.FOCUS20550","article-title":"Navigated ultrasound-based image guidance during resection of gliomas: practical\n                    utility in intraoperative decision-making and outcomes","volume":"50","author":"P Shetty","year":"2021","journal-title":"Neurosurg Focus"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"E5","DOI":"10.3171\/2015.12.FOCUS15529","article-title":"Direct navigated 3D ultrasound for resection of brain tumors: a useful tool for\n                    intraoperative image guidance","volume":"40","author":"A V Moiyadi","year":"2016","journal-title":"Neurosurg Focus"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.wneu.2020.07.044","article-title":"Customized Low-Cost Model for Hands-on Training in Intraoperative Ultrasound for\n                    Neurosurgeons: Our Experience and Review of Literature","volume":"143","author":"V Singh","year":"2020","journal-title":"World Neurosurg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1093\/ons\/opx144","article-title":"USim: A New Device and App for Case-Specific, Intraoperative Ultrasound\n                    Simulation and Rehearsal in Neurosurgery. 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