{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:05:27Z","timestamp":1781579127931,"version":"3.54.5"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose\u2002High-frequency ultrasound allows the accurate identification of neurofibromas in neurofibromatosis type 1 (NF1). This study aimed to analyze the ultrasound features of neurofibromas in children with NF1, to establish a classification based on the clinical and sonographic patterns of the different types of neurofibromas, and to evaluate the interobserver correlation coefficient (\u03ba) of this classification.<\/jats:p><jats:p>\n          Materials and Methods\u2002In this prospective, single referral center observational study, clinical and ultrasound findings of neurofibromas in children diagnosed with NF 1 were analyzed. To identify the ultrasound patterns, a cluster analysis allowing the inclusion of both clinical and ultrasound data was designed. The \u03ba coefficient was calculated using 9 external evaluators.<\/jats:p><jats:p>\n          Results\u2002265 ultrasound scans were performed on a total of 242 neurofibromas from 108 children diagnosed with NF1. Cluster analysis allowed the identification of 9 patterns (Snedecor\u02bcs F, P &lt;\u200a0.001) classified as \u201cclassic\u201d cutaneous neurofibroma, blue-red neurofibroma, pseudoatrophic neurofibroma, nodular subcutaneous neurofibroma, diffuse subcutaneous neurofibroma, congenital cutaneous neurofibroma, congenital plexiform neurofibroma, congenital diffuse and plexiform neurofibroma, and subfascial neurofibroma. The \u03ba coefficient of the interobserver ratings was 0.82.<\/jats:p><jats:p>\n          Conclusion\u2002Patterns identified in the cluster analysis allow neurofibromas to be classified with a very high interobserver correlation.<\/jats:p>","DOI":"10.1055\/a-1640-9621","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T01:41:02Z","timestamp":1637804462000},"page":"e118-e125","source":"Crossref","is-referenced-by-count":9,"title":["Clinical and Sonographic Classification of Neurofibromas in Children with Neurofibromatosis Type 1 \u2013 A Cluster Analysis"],"prefix":"10.1055","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0175-8123","authenticated-orcid":false,"given":"Francisco Javier","family":"Garc\u00eda-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Cl\u00ednica Universidad de Navarra, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Alfageme","sequence":"additional","affiliation":[{"name":"Dermatology, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Duat-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Pediatric Neurology, Hospital Infantil Universitario Ni\u00f1o\u00a0Jes\u00fas, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Mar\u00eda","family":"Andr\u00e9s Esteban","sequence":"additional","affiliation":[{"name":"Management of Bleeding Patient Unit, Hospital Universitario La Paz, Universidad Rey Juan Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7260-8718","authenticated-orcid":false,"given":"Angela","family":"Hern\u00e1ndez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1136\/jmg.2006.045906","article-title":"Guidelines for the diagnosis and management of individuals with neurofibromatosis 1","volume":"44","author":"R E Ferner","year":"2007","journal-title":"J Med Genet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1542\/peds.105.3.608","article-title":"Use of the national institutes of health criteria for diagnosis of neurofibromatosis 1 in children","volume":"105","author":"K DeBella","year":"2000","journal-title":"Pediatrics"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1182\/blood-2009-09-242875","article-title":"Mast cells and the neurofibroma microenvironment","volume":"116","author":"K 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