{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T21:31:50Z","timestamp":1771536710011,"version":"3.50.1"},"reference-count":57,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2018YCF1314000"],"award-info":[{"award-number":["2018YCF1314000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of\n                        China","doi-asserted-by":"crossref","award":["81774043"],"award-info":[{"award-number":["81774043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of\n                        China","doi-asserted-by":"crossref","award":["82074253"],"award-info":[{"award-number":["82074253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of\n                        China","doi-asserted-by":"crossref","award":["81700631"],"award-info":[{"award-number":["81700631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100019065","name":"Tianjin Science and\n                        Technology Program","doi-asserted-by":"crossref","award":["17ZXMFSY00140"],"award-info":[{"award-number":["17ZXMFSY00140"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background The pathogenesis of spontaneously diabetic Otsuka Long-Evans\n                    Tokushima Fatty (OLETF) rats, among the best models for human type 2 diabetes\n                    mellitus (T2DM), remains poorly defined. Therefore, we investigated the dynamic\n                    changes in taurine-conjugated bile acids (T-BAs) and intestinal microbiota\n                    during T2DM development in OLETF rats.<\/jats:p><jats:p>\n          Methods OLETF rats and corresponding diabetes-resistant Long Evans\n                    Tokushima Otsuka (LETO) rats were fed a normal baseline diet. The progress of\n                    T2DM was divided into four phases, including normal glycemia-normal insulinemia\n                    (baseline), normal glycemia-hyperinsulinemia, impaired glucose tolerance, and\n                    DM. Body weight, liver function, blood lipids, fasting plasma glucose, fasting\n                    plasma insulin, fasting plasma glucagon-like peptide (GLP)-1 and GLP-2, serum\n                    and fecal T-BAs, and gut microbiota were analyzed during the entire course of\n                    T2DM development.<\/jats:p><jats:p>\n          Results There were reductions in fecal T-BAs and short-chain fatty acids\n                    (SCFAs)-producing bacteria including Phascolarctobacterium and\n                        Lactobacillus in OLETF rats compared with those in LETO rats at\n                    baseline, and low levels of fecal T-BAs and SCFAs-producing bacteria were\n                    maintained throughout the whole course of the development of T2DM among OLETF\n                    rats compared with those in corresponding age-matched LETO rats. Fecal\n                    taurine-conjugated chenodeoxycholic acid correlated positively with\n                        Phascolarctobacterium. Fecal taurine-conjugated deoxycholic acid\n                    correlated positively with Lactobacillus and fasting plasma GLP-1 and\n                    inversely with fasting plasma glucose.<\/jats:p><jats:p>\n          Conclusion The fecal BAs profiles and microbiota structure among OLETF\n                    rats were different from those of LETO rats during the entire course of T2DM\n                    development, indicating that reductions in intestinal T-BAs and specific\n                    SCFA-producing bacteria may be potential mechanisms of T2DM in OLETF rats.<\/jats:p>","DOI":"10.1055\/a-1643-1689","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T23:36:18Z","timestamp":1640043378000},"page":"237-247","source":"Crossref","is-referenced-by-count":6,"title":["Reductions in Intestinal Taurine-Conjugated Bile Acids and\n                    Short-Chain Fatty Acid-Producing Bacteria Might be Novel Mechanisms of Type 2\n                    Diabetes Mellitus in Otsuka Long-Evans Tokushima Fatty Rats"],"prefix":"10.1055","volume":"130","author":[{"given":"Xiaoyun","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingli","family":"Cheng","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory\n                    of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute\n                    of Endocrinology, Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jintong","family":"Hao","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory\n                    of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute\n                    of Endocrinology, Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Han","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory\n                    of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute\n                    of Endocrinology, Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory\n                    of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute\n                    of Endocrinology, Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory\n                    of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute\n                    of Endocrinology, Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Shan","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory\n                    of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute\n                    of Endocrinology, Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Wang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory\n                    of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute\n                    of Endocrinology, Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhui","family":"Yang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory\n                    of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute\n                    of Endocrinology, Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhong","family":"Yang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory\n                    of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute\n                    of Endocrinology, Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baocheng","family":"Chang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory\n                    of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute\n                    of Endocrinology, Tianjin Medical University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(11)60679-X","article-title":"National, regional, and global trends in fasting plasma glucose and diabetes\n                    prevalence since 1980: systematic analysis of health examination surveys and\n                    epidemiological studies with 370 country-years and 2\u00b77 million\n                    participants","volume":"378","author":"G Danaei","year":"2011","journal-title":"The Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S2213-8587(13)70112-8","article-title":"Diabetes: A 21st century challenge","volume":"2","author":"P Z 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