{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:13:00Z","timestamp":1779185580424,"version":"3.51.4"},"reference-count":113,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Hintergrund\u2002Die chronische Rhinosinusitis mit Nasenpolypen (CRSwNP) ist eine multifaktorielle entz\u00fcndliche Erkrankung der paranasalen Schleimh\u00e4ute, der als Endotyp meistens eine TH2-Inflammation zugrunde liegt. IgE-Antik\u00f6rper spielen dabei eine wichtige Rolle. Der anti-IgE-Antik\u00f6rper Omalizumab wurde im August 2020 f\u00fcr die Therapie der schweren CRSwNP zugelassen.<\/jats:p><jats:p>Methoden\u2002In einer Literatursuche wurde die Immunologie der CRSwNP analysiert und die Evidenz zur Wirkung von Omalizumab bei dieser Erkrankung ermittelt durch Recherchen in Medline, Pubmed sowie den nationalen und internationalen Studien- und Leitlinien-Registern und der Cochrane Library.<\/jats:p><jats:p>Ergebnisse\u2002Basierend auf diesen Angaben aus der internationalen Literatur werden von einem Expertengremium Empfehlungen f\u00fcr die Anwendung von Omalizumab bei CRSwNP im deutschen Gesundheitssystem gegeben.<\/jats:p><jats:p>Schlussfolgerung\u2002Omalizumab ist zugelassen f\u00fcr Patienten ab 18 Jahren mit schwerer chronischer Rhinosinusitis mit Nasenpolypen als Zusatztherapie zu intranasalen Kortikosteroiden (INCS), wenn durch eine Therapie mit INCS keine ausreichende Krankheitskontrolle erzielt werden kann.<\/jats:p>","DOI":"10.1055\/a-1644-4066","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T22:48:08Z","timestamp":1633042088000},"page":"952-963","source":"Crossref","is-referenced-by-count":16,"title":["Positionspapier: Empfehlungen zur Anwendung von Omalizumab bei\u00a0chronischer Rhinosinusitis mit Polyposis nasi (CRSwNP) im deutschen Gesundheitssystem \u2013 Empfehlungen des \u00c4rzteverbandes Deutscher Allergologen (AeDA) und der AGs Klinische Immunologie, Allergologie und Umweltmedizin und Rhinologie und Rhinochirurgie der Deutschen Gesellschaft f\u00fcr HNO-Heilkunde, Kopf- und Halschirurgie (DGHNOKHC)"],"prefix":"10.1055","volume":"100","author":[{"given":"L.","family":"Klimek","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Rhinologie und Allergologie, Wiesbaden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"F\u00f6rster-Ruhrmann","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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