{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:32:59Z","timestamp":1782207179109,"version":"3.54.5"},"reference-count":47,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Vice Chancellor of Research\n                    and Technology of Hamadan University of Medical Sciences","award":["9612228342"],"award-info":[{"award-number":["9612228342"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective Aluminum phosphide (AlP) is widely used to protect stored food\n                    products and grains from pests and rodents. The availability of AlP, especially\n                    in Asian countries it has become a desirable factor to commit suicide. The\n                    phosphine produced from ALP is a very reactive radical and a respiratory\n                    inhibitor that causes oxidative damage. There is no dedicated antidote or\n                    effective drug to manage AlP-induced lung toxicity. The present study aims to\n                    evaluate and compare the protective effects of curcumin and nanocurcumin on\n                    ALP\u2011induced subacute lung injury and determine the underlying mechanism.<\/jats:p><jats:p>\n          Methods Rats were exposed to AlP (2\u2009mg\/kg\/day,\n                    orally)+curcumin or nanocurcumin (100\u2009mg\/kg\/day,\n                    orally) for 7 days. Then rats were anesthetized and lung tissues were collected.\n                    Oxidative stress biomarkers, genes expression of antioxidant enzymes,\n                    participated genes in the SIRT1\/FOXO3 pathway, and lung histopathology\n                    were assessed by biochemical and ELISA methods, Real-Time PCR analysis, and\n                    H&amp;E staining.<\/jats:p><jats:p>\n          Results Curcumin and nanocurcumin produced a remarkable improvement in\n                    AlP-induced lung damage through reduction of MDA, induction of antioxidant\n                    capacity (TAC, TTG) and antioxidant enzymes (CAT, GPx), modulation of\n                    histopathological changes, and up-regulation of genes expression of SIRT1,\n                    FOXO3, FOXO1 in lung tissue.<\/jats:p><jats:p>\n          Conclusion Nanocurcumin had a significantly more protective effect than\n                    curcumin to prevent AlP-induced lung injury via inhibition of oxidative stress.\n                    Nanocurcumin could be considered a suitable therapeutic choice for AlP\n                    poisoning.<\/jats:p>","DOI":"10.1055\/a-1647-2418","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T01:12:19Z","timestamp":1633569139000},"page":"100-108","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of Protective Effects of Curcumin and Nanocurcumin on\n                    Aluminium Phosphide\u2011Induced Subacute Lung Injury in Rats: Modulation of\n                    Oxidative Stress through SIRT1\/FOXO3 Signalling Pathway"],"prefix":"10.1055","volume":"72","author":[{"given":"Mohammad Ali","family":"Mahlooji","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy,\n                    Medicinal Plants and Natural Products Research Center, Hamadan University of\n                    Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Heshmati","sequence":"additional","affiliation":[{"name":"Nutrition Health Research Center, Hamadan University of Medical\n                    Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nejat","family":"Kheiripour","sequence":"additional","affiliation":[{"name":"Research Center for Biochemistry and Nutrition in Metabolic Diseases,\n                    Kashan University of Medical Sciences, Kashan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Abadan University of Medical\n                    Sciences, Abadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Soleimani","family":"Asl","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences, Faculty of Medicine, Hamadan\n                    University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghasem","family":"Solgi","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, Hamadan University of\n                    Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6247-4816","authenticated-orcid":false,"given":"Akram","family":"Ranjbar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy,\n                    Medicinal Plants and Natural Products Research Center, Hamadan University of\n                    Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2712-2799","authenticated-orcid":false,"given":"Asieh","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Razi Drug Research Center, Iran University of Medical Sciences, Tehran,\n                    Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.forsciint.2011.06.018","article-title":"Phosphide poisoning: a review of literature","volume":"214","author":"G S Bumbrah","year":"2012","journal-title":"Forensic Sci Int"},{"key":"ref2","first-page":"81","article-title":"Aluminum phosphide poisoning in animals","volume":"5","author":"S Shakeri","year":"2014","journal-title":"Int J Med Toxicol Forensic Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1515\/aiht-2016-67-2784","article-title":"A review of aluminium phosphide poisoning and a flowchart to treat it","volume":"67","author":"B Hashemi-Domeneh","year":"2016","journal-title":"Arh Hig Rada 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