{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T18:31:44Z","timestamp":1711909904632},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Secondary sclerosing cholangitis (SSC) is a severe complication of intensive care treatment in critically ill patients. It is characterized by rapid onset and severe chlolestasis with elevation of gGT. In contrast to primary sclerosing cholangitis, SSC-CIP has a distinct and timely well defined trigger and can have a rapid progress to cirrhosis and liver failure.  In context of the COVID-19-pandemic, there are reports about patients, who developed SSC after a severe COVID-infection and intensive care treatment.<\/jats:p><jats:p>We report on a 62-year old patient without any relevant pre-existing illnesses, who suffered from severe COVID-19 pneumonia with the need for long term ventilation. In the course of the disease he developed a critical-illness-polyneuropathy a pronounced cholestasis. After recovery from COVID-pneumonia, the PNP regressed but the cholestasis progressed. MRCP showed only irregular intrahepatic bile ducts, while EUS showed echogenic  intraductal longitudinal structures characteristic for intraductal casts and for SSC-CIP. This was confirmed with ERC, where the complete necrotic bile ducts could be extracted and retrieved for histological and molecular analysis.<\/jats:p><jats:p>The patient was included in a scheduled ERC-program to prevent a progress of SSC and the concomitant cirrhosis.<\/jats:p><jats:p>SSC is an often missed diagnosis, which obviously can also occur in COVID-patients. In case of elevated liver function tests with cholestasis, EUS might be the key diagnostic method to characterize intraductal casts and identify those patients who should undergo ERC.<\/jats:p>","DOI":"10.1055\/a-1647-3785","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T23:49:37Z","timestamp":1634687377000},"page":"1304-1308","source":"Crossref","is-referenced-by-count":4,"title":["Corona again? SSC after a severe COVID-disease"],"prefix":"10.1055","volume":"59","author":[{"given":"Benno","family":"Arnstadt","sequence":"additional","affiliation":[{"name":"Klinikum Garmisch-Partenkirchen GmbH, Garmisch-Partenkirchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Zillinger","sequence":"additional","affiliation":[{"name":"MVZ Dorfen, Dorfen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Treitl","sequence":"additional","affiliation":[{"name":"BGU Hospital Murnau, Murnau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Dieter","family":"Allescher","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Innere Medizin, Gastroent., Hepatologie u. Stoffwechsel, Klinikum Garmisch-Partenkirchen, Garmisch-Partenkirchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1001\/archsurg.1970.01340230012003","article-title":"Mechanism of hepatic dysfunction following shock and trauma","volume":"100","author":"G Nunes","year":"1970","journal-title":"Arch Surg"},{"key":"ref2","first-page":"657","article-title":"A clinicopathologic study of hepatic dysfunction following shock","volume":"142","author":"HR Champion","year":"1976","journal-title":"Surg Gynecol Obstet"},{"key":"ref3","first-page":"174","article-title":"Benign postoperative jaundice complicating severe trauma","volume":"86","author":"S Hartley","year":"1977","journal-title":"N Z Med J"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1159\/000501405","article-title":"Secondary sclerosing 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