{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:08:31Z","timestamp":1778976511905,"version":"3.51.4"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to test whether mildly elevated bilirubin levels in preterm infants are associated with increased signal intensity (SI) on magnetic resonance imaging (MRI) of the basal ganglia (BG).<\/jats:p><jats:p>\n            Study Design\u2003MRI was performed at term equivalent age in 55 postpreterm infants using a neonatal MRI 1-T scanner. SI of the BG was correlated with mild hyperbilirubinemia.<\/jats:p><jats:p>\n            Results\u2003BG MRI SI was significantly increased in infants with mild hyperbilirubinemia on T1-weighted image (T1; p\u2009=\u20090.0393) and T2-weighted image (T2; p\u2009=\u20090.0309). We found no effect of gestational age or sepsis on BG MRI intensity; however, there was a significant effect of acidosis on T1 (p\u2009=\u20090.0223) but not on T2 (p\u2009=\u20090.2316). Infants with combined hyperbilirubinemia and acidosis had the most significant increase in SI on both T1 and T2 respectively (p\u2009=\u20090.0072 and 0.0195, respectively).<\/jats:p><jats:p>\n            Conclusion\u2003We found a positive association between increased BG MRI SI and mildly elevated bilirubin levels. The effect was greatly strengthened when hyperbilirubinemia was associated with acidosis.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1649-1918","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T12:28:46Z","timestamp":1634041726000},"page":"1467-1472","source":"Crossref","is-referenced-by-count":2,"title":["Mildly Elevated Bilirubin Levels are Associated with Increased Magnetic Resonance Imaging Signal Intensity in the Basal Ganglia of Preterm Neonates"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2227-1074","authenticated-orcid":false,"given":"Yair","family":"Kasirer","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel"},{"name":"Department of Pediatrics, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alona","family":"Bin-Nun","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel"},{"name":"Department of Pediatrics, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Hammerman","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel"},{"name":"Department of Pediatrics, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ortal B.","family":"Yosef","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelan","family":"Marianayagam","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Weill Cornell Medical Center \u2013 New York Presbyterian Hospital, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2248-1717","authenticated-orcid":false,"given":"Aliza","family":"Hammerman-Rozenberg","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Shchors","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliel","family":"Ben-David","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Hebrew University of 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