{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:28:57Z","timestamp":1760956137083,"version":"3.37.3"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study was to test a hypothesis that baseline systemic vascular resistance index (SVRI) assessed by method of transpulmonary thermodilution predicts perioperative requirement for vasoactive drugs. The primary outcomes were: (1) peak vasoactive-inotropic score (VIS) and (2) peak dose of hypotensive drugs at any stage of surgery. The main exposure variable was baseline SVRI. Hemodynamics were retrospectively assessed by transpulmonary thermodilution in 50 adults who had undergone posterior retroperitoneal surgery for pheochromocytoma. Univariate linear regression analysis showed predictive value of SVRI on VIS [regression coefficient, 95% CI; 0.024 (0.005, 0.4), p=0.015]. Other significant factors were the history of peak diastolic pressure, baseline MAP, baseline betablocker therapy, and history of coronary artery disease (CAD). After adjustment of SVRI for the history of CAD, its prognostic value became non-significant [0.018 (0.008, 0.03), p=0.063 and 29.6 (19, 40.2), p=0.007 for SVRI and history of CAD, respectively]. Requirements of vasodilators were predicted by baseline adrenergic activity [0.37 (0.005, 0.74), p=0.047]. In conclusion, baseline SVRI is associated with perioperative requirement of vasopressor drugs, but history of CAD is a stronger prognostic factor for vasopressor support. Perioperative requirement in vasodilators is associated with baseline adrenergic activity.<\/jats:p>","DOI":"10.1055\/a-1651-5975","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T23:59:36Z","timestamp":1636156776000},"page":"717-722","source":"Crossref","is-referenced-by-count":2,"title":["Predictors of Perioperative Vasoactive Drug Requirement During Retroperitoneal Adrenalectomy for Pheochromocytoma: A Retrospective Exploratory Study"],"prefix":"10.1055","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5643-5204","authenticated-orcid":false,"given":"Mikhail","family":"Alexeev","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Saint-Petersburg State University Hospital, St. Petersburg, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Kuleshov","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Saint-Petersburg State University Hospital, St. Petersburg, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisei","family":"Fedorov","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Saint-Petersburg State University Hospital, St. Petersburg, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirill","family":"Gorokhov","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Saint-Petersburg State University Hospital, St. Petersburg, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Rusakov","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Saint-Petersburg State University Hospital, St. Petersburg, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Ionova","sequence":"additional","affiliation":[{"name":"Quality of Life and Monitoring Unit, Saint-Petersburg State University Hospital, St. Petersburg, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Nikitina","sequence":"additional","affiliation":[{"name":"Quality of Life and Monitoring Unit, Saint-Petersburg State University Hospital, St. Petersburg, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5581-9169","authenticated-orcid":false,"given":"Sergey","family":"Efremov","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Saint-Petersburg State University Hospital, St. Petersburg, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4103\/2230-8210.86977","article-title":"Implications and considerations during pheochromocytoma resection: A challenge to the anesthesiologist","volume":"15","author":"S Bajwa","year":"2011","journal-title":"Indian J Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1245\/s10434-015-4519-y","article-title":"Hemodynamic stability during pheochromocytoma resection: Lessons learned over the last two 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