{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T06:03:32Z","timestamp":1648793012462},"reference-count":60,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Neue Erkenntnisse bringen Fortschritte in das Verst\u00e4ndnis der komplizierten \u00c4tiopathogenese\n      der Interstitiellen Zystitis\/Bladder Pain Syndrom (IC\/BPS), deren Kausalit\u00e4ten bisher nur in\n      Fragmenten entschl\u00fcsselt wurden. Dabei zeigt sich ein immer komplexeres Netzwerk von\n      Pathomechanismen, in denen die oft genannten Mastzellen und Urothelver\u00e4nderungen nur ein\n      Fragment der pathologischen Ver\u00e4nderungen zu sein scheinen. Neueste Erkenntnisse f\u00fcr eine\n      m\u00f6gliche genetische und epigenetische Veranlagung basieren auf Stammbaumanalysen, Nachweisen\n      von Einzelnukleotid-Polymorphismen und eindeutigen Ver\u00e4nderungen bei Differentiell\n      Exprimierten Genen. Multiple Ver\u00e4nderungen lassen sich auf molekularer Ebene nachweisen. Der\n      Pl\u00e4ttchenaktivierende Faktor, VEGF, das Corticotropin Releasing Hormone und das Inflammasom\n      sind wichtige Player im Verst\u00e4ndnis der Erkrankung. Der Pathomechanismus der \u201eAktivierung\u201c der\n      IC\/BPS bleibt immer noch ungekl\u00e4rt. Neue Ansatzpunkte k\u00f6nnten Virusnachweise (Epstein-Barr\n      Virus, BK Polyomaviren) oder bakterielle Entz\u00fcndungen durch in Standardkulturen nicht\n      nachweisbaren Erregern geben.<\/jats:p>","DOI":"10.1055\/a-1652-1162","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T23:42:43Z","timestamp":1638315763000},"page":"539-546","source":"Crossref","is-referenced-by-count":0,"title":["Interstitielle Zystitis: Was gibt es Neues zur \u00c4tiopathogenese?"],"prefix":"10.1055","volume":"52","author":[{"given":"Andreas","family":"Gonsior","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Urologie, Universit\u00e4tsklinikum Leipzig, Leipzig, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Neuhaus","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Urologie, Universit\u00e4tsklinikum Leipzig, Leipzig, 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