{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:28:50Z","timestamp":1783420130461,"version":"3.54.6"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"09\/10","funder":[{"DOI":"10.13039\/100000064","name":"National Center for Complementary and Alternative Medicine","doi-asserted-by":"crossref","award":["R15 AT010191"],"award-info":[{"award-number":["R15 AT010191"]}],"id":[{"id":"10.13039\/100000064","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000064","name":"National Center for Complementary and Alternative Medicine","doi-asserted-by":"crossref","award":["T32 AT008938"],"award-info":[{"award-number":["T32 AT008938"]}],"id":[{"id":"10.13039\/100000064","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["K12GM139186"],"award-info":[{"award-number":["K12GM139186"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plants have a long history of use for their medicinal properties. The complexity of botanical extracts presents unique challenges and necessitates the application of innovative approaches to correctly identify and quantify bioactive compounds. For this study, we used untargeted metabolomics to explore the antimicrobial activity of Rumex crispus (yellow dock), a member of the Polygonaceae family used as an herbal remedy for bacterial infections. Ultra-performance liquid chromatography coupled with high resolution mass-spectrometry (UPLC-MS) was used to identify and quantify the known antimicrobial compound emodin. In addition, we used biochemometric approaches to integrate data measuring antimicrobial activity from R.\u00a0crispus root starting material and fractions against methicillin-resistant Staphylococcus aureus (MRSA) with UPLC-MS data. Our results support the hypothesis that multiple constituents, including the anthraquinone emodin, contribute to\n\t\t\t\t\tthe antimicrobial activity of R.\u00a0crispus against MRSA.<\/jats:p>","DOI":"10.1055\/a-1652-1547","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T22:38:38Z","timestamp":1635201518000},"page":"753-761","source":"Crossref","is-referenced-by-count":7,"title":["More Than Just a Weed: An Exploration of the Antimicrobial Activity of Rumex crispus using a Multivariate Data Analysis Approach"],"prefix":"10.1055","volume":"88","author":[{"given":"Chantal V.","family":"Pelzer","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro NC, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Houriet","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro NC, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Crandall","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro NC, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Todd","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro NC, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6773-746X","authenticated-orcid":false,"given":"Nadja B.","family":"Cech","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro NC, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0182-0436","authenticated-orcid":false,"suffix":"Jr.","given":"Derick D.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro NC, United States"},{"name":"Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago IL, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.imr.2018.03.005","article-title":"Integration of botanicals in contemporary medicine: Road blocks, checkpoints and go-ahead signals","volume":"7","author":"N A Chugh","year":"2018","journal-title":"Integr Med 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