{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:02:10Z","timestamp":1740168130592,"version":"3.37.3"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"TUMS coded","award":["98-01-159-41735"],"award-info":[{"award-number":["98-01-159-41735"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Aluminum phosphide (AlP) toxicity is associated with a high\n                    risk of death due to heart, liver, and kidney failure as the target organs.\n                    Phosphine gas released due to the ingestion is the main factor involved in the\n                    multi-organ failure with various mechanisms. Levosimendan (LEV) is a calcium\n                    sensitizer with a pleiotropic effect on multiple organs. This study aimed to\n                    investigate whether LEV can alleviate AlP-induced nephrotoxicity in the rat\n                    model.<\/jats:p><jats:p>\n          Method Six groups included control group (almond oil only), sole LEV group\n                    (48\u2009\u00b5g\/kg), AlP group\n                    (LD50=10\u2009\u00b5g\/kg), and the poisoned groups treated\n                    with LEV at doses of 12, 24, and 48\u2009\u00b5g\/kg 30\u2009min\n                    after AlP gavage. After 24\u2009hours of treatment, serum and kidney samples\n                    were taken for biochemical and histopathological analyses.<\/jats:p><jats:p>\n          Result Biochemical analysis of the AlP group showed that the activity of\n                    complexes I, II, and IV was significantly reduced, while the levels of lipid\n                    peroxidation (LPO) and reactive oxygen species (ROS), lactate, and\n                    myeloperoxidase (MPO) activity significantly increased. Also, AlP reduced live\n                    renal cells and elevated necrosis. However, the levels of serum creatinine and\n                    blood urea nitrogen were not affected by the poisoning. LEV co-treatment could\n                    increase mitochondrial complex activity and reduce MPO activity, LPO, ROS, and\n                    lactate levels. Additionally, the histopathological analysis showed the\n                    detrimental effects of AlP on kidney tissue, which was mitigated by LEV\n                    administration.<\/jats:p><jats:p>\n          Conclusion Our findings showed that LEV can potentially improve oxidative\n                    stress, imbalance in the redox status, necrosis, and pathological injuries in\n                    kidney tissue following AlP-poisoning.<\/jats:p>","DOI":"10.1055\/a-1661-5439","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T23:59:20Z","timestamp":1637193560000},"page":"109-118","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Levosimendan on Phosphine-Induced Nephrotoxicity:\n                    Biochemical and Histopathological Assessment"],"prefix":"10.1055","volume":"72","author":[{"given":"Maryam","family":"Baeeri","sequence":"first","affiliation":[{"name":"Department of Toxicology and Pharmacology, Faculty of Pharmacy, and\n                    Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC),\n                    The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical\n                    Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahban","family":"Rahimifard","sequence":"first","affiliation":[{"name":"Department of Toxicology and Pharmacology, Faculty of Pharmacy, and\n                    Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC),\n                    The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical\n                    Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5564-2778","authenticated-orcid":false,"given":"Maryam","family":"Armandeh","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, Faculty of Pharmacy, and\n                    Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC),\n                    The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical\n                    Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnaz","family":"Bameri","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, Faculty of Pharmacy, and\n                    Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC),\n                    The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical\n                    Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madiha","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, Faculty of Pharmacy, and\n                    Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC),\n                    The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical\n                    Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Haghi-Aminjan","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Ardabil University of Medical\n                    Sciences, Ardabil, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramtin","family":"Farhadi","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, Faculty of Pharmacy, and\n                    Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC),\n                    The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical\n                    Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, Faculty of Pharmacy, and\n                    Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC),\n                    The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical\n                    Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"ref1","first-page":"182","article-title":"Pesticide poisoning","volume":"20","author":"A Goel","year":"2007","journal-title":"National Medical Journal of India"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.etap.2018.09.008","article-title":"The role of minocycline in alleviating aluminum phosphide-induced cardiac\n                    hemodynamic and renal 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1661-5439.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T13:18:49Z","timestamp":1720012729000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1661-5439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,17]]},"references-count":36,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2022,1,27]]},"published-print":{"date-parts":[[2022,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1661-5439","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"type":"print","value":"2194-9379"},{"type":"electronic","value":"2194-9387"}],"subject":[],"published":{"date-parts":[[2021,11,17]]}}}