{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:51:48Z","timestamp":1792644708912,"version":"4.5.0"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Orthop Unfall"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Arbeitsgemeinschaft \u201eKlinische Geweberegeneration\u201c hat bereits in den Jahren 2004, 2013 und 2016 Empfehlungen in Bezug auf die Indikation f\u00fcr verschiedene knorpelregenerative Verfahren\n          zur Behandlung von Knorpelsch\u00e4den am Kniegelenk publiziert. Auf Basis neuer wissenschaftlicher Erkenntnisse sollen in der vorliegenden Arbeit diese Empfehlungen auch unter Einbeziehung neuer\n          Behandlungsverfahren aktualisiert werden. Die Einsch\u00e4tzung folgt damit dem Prinzip der besten verf\u00fcgbaren Evidenz und ber\u00fccksichtigt \u00fcber prospektiv randomisierte Studien hinaus auch Studien\n          mit niedrigerem Evidenzniveau. An Stellen fehlender publizierter Evidenz basiert die Entscheidung hier auf einem Konsensusprozess innerhalb der Mitglieder der AG Klinische\n          Geweberegeneration.<\/jats:p>\n                  <jats:p>Das Prinzip der bereits vorausgehend publizierten Arbeiten bleibt auch in den neuen Empfehlungen erhalten. Kleine Knorpelsch\u00e4den sind nach Ansicht der Arbeitsgruppe f\u00fcr eine\n          Knochenmarkstimulation zug\u00e4nglich, die matrixassoziierte autologe Chondrozytentransplantation (mACT) ist f\u00fcr gr\u00f6\u00dfere Knorpelsch\u00e4den die Methode der Wahl. Auf Basis neuerer Daten wird jedoch\n          die Indikationsgrenze f\u00fcr die mACT auf 2,0 cm2 reduziert. Zus\u00e4tzlich zur arthroskopischen Mikrofrakturierung wird auch die matrixaugmentierte Knochenmarkstimulation in die\n          Empfehlung als Standardverfahren aufgenommen (empfohlene Defektgr\u00f6\u00dfe 1\u20134,5 cm2). F\u00fcr die Therapie kleinerer osteochondraler Defekte wird neben der osteochondralen Transplantation\n          (OCT) auch die matrixaugmentierte Knochenmarkstimulation empfohlen. Bei gr\u00f6\u00dferen Defekten eignet sich die autologe Knorpelzelltransplantation (mACT) in Kombination mit einer Rekonstruktion\n          des subchondralen Knochens.<\/jats:p>","DOI":"10.1055\/a-1663-6807","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:06:13Z","timestamp":1645470373000},"page":"57-64","source":"Crossref","is-referenced-by-count":51,"title":["Empfehlungen der AG Klinische Geweberegeneration zur Behandlung von Knorpelsch\u00e4den am Kniegelenk"],"prefix":"10.1055","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-3733","authenticated-orcid":false,"given":"Philipp","family":"Niemeyer","sequence":"additional","affiliation":[{"name":"OCM Orthop\u00e4dische Chirurgie M\u00fcnchen, M\u00fcnchen, Deutschland"},{"name":"Klinik f\u00fcr Orthop\u00e4die und Unfallchirurgie, Albert-Ludwigs-Universit\u00e4t Freiburg, Freiburg im Breisgau, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Chirurgie, Klinik im Kronprinzenbau, Reutlingen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-1687","authenticated-orcid":false,"given":"Matthias","family":"Aurich","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Orthop\u00e4die, Unfall- und Wiederherstellungschirurgie, Universit\u00e4tsklinikum Halle (Saale), Halle (Saale), Deutschland"},{"name":"Klinik f\u00fcr Unfall- und Wiederherstellungschirurgie, BG Klinikum Bergmannstrost Halle, Halle (Saale, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Becher","sequence":"additional","affiliation":[{"name":"HKF - Internationales Zentrum f\u00fcr H\u00fcft-, Knie- und Fu\u00dfchirurgie, ATOS Klinik Heidelberg, Heidelberg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Behrens","sequence":"additional","affiliation":[{"name":"Orthop\u00e4die, CUNO, Hamburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bichmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Unfallchirurgie und Orthop\u00e4die, Nordwest Krankenhaus Sanderbusch GmbH, Sande, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"Bode","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Orthop\u00e4die und Unfallchirurgie, Albert-Ludwigs-Universit\u00e4t Freiburg, Freiburg im Breisgau, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Brucker","sequence":"additional","affiliation":[{"name":"Orthop\u00e4die, Orthoplus, M\u00fcnchen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Erggelet","sequence":"additional","affiliation":[{"name":"alphaclinic z\u00fcrich, Universit\u00e4t Freiburg, Z\u00fcrich, Schweiz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ezechieli","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Orthop\u00e4die, Unfallchirurgie und Sporttraumatologie, St. Josefs Krankenhaus Salzkotten, Salzkotten, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svea","family":"Faber","sequence":"additional","affiliation":[{"name":"Orthop\u00e4dische Chirurgie, OCM Klinik M\u00fcnchen, M\u00fcnchen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Fickert","sequence":"additional","affiliation":[{"name":"University Medical Center Mannheim Medical Faculty Mannheim, Heidelberg University, Sportorthopaedicum Regensburg\/Straubing, Straubing, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Fritz","sequence":"additional","affiliation":[{"name":"Orthop\u00e4die und Unfallchirurgie, Orthop\u00e4disch Chirurgisches Centrum, T\u00fcbingen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnd","family":"Hoburg","sequence":"additional","affiliation":[{"name":"Gelenk- und Wirbels\u00e4ulenzentrum, Gelenk- und Wirbels\u00e4ulenzentrum Steglitz-Berlin, Berlin, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kreuz","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Orthop\u00e4die und Unfallchirurgie, Asklepios Stadtklinik Bad Tolz, Bad T\u00f6lz, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7162-828X","authenticated-orcid":false,"given":"J\u00f6rg","family":"L\u00fctzner","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Orthop\u00e4die, Universit\u00e4tsklinikum Carl Gustav Carus Dresden, Dresden, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Madry","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Experimentelle Orthop\u00e4die, Universit\u00e4tsklinikum des Saarlandes, Homburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Marlovits","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Unfallchirurgie, Medizinische Universit\u00e4t Wien, Wien, \u00d6sterreich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Mehl","sequence":"additional","affiliation":[{"name":"Abteilung und Poliklinik f\u00fcr Sportorthop\u00e4die, Klinikum rechts der Isar, TUM, M\u00fcnchen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Orthop\u00e4dische Klinik, Ludwig-Maximiliams-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Nehrer","sequence":"additional","affiliation":[{"name":"Fakult\u00e4t f\u00fcr Gesundheit und Medizin, Donau-Universit\u00e4t Krems, Krems, \u00d6sterreich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Niethammer","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Orthop\u00e4die, Physikalische Medizin und Rehabilitation, Ludwig-Maximilians-Universit\u00e4t, M\u00fcnchen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Pietschmann","sequence":"additional","affiliation":[{"name":"Orthop\u00e4dische Klinik, Ludwig-Maximiliams-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0568-2074","authenticated-orcid":false,"given":"Christian","family":"Plaass","sequence":"additional","affiliation":[{"name":"Diakovere Annastift, Klinik f\u00fcr Orthop\u00e4die, Medizinische Hochschule Hannover, Hannover, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"R\u00f6ssler","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Orthop\u00e4die und Unfallchirurgie, Universit\u00e4tsklinikum Bonn, Bonn, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Rhunau","sequence":"additional","affiliation":[{"name":"Orthopedics, Viktoria Klinik Bochum, Bochum, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Schewe","sequence":"additional","affiliation":[{"name":"Orthop\u00e4disch Chirurgisches Centrum, Orthop\u00e4disch Chirurgisches Centrum T\u00fcbingen, T\u00fcbingen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter","family":"Spahn","sequence":"additional","affiliation":[{"name":"Unfallchirurgie und Orthop\u00e4die, Praxisklinik f\u00fcr Unfallchirurgie und Orthop\u00e4die, Eisenach, Deutschland"},{"name":"Klinik f\u00fcr Unfall,- Hand- und Wiederherstellungschirurgie, Universit\u00e4tsklinikum Jena, Jena, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Steinwachs","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Orthobiologie und Knorpelregeneration, Schulthess Klinik, Z\u00fcrich, Schweiz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tischer","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery, University Medicine Rostock, Rostock, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Volz","sequence":"additional","affiliation":[{"name":"Orthop\u00e4die & Unfallchirurgie, Sportklinik Ravensburg, Ravensburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Walther","sequence":"additional","affiliation":[{"name":"Foot and Ankle Surgery, Sch\u00f6n Klinik M\u00fcnchen Harlaching, M\u00fcnchen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Zinser","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Orthop\u00e4die und Unfallchirurgie, St. Vinzenz-Hospital Dinslaken, Dinslaken, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Zellner","sequence":"additional","affiliation":[{"name":"sporthopaedicum Regensburg, Regensburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Angele","sequence":"additional","affiliation":[{"name":"sporthopaedicum Regensburg, Regensburg, Deutschland"},{"name":"Universit\u00e4tsklinikum Regensburg, Regensburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1055\/s-2004-832353","article-title":"Indikations- und Durchf\u00fchrungsempfehlungen der Arbeitsgemeinschaft \u201eGeweberegeneration und Gewebeersatz\u201c zur Autologen Chondrozyten-Transplantation (ACT)","volume":"142","author":"P Behrens","year":"2004","journal-title":"Z Orthop Ihre Grenzgeb"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1055\/s-0032-1328207","article-title":"Stellenwert der autologen Chondrozytentransplantation (ACT) in der Behandlung von Knorpelsch\u00e4den des Kniegelenks \u2013 Empfehlungen der AG Klinische Geweberegeneration der DGOU","volume":"151","author":"P Niemeyer","year":"2013","journal-title":"Z Orthop Unfall"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.knee.2016.02.001","article-title":"Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group \u201cClinical Tissue Regeneration\u201d of the German Society of Orthopaedics and\n          Trauma (DGOU)","volume":"23","author":"P Niemeyer","year":"2016","journal-title":"Knee"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1055\/a-0591-6457","article-title":"Stellenwert der matrixaugmentierten Knochenmarkstimulation in der Behandlung von Knorpelsch\u00e4den des Kniegelenks: Konsensusempfehlungen der AG Klinische Geweberegeneration der DGOU","volume":"156","author":"P Niemeyer","year":"2018","journal-title":"Z Orthop Unfall"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1177\/0363546508330137","article-title":"Increased failure rate of autologous chondrocyte implantation after previous treatment with marrow stimulation techniques","volume":"37","author":"T Minas","year":"2009","journal-title":"Am J Sports Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1177\/0363546511425651","article-title":"Clinical outcome of autologous chondrocyte implantation for failed microfracture treatment of full-thickness cartilage defects of the knee joint","volume":"40","author":"JM Pestka","year":"2012","journal-title":"Am J Sports Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s00167-010-1054-z","article-title":"The basic science of the subchondral bone","volume":"18","author":"H Madry","year":"2010","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1177\/0363546507311095","article-title":"Characterized Chondrocyte Implantation Results in Better Structural Repair When Treating Symptomatic Cartilage Defects of the Knee in a Randomized Controlled Trial versus\n          Microfracture","volume":"36","author":"DBF Saris","year":"2008","journal-title":"Am J Sports Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/j.joca.2006.05.003","article-title":"Results after microfracture of full-thickness chondral defects in different compartments in the knee","volume":"14","author":"PC Kreuz","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"S 01","key":"ref10","doi-asserted-by":"publisher","first-page":"10S","DOI":"10.1177\/0363546509350694","article-title":"Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to\n          microfracture","volume":"37","author":"DBF Saris","year":"2009","journal-title":"Am J Sports Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1177\/0363546518756976","article-title":"Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture: Five-Year Follow-up of a Prospective Randomized Trial","volume":"46","author":"M Brittberg","year":"2018","journal-title":"Am J Sports Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/1947603519897290","article-title":"Matrix-Associated Autologous Chondrocyte Implantation with Spheroid Technology Is Superior to Arthroscopic Microfracture at 36 Months Regarding Activities of Daily Living and Sporting\n          Activities after Treatment","author":"A Hoburg","year":"2020","journal-title":"Cartilage"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2325967119877847","DOI":"10.1177\/2325967119877847","article-title":"Matrix-Associated Chondrocyte Implantation Is Associated With Fewer Reoperations Than Microfracture: Results of a Population-Representative, Matched-Pair Claims Data Analysis for Cartilage\n          Defects of the Knee","volume":"7","author":"P Niemeyer","year":"2019","journal-title":"Orthop J Sports Med"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1007\/s40273-018-0737-z","article-title":"Autologous Chondrocyte Implantation with Chondrosphere for Treating Articular Cartilage Defects in the Knee: An Evidence Review Group Perspective of a NICE Single Technology Appraisal","volume":"37","author":"X Armoiry","year":"2019","journal-title":"Pharmacoeconomics"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta21060","article-title":"Autologous chondrocyte implantation in the knee: Systematic review and economic evaluation","volume":"21","author":"H Mistry","year":"2017","journal-title":"Health Technol Assess"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.joca.2013.04.010","article-title":"Bone marrow stimulation induces greater chondrogenesis in trochlear vs condylar cartilage defects in skeletally mature rabbits","volume":"21","author":"H Chen","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"299","DOI":"10.22203\/ecm.v025a21","article-title":"Alterations of the subchondral bone in osteochondral repair--translational data and clinical evidence","volume":"25","author":"P Orth","year":"2013","journal-title":"Eur Cell Mater"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2325967120959280","DOI":"10.1177\/2325967120959280","article-title":"Clinical and Radiological Outcomes After Autologous Matrix-Induced Chondrogenesis Versus Microfracture of the Knee: A Systematic Review and Meta-analysis With a Minimum 2-Year\n          Follow-up","volume":"8","author":"JH Kim","year":"2020","journal-title":"Orthop J Sports Med"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/1947603519870846","article-title":"Systematic Review and Meta-Analysis of the Clinical Evidence on the Use of Autologous Matrix-Induced Chondrogenesis in the Knee","author":"MR Steinwachs","year":"2019","journal-title":"Cartilage"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1007\/s00264-016-3391-0","article-title":"A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years","volume":"41","author":"M Volz","year":"2017","journal-title":"Int Orthop"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"2325967119868212","DOI":"10.1177\/2325967119868212","article-title":"Collagen-Covered Autologous Chondrocyte Implantation Versus Autologous Matrix-Induced Chondrogenesis: A Randomized Trial Comparing 2 Methods for Repair of Cartilage Defects of the\n          Knee","volume":"7","author":"V Fossum","year":"2019","journal-title":"Orthop J Sports Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1177\/0363546509357915","article-title":"Autologous chondrocyte implantation: A long-term follow-up","volume":"38","author":"L Peterson","year":"2010","journal-title":"Am J Sports Med"},{"issue":"S 01","key":"ref23","doi-asserted-by":"publisher","first-page":"167S","DOI":"10.1177\/0363546509351650","article-title":"Return to Sports Participation after Articular Cartilage Repair in the Knee: Scientific Evidence","volume":"37","author":"K Mithoefer","year":"2009","journal-title":"Am J Sports Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1302\/0301-620X.94B4.27495","article-title":"Minimum ten-year results of a prospective randomised study of autologous chondrocyte implantation versus mosaicplasty for symptomatic articular cartilage lesions of the knee","volume":"94","author":"G Bentley","year":"2012","journal-title":"J Bone Joint Surg Br"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/JSA.0b013e31818e0e4a","article-title":"Minced Articular Cartilage\u2014Basic Science, Surgical Technique, and Clinical Application","volume":"16","author":"F McCormick","year":"2008","journal-title":"Sports Med Arthrosc Rev"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e97","DOI":"10.1016\/j.eats.2020.09.015","article-title":"Arthroscopic Minced Cartilage Implantation (MCI): A Technical Note","volume":"10","author":"S Schneider","year":"2020","journal-title":"Arthrosc Tech"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2325967119853773","DOI":"10.1177\/2325967119853773","article-title":"One-Step Autologous Minced Cartilage Procedure for the Treatment of Knee Joint Chondral and Osteochondral Lesions: A Series of 27 Patients With 2-Year Follow-up","volume":"7","author":"FK Massen","year":"2019","journal-title":"Orthop J Sports Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1080\/03008200802325037","article-title":"Equal Cartilage Repair Response Between Autologous Chondrocytes in a Collagen Scaffold and Minced Cartilage Under a Collagen Scaffold: An in Vivo Study in Goats","volume":"49","author":"M Lind","year":"2008","journal-title":"Connect Tissue Res"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-018-5242-6","article-title":"Bone block augmentation from the iliac crest for treatment of deep osteochondral defects of the knee resembles biomechanical properties of the subchondral bone. Knee Surgery, Sports\n          Traumatology","author":"S Grechenig","year":"2018","journal-title":"Arthroscopy"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.arthro.2012.12.002","article-title":"Outcomes of osteochondral allograft transplantation in the knee","volume":"29","author":"J Chahal","year":"2013","journal-title":"Arthroscopy"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00402-012-1637-x","article-title":"A non-randomized controlled clinical trial on autologous chondrocyte implantation (ACI) in cartilage defects of the medial femoral condyle with or without high tibial osteotomy in patients\n          with varus deformity of less than 5\u00b0","volume":"133","author":"G Bode","year":"2013","journal-title":"Arch Orthop Trauma Surg"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1007\/s00402-020-03476-6","article-title":"Decision making for concomitant high tibial osteotomy (HTO) in cartilage repair patients based on a nationwide cohort study of 4968 patients","volume":"140","author":"S Faber","year":"2020","journal-title":"Arch Orthop Trauma Surg"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1177\/1947603520982347","article-title":"Comparison of Clinical Outcome following Cartilage Repair for Patients with Underlying Varus Deformity with or without Additional High Tibial Osteotomy: A Propensity Score\u2013Matched Study\n          Based on the German Cartilage Registry (KnorpelRegister DGOU)","author":"S Faber","year":"2020","journal-title":"Cartilage"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s00402-016-2432-x","article-title":"Characteristics and associated factors of Klee cartilage lesions: preliminary baseline-data of more than 1000 patients from the German cartilage registry (KnorpelRegister DGOU)","volume":"136","author":"G Spahn","year":"2016","journal-title":"Arch Orthop Trauma Surg"}],"container-title":["Zeitschrift f\u00fcr Orthop\u00e4die und Unfallchirurgie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1663-6807.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T19:54:36Z","timestamp":1676577276000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1663-6807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,21]]},"references-count":34,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,2,16]]},"published-print":{"date-parts":[[2023,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1663-6807","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1864-6697","1864-6743"],"issn-type":[{"value":"1864-6697","type":"print"},{"value":"1864-6743","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,21]]}}}