{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T17:10:16Z","timestamp":1725988216950},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n          Klinik und Therapie\u2002Neben den gut bekannten klinischen Symptomen der Hantavirus-Erkrankung (Fieber, Flanken- und abdominelle Schmerzen sowie Arthralgien) geraten zunehmend auch ungew\u00f6hnliche neurologische Ver\u00e4nderungen im Rahmen der Infektion in den Fokus. Das Spektrum reicht von passageren Myopien bis zu schweren Paresen im Rahmen eines Guillain-Barr\u00e9-Syndroms. In Endemiegebieten sind Schnellteste auf IgM-Antik\u00f6rper zur Ersteinsch\u00e4tzung eine differenzialdiagnostische Hilfe. Therapeutisch stehen weiterhin nur supportive Ma\u00dfnahmen bis zur passageren Dialyse zur Verf\u00fcgung.<\/jats:p><jats:p>\n          Ausbruchsregionen in Deutschland und regionale Unterscheidung der Virusst\u00e4mme\u2002Durch molekulargenetische Analyse und Vergleich von Hantavirus-St\u00e4mmen aus Patienten und M\u00e4usen desselben geografischen Gebietes konnten Viren verschiedener Ausbruchsregionen charakterisiert werden. Inzwischen sind die Puumalaviren der Haupt-Ausbruchsregionen in Deutschland molekular so gut charakterisiert, dass anhand der Nukleotidsequenz des im Patienten nachgewiesenen Virusstammes R\u00fcckschl\u00fcsse auf die Gegend m\u00f6glich sind, in der die Infektion des Patienten stattgefunden hat.<\/jats:p><jats:p>\n          Nachweis weiterer pathogener Hantaviren in Deutschland\u2002Die bislang nachgewiesenen humanpathogenen Hantaviren in Deutschland sind das Puumalavirus (Reservoir: R\u00f6telmaus) und das Dobrava-Belgrad-Virus, Genotyp Kurkino (Reservoir: Brandmaus). K\u00fcrzlich gelang der molekulare Nachweis von weiteren Hantaviren in Patienten mit entsprechender klinischer Symptomatik. Man kann davon ausgehen, dass auch das Seoulvirus (Reservoir: Ratten) und das Tulavirus (Reservoir: Feldmaus und verwandte Arten) in Deutschland vereinzelt Hantavirus-Erkrankungen ausl\u00f6sen.<\/jats:p><jats:p>\n          Viruseintritt auch \u00fcber den Darm?\u2002Neue Ergebnisse lassen es m\u00f6glich erscheinen, dass die Infektion des Menschen nicht nur auf dem \u00fcblichen Weg der Einatmung virushaltiger Aerosole erfolgen kann, sondern auch durch Ingestion virushaltigen Materials.<\/jats:p><jats:p>\n          Zur Frage der Mensch-zu-Mensch-\u00dcbertragung von Hantaviren\u2002Bei Patienten mit Hantavirus-Infektion bzw. -Erkrankung kann davon ausgegangen werden, dass diese f\u00fcr ihre Umwelt nicht infekti\u00f6s sind. Ein neues systematisches Review konnte auch die zuvor in Einzelf\u00e4llen f\u00fcr s\u00fcdamerikanische Hantaviren postulierte Mensch-zu-Mensch-\u00dcbertragung nicht best\u00e4tigen.<\/jats:p><jats:p>\n          Neue Hantaviren in neuen Wirten\u2002W\u00e4hrend alle bekannten humanpathogenen Hantaviren von Nagetieren \u00fcbertragen werden, wurden in den letzten Jahren weitere Hantaviren in Spitzm\u00e4usen, Maulw\u00fcrfen und Flederm\u00e4usen nachgewiesen. Die klinische Bedeutung dieser neuen Viren ist noch weitgehend unbekannt.<\/jats:p>","DOI":"10.1055\/a-1664-7259","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T23:42:17Z","timestamp":1647387737000},"page":"312-318","source":"Crossref","is-referenced-by-count":4,"title":["Hantavirus-Erkrankungen: Ein Update"],"prefix":"10.1055","volume":"147","author":[{"given":"J\u00f6rg","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Helmut-Ruska-Haus, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, 10117 Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Loyen","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin, Nephrologie und Dialyse, Herz-Jesu-Krankenhaus, M\u00fcnster-Hiltrup"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirko","family":"Faber","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Infektionsepidemiologie, Robert Koch-Institut, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlev H.","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Virologie, Helmut-Ruska-Haus, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, 10117 Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"ref1","first-page":"461","article-title":"Hantaviruses as zoonotic pathogens in Germany","volume":"110","author":"D H Kr\u00fcger","year":"2013","journal-title":"Dtsch Arztebl Int"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1055\/s-0034-1370207","article-title":"Bedrohung durch zoonotische Viren: Neues zur Hantavirus-Erkrankung","volume":"139","author":"D H Kr\u00fcger","year":"2014","journal-title":"Dtsch Med 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002","article-title":"Auf Hirn und Nieren \u2013 Neurologische Manifestationen der Hantavirus-Infektion","author":"M Loyen","year":"2019","journal-title":"11.\u00a0Jahrestagung der Deutschen Gesellschaft f\u00fcr Nephrologie"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1179\/0001551214Z.00000000085","article-title":"Guillain-Barr\u00e9 syndrome associated with Puumala hantavirus infection","volume":"69","author":"G Tassart","year":"2014","journal-title":"Acta Clinica Belgica"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/cid\/cit394","article-title":"High-dose intravenous methylprednisolone for hantavirus cardiopulmonary syndrome in Chile: a double-blind, randomized controlled clinical trial","volume":"57","author":"P A Vial","year":"2013","journal-title":"Clin Infect Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"610","DOI":"10.3390\/v11070610","article-title":"Progress on the prevention and treatment of 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