{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:43:29Z","timestamp":1700700209406},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>Definition und Inzidenz\u2002Monoklonale Gammopathien sind h\u00e4ufig, haben jedoch nicht immer eine klinische Bedeutung.<\/jats:p><jats:p>Diagnose\u2002Sie wird \u00fcber Serumelektrophorese, Immunfixation und Bestimmung der freien Leichtketten gestellt. F\u00fcr die Aufarbeitung eines auszuschlie\u00dfenden multiplen Myeloms gibt es konkrete, risikoadaptierte Empfehlungen. Die weitere Diagnostik besteht dann aus einer Knochenmarkpunktion, einer Untersuchung des 24h-Sammelurins und einer Ganzk\u00f6rper-Bildgebung. Zum Ausschluss auch kleiner Osteolysen sollte anstatt der historischen R\u00f6ntgenaufnahmen nach \u201ePariser Schema\u201c eine CT ohne Kontrastmittel durchgef\u00fchrt werden. Mit der MRT gelingt der Nachweis fokaler L\u00e4sionen im Knochenmark.<\/jats:p><jats:p>Verlaufskontrollen und Prognose\u2002Eine MGUS-Verlaufskontrolle sollte nach individuellem Risiko geplant werden. Dennoch weisen Personen mit MGUS eine erh\u00f6hte Morbidit\u00e4t auf. Man findet hier h\u00e4ufiger Osteoporosen und ein erh\u00f6htes Infektionsrisiko.<\/jats:p><jats:p>MGUS-assoziierte Erkrankungen\u2002In den meisten F\u00e4llen gen\u00fcgen f\u00fcr die weitere Abkl\u00e4rung eine gr\u00fcndliche Anamnese und k\u00f6rperliche Untersuchung.<\/jats:p>","DOI":"10.1055\/a-1664-7353","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T22:32:13Z","timestamp":1653949933000},"page":"675-682","source":"Crossref","is-referenced-by-count":0,"title":["Die monoklonale Gammopathie (un)klarer Signifikanz"],"prefix":"10.1055","volume":"147","author":[{"given":"Maximilian","family":"Steinhardt","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kort\u00fcm","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Einsele","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Rasche","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik II, Universit\u00e4tsklinikum W\u00fcrzburg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/S0025-6196(11)61090-2","article-title":"Prevalence of monoclonal gammopathy of undetermined significance: study of 52802 persons in Nagasaki City, Japan","volume":"82","author":"M Iwanaga","year":"2007","journal-title":"Mayo Clin Proc"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/S0025-6196(11)61089-6","article-title":"Prevalence of monoclonal gammopathy of undetermined significance among men in Ghana","volume":"82","author":"O Landgren","year":"2007","journal-title":"Mayo Clin Proc"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41408-021-00480-w","article-title":"Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies","volume":"11","author":"S R\u00f6gnvaldsson","year":"2021","journal-title":"Blood Cancer J"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1182\/blood-2008-12-192575","article-title":"Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance","volume":"114","author":"C M Vachon","year":"2009","journal-title":"Blood"},{"key":"ref5","first-page":"211","article-title":"Studies on conditions associated with disturbed gamma globulin formation (gammopathies)","volume":"56","author":"J Waldenstrom","year":"1960","journal-title":"Harvey Lect"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/0002-9343(78)90522-3","article-title":"Monoclonal gammopathy of undetermined significance. 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