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There is a discrepancy between the incidence of Pr-AKI in developing and in developed countries, with the former experiencing a decrease and the latter an\n\t\t\t\t\tincrease in Pr-AKI in recent decades. Whereas septic and hemorrhagic complications predominated in the past, nowadays hypertensive disorders and thrombotic microangiopathy are the leading\n\t\t\t\t\tcauses of Pr-AKI. Modern lifestyles and the availability and widespread use of in-vitro fertilization techniques in industrialized countries have allowed more women of advanced age to become\n\t\t\t\t\tpregnant. This has led to a rise in the percentage of high-risk pregnancies due to the disorders and comorbidities inherent to or accompanying aging, such as diabetes, arterial hypertension\n\t\t\t\t\tand preexisting chronic kidney disease. Last but not least, the heterogeneity of symptoms, the often overlapping clinical and laboratory characteristics and the pathophysiological changes\n\t\t\t\t\trelated to pregnancy make the diagnosis and management of Pr-AKI a difficult and challenging task for the treating physician. In addition to general supportive management strategies such as\n\t\t\t\t\tvolume substitution, blood pressure control, prevention of seizures or immediate delivery, each disease entity requires a specific therapy to reduce maternal and fetal complications. In this\n\t\t\t\t\treview, we used the current literature to provide a summary of the physiologic and pathophysiologic changes in renal physiology which occur during pregnancy. In the second part, we present\n\t\t\t\t\tcommon and rare disorders which lead to Pr-AKI and provide an overview of the available treatment options.<\/jats:p>","DOI":"10.1055\/a-1666-0483","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T23:38:21Z","timestamp":1646350701000},"page":"297-316","source":"Crossref","is-referenced-by-count":7,"title":["Pr-AKI: Acute Kidney Injury in Pregnancy \u2013 Etiology, Diagnostic Workup, Management"],"prefix":"10.1055","volume":"82","author":[{"given":"Florian G.","family":"Scurt","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Nieren- und Hochdruckerkrankungen, Diabetologie und Endokrinologie, Medizinische Fakult\u00e4t der Otto-von-Guericke-Universit\u00e4t, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"Morgenroth","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Nieren- und Hochdruckerkrankungen, Diabetologie und Endokrinologie, Medizinische Fakult\u00e4t der Otto-von-Guericke-Universit\u00e4t, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Bose","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Gastroenterologie, Hepatologie und Infektiologie, Medizinische Fakult\u00e4t der Otto-von-Guericke-Universit\u00e4t, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Mertens","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Nieren- und Hochdruckerkrankungen, Diabetologie und Endokrinologie, Medizinische Fakult\u00e4t der Otto-von-Guericke-Universit\u00e4t, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Chatzikyrkou","sequence":"additional","affiliation":[{"name":"PHV-Dialysezentrum, Halberstadt, Germany"},{"name":"Klinik f\u00fcr Nephrologie, Medizinische Hochschule Hannover, Hannover, 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