{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T07:39:09Z","timestamp":1764056349660,"version":"3.45.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"the project of the Health and Family Planning Commission of Jiangxi Province","award":["20195082"],"award-info":[{"award-number":["20195082"]}]},{"name":"the Jiangxi Educational Committee foundation","award":["GJJ170006"],"award-info":[{"award-number":["GJJ170006"]}]},{"name":"the project of the Jiangxi Department of Science and Technology","award":["20202BBGL73109"],"award-info":[{"award-number":["20202BBGL73109"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Meningeal carcinomatosis (MC) is reported to occur in 4%\u201315% of patients with solid tumors. MC is not commonly associated with gastric carcinoma and is extremely rare in patients with early gastric cancer (EGC). MC derived from EGC after curative endoscopic submucosal dissection (ESD) has not been reported before. We present a rare case of a 49-year-old patient who developed MC after curative ESD of EGC. The cancer was an ulcerated lesion approximately 1.0 cm in diameter in endoscopic appearance in the minor curvature of the gastric antrum. The pathological examination after ESD indicated high-grade intraepithelial neoplasia (1.3 \u00d7 2.1 cm in size) with localized moderately differentiated adenocarcinoma (0\u2013IIc in tumor stage, intestinal type in Lauren classification), which was confined to the mucosal layer with an intact submucosal layer and muscularis propria. The lesion was removed entirely by curative dissection without vertical and horizontal resection margins involvement in pathology. Two months after ESD, the patient was readmitted for severe headache and vomiting. Cytological examination of the cerebrospinal fluid found malignant tumor cells, which were considered by pathologists to have metastasized from the stomach, further confirming MC derived from EGC. The patient\u2019s condition deteriorated dramatically, which prevented him from receiving further therapies, such as chemotherapy, and he died 3 days after the diagnosis of MC. In conclusion, EGC can cause MC, even after curative ESD. New neurological manifestations in patients with EGC can alert physicians to a diagnosis of MC, and more attention needs to be paid to evaluating the nervous system and establishing diagnostic and therapeutic strategies as soon as possible.<\/jats:p>","DOI":"10.1055\/a-1668-0625","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T20:42:47Z","timestamp":1637786567000},"page":"593-597","source":"Crossref","is-referenced-by-count":0,"title":["Meningeal carcinomatosis following a curative endoscopic submucosal dissection of early gastric cancer: a case report"],"prefix":"10.1055","volume":"60","author":[{"given":"Zhengping","family":"Yu","sequence":"first","affiliation":[{"name":"Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Tu","sequence":"first","affiliation":[{"name":"Neurology, First Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenwen","family":"Wang","sequence":"first","affiliation":[{"name":"Gastroenterology, Gaoxin Hospital of the First Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Ding","sequence":"first","affiliation":[{"name":"Medical Cosmetology, Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueping","family":"Yang","sequence":"first","affiliation":[{"name":"Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"J Ferlay","year":"2019","journal-title":"Int J Cancer"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"5975","DOI":"10.7150\/jca.35527","article-title":"Long-term results of conversion therapy for initially unresectable gastric cancer: analysis of 122 patients at the National Cancer Center in China","volume":"10","author":"T Wang","year":"2019","journal-title":"J Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10120-011-0041-5","article-title":"Japanese classification of gastric carcinoma: 3rd English edition","volume":"14","author":"Japanese Gastric Cancer Association","year":"2011","journal-title":"Gastric Cancer"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"5672","DOI":"10.3748\/wjg.v20.i19.5672","article-title":"Treatment of early gastric cancer in the Western World","volume":"20","author":"E Bollschweiler","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s40792-018-0479-3","article-title":"Successful treatment of liver metastases arising from early gastric cancer achieved clinical complete response by nivolumab","volume":"4","author":"T Namikawa","year":"2018","journal-title":"Surg Case Rep"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"5016","DOI":"10.3748\/wjg.v19.i30.5016","article-title":"Bone metastasis from early gastric cancer following non-curative endoscopic submucosal dissection","volume":"19","author":"H Kawabata","year":"2013","journal-title":"World J Gastroenterol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"52307","DOI":"10.18632\/oncotarget.10740","article-title":"Metastatic spread in patients with gastric cancer","volume":"7","author":"M Riihim\u00e4ki","year":"2016","journal-title":"Oncotarget"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s10120-016-0664-7","article-title":"Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a multicenter collaborative study","volume":"20","author":"S Tanabe","year":"2017","journal-title":"Gastric Cancer"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.5009\/gnl17095","article-title":"Long-term outcomes of using endoscopic submucosal dissection to treat early gastric cancer","volume":"12","author":"T Nishizawa","year":"2018","journal-title":"Gut Liver"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/den.12518","article-title":"Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer","volume":"28","author":"H Ono","year":"2016","journal-title":"Dig Endosc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2169\/internalmedicine.55.5129","article-title":"Efficacy of intrathecal MTX\/Ara-C combined with systemic chemotherapy in a gastric cancer patient with meningeal carcinomatosis","volume":"55","author":"T Yamasaki","year":"2016","journal-title":"Intern Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1177\/107327481702400104","article-title":"Neoplastic meningitis","volume":"12","author":"MC Chamberlain","year":"2006","journal-title":"The Neurologist"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1023\/b:neon.0000013462.43156.f4","article-title":"Leptomeningeal carcinomatosis in gastric cancer","volume":"66","author":"JL Lee","year":"2004","journal-title":"J Neurooncol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/jso.20018","article-title":"Application of minimally invasive treatment for early gastric cancer","volume":"85","author":"WJ Hyung","year":"2004","journal-title":"J Surg Oncol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.nic.2016.06.008","article-title":"Metastasis in adult brain tumors","volume":"26","author":"Jr Barajas","year":"2016","journal-title":"Neuroimaging Clin N Am"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1093\/jjco\/hyi076","article-title":"CD10-positive stromal cells in gastric carcinoma: correlation with invasion and metastasis","volume":"35","author":"WB Huang","year":"2005","journal-title":"Jpn J Clin Oncol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/B978-0-12-811161-1.00013-X","article-title":"Leptomeningeal metastasis","volume":"149","author":"S Taillibert","year":"2018","journal-title":"Handb Clin Neurol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"iv285","DOI":"10.1093\/annonc\/mdh941","article-title":"The diagnostic and therapeutic management of leptomeningeal carcinomatosis","volume":"15","author":"N Pavlidis","year":"2004","journal-title":"Ann Oncol"},{"key":"ref19","first-page":"34","article-title":"Leptomeningeal carcinomatosis in solid tumors: clinical manifestation and treatment","volume":"33","author":"JO Park","year":"2001","journal-title":"Journal of the Korean Cancer Association"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S1470-2045(10)70034-6","article-title":"Intrathecal chemotherapy for treatment of leptomeningeal dissemination of metastatic tumours","volume":"11","author":"P Beauchesne","year":"2010","journal-title":"Lancet Oncol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/cncr.30911","article-title":"Leptomeningeal metastasis from systemic cancer: Review and update on management","volume":"124","author":"N Wang","year":"2018","journal-title":"Cancer"}],"container-title":["Zeitschrift f\u00fcr Gastroenterologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1668-0625.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T07:37:08Z","timestamp":1764056228000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1668-0625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":21,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,3,29]]},"published-print":{"date-parts":[[2022,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1668-0625","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0044-2771","1439-7803"],"issn-type":[{"type":"print","value":"0044-2771"},{"type":"electronic","value":"1439-7803"}],"subject":[],"published":{"date-parts":[[2021,11,24]]}}}