{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:23:06Z","timestamp":1792088586737,"version":"4.4.0"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gesundheitswesen"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Ziel der Studie Die alveol\u00e4re Echinokokkose (AE) ist eine seltene Parasitose verursacht durch den Erreger Echinococcus multilocularis. In vielen L\u00e4ndern wird ein Anstieg der Fallzahlen beobachtet. Ziel der Arbeit ist die Untersuchung der aktuellen Pr\u00e4valenz und der Ver\u00e4nderung des geographische Verteilungsmusters.<\/jats:p><jats:p>Methodik Die Datenerhebung erfolgte retrospektiv f\u00fcr den Zeitraum 1992\u20132018 anhand der registrierten F\u00e4lle im nationalen Erkrankungsregistern f\u00fcr die AE in Deutschland. Die statistische Analyse erfolgte mittels dem statistischen Auswertungssystem SAS Version 9.4 (SAS Institute, Cary, N.C., USA).<\/jats:p><jats:p>Ergebnisse Das Untersuchungskollektiv von n=569 Patienten umfasste n=322 (56,59%) Frauen und n=247 (43,40%) M\u00e4nner. Das mittleres Durchschnittsalter der Patienten mit alveol\u00e4rer Echinokokkose bei Erstvorstellung betrug 53,90\u00b117,54 Jahre (Median: 56,00 Jahre). Die Moran\u2019s I Teststatistik ergab f\u00fcr den Zeitraum 1992\u20132018 eine positive r\u00e4umliche Autokorrelation entsprechend einer heterogenen Verteilung der Erkrankungsf\u00e4lle in Deutschland (I=0,4165; Z=10,9591, p=0,001). F\u00fcr den gesamten Untersuchungszeitraum (1992\u20132018) konnte ein Anstieg der alters- und geschlechtsspezifischen Pr\u00e4valenz ermittelt werden. Die Gesamtpr\u00e4valenz im Zeitraum 1992\u20132018 lag bei 0,71 Erkrankungsf\u00e4lle pro 100\u2009000 Einwohner. Die Ermittlung der Pr\u00e4valenz f\u00fcr den Zeitraum 1992\u20132018 ergab f\u00fcr M\u00e4nnern 0,31 F\u00e4lle, f\u00fcr Frauen 0,40 F\u00e4lle pro 100\u2009000 Einwohner. Im Zeitraum von 1992\u20131996 waren in 11\/16 (68,8%) Bundesl\u00e4ndern (Berlin, Brandenburg, Bremen, Hamburg, Mecklenburg-Vorpommern, Rheinland-Pfalz, Saarland, Sachsen, Sachsen-Anhalt, Schleswig-Holstein und Th\u00fcringen) noch keine AE-F\u00e4lle registriert worden. Die Auswertung zeigt j\u00fcngst ein vermehrtes vorkommen von F\u00e4llen in den Bundesl\u00e4ndern Hessen, Rheinland-Pfalz und Nordrhein-Westfalen.<\/jats:p><jats:p>Schlussfolgerungen Die Analyse zeigt einen Anstieg der Pr\u00e4valenz sowie zunehmend vermehrt Erkrankungsf\u00e4lle au\u00dferhalb der klassischen Hauptendemiegebiete Baden-W\u00fcrttemberg und Bayern.<\/jats:p>","DOI":"10.1055\/a-1670-7485","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:12:22Z","timestamp":1638835942000},"page":"258-265","source":"Crossref","is-referenced-by-count":5,"title":["Untersuchung zur Ausbreitung und Entwicklung der alveol\u00e4ren Echinokokkose in Deutschland, 1992\u20132018"],"prefix":"10.1055","volume":"85","author":[{"given":"Isabelle","family":"Kwiedor","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinikum Ulm, Ulm, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Kratzer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinikum Ulm, Ulm, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Schlingeloff","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinikum Ulm, Ulm, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Schmidberger","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinikum Ulm, Ulm, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"ref1","first-page":"1","volume-title":"WHO-OIE Manual on Echinococcosis in Humans and Animals: a Public Health Problem of Global Concern","author":"J 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