{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:33:16Z","timestamp":1785529996245,"version":"3.56.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n            Objective\u2003Spontaneous intestinal perforation (SIP) occurs commonly in extremely low gestational age newborns (ELGANs; &lt;30 weeks' GA). Early, concurrent neonatal use of indomethacin (Neo_IN) and hydrocortisone (Neo_HC) is a known risk for SIP. Mothers in premature labor often receive indomethacin (Mat_IN) for tocolysis and steroids (Mat_S) for fetal maturation. Coincidentally, ELGANs may receive Neo_IN or Neo_HC within the first week of life. There are limited data on the effect of combined exposures to maternal and neonatal medications. We hypothesized that proximity exposure to these medications may increase the risk of SIP.<\/jats:p><jats:p>\n            Study Design\u2003We reviewed the medical records of ELGANs from June 2014 to December 2019 at a single level III neonatal intensive care unit. We compared antenatal and postnatal indomethacin and steroid use between neonates with and without SIP. For analysis, chi-square, Student's t-test, Fisher's exact test, and Mann\u2013Whitney U tests were used.<\/jats:p><jats:p>\n            Results\u2003Among 417 ELGANs, SIP was diagnosed in 23, predominantly in neonates\u2009&lt;\u200926 weeks' GA (n\u2009=\u200921\/126, 16.7%). Risk factors analysis focused on this GA cohort in which SIP was most prevalent. Mat_IN administration within 2 days of delivery increased SIP risk (odds ratio: 3; 95% confidence interval: 1.25\u20137.94; p\u2009=\u20090.036). Neo_HC was not independently associated with SIP (p\u2009=\u20090.38). A higher proportion of SIP group had close temporal exposure of Mat_IN and Neo_HC compared with the non-SIP group, though not statistically significant (14 vs. 7%, p\u2009=\u20090.24).<\/jats:p><jats:p>\n            Conclusion\u2003Peripartum Mat_IN was associated with increased risk for SIP in this small study sample. Larger studies are needed to further delineate SIP risk from the interaction of peripartum maternal medication with early postnatal therapies and disease pathophysiology.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1673-0183","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:48:47Z","timestamp":1634690927000},"page":"174-179","source":"Crossref","is-referenced-by-count":6,"title":["Association of Intrapartum Drugs with Spontaneous Intestinal Perforation: A Single-Center Retrospective Review"],"prefix":"10.1055","volume":"41","author":[{"given":"Ashley","family":"Mantle","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Utah Health, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of Utah Health, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Judkins","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of Utah Health, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwa","family":"Chanthavong","sequence":"additional","affiliation":[{"name":"Division of Decision Support, University of Utah Health, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Yoder","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of Utah Health, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of Utah Health, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,11,28]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.jpedsurg.2013.11.051","article-title":"Mortality associated with laparotomy-confirmed neonatal spontaneous intestinal perforation: a prospective 5-year multicenter analysis","volume":"49","author":"J G Fisher","year":"2014","journal-title":"J Pediatr Surg"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3233\/NPM-16148","article-title":"Intestinal perforation in the premature infant","volume":"10","author":"K Vongbhavit","year":"2017","journal-title":"J Neonatal Perinatal Med"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"F504","DOI":"10.1136\/archdischild-2016-312195","article-title":"Emergency laparotomy in infants born at <26 weeks gestation: a neonatal network-based cohort study of frequency, 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