{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:48:38Z","timestamp":1765828118903},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>\n            Objective\u2003While administration of antenatal corticosteroids prior to term elective cesarean deliveries has been shown in international randomized controlled trials to decrease the rates of respiratory distress syndrome and transient tachypnea of the newborn, this is not a standard practice in the United States. We aim to determine if the administration of antenatal corticosteroids for fetal lung maturation within 1 week of scheduled early term cesarean delivery resulted in decreased composite respiratory morbidity.<\/jats:p><jats:p>\n            Study Design\u2003Historical cohort study including women who underwent scheduled early term cesarean delivery of a singleton, non-anomalous neonate at Mount Sinai Hospital between May 2015 and August 2019, comparing those who completed a course of antenatal corticosteroids within 1 week of delivery to those who did not. The primary outcome was composite respiratory morbidity defined as respiratory distress syndrome, transient tachypnea of the newborn, and neonatal intensive care unit admission for respiratory morbidity. Maternal and neonatal characteristics were compared between groups using t-tests or Wilcoxon-Rank Sum tests for continuous measures and Chi-square or Fisher's exact tests for categorical measures, as appropriate. The outcomes were assessed using logistic regression.<\/jats:p><jats:p>\n            Results\u2003History of preterm birth was significantly higher in those who received antenatal corticosteroids compared with those who did not (24.0 vs. 10.9%, p\u2009=\u20090.01). Neonates who were not exposed to antenatal corticosteroids were more likely to experience the composite respiratory morbidity compared with those who were exposed (RR 4.1, 95% CI 1.2\u201313.7; p\u2009=\u20090.02). Between 37 and 38 weeks, neonates who did not receive steroids were at increased risk of composite respiratory morbidity (RR 11.7, 95% CI 1.5\u201389.0, p\u2009&lt;\u20090.01), however, there was no difference for those born between 38 and 39 weeks.<\/jats:p><jats:p>\n            Conclusion\u2003Betamethasone course administered prior to planned early term cesarean delivery was associated with a statistically significant reduction in the neonatal composite respiratory morbidity compared with routine management.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1674-6198","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T22:54:04Z","timestamp":1634770444000},"page":"0915-0920","source":"Crossref","is-referenced-by-count":3,"title":["Antenatal Corticosteroids Decrease the Risk of Composite Neonatal Respiratory Morbidity in Planned Early Term Cesarean Deliveries"],"prefix":"10.1055","volume":"39","author":[{"given":"Chelsea A.","family":"DeBolt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai Health System and Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaelyn","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai Health System and Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krupa","family":"Harishankar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai Health System and Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Monro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai Health System and Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elianna","family":"Kaplowitz","sequence":"additional","affiliation":[{"name":"Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Bianco","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai Health System and Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai Health System and Icahn School of Medicine at Mount Sinai, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1471-0528.1995.tb09060.x","article-title":"Neonatal respiratory morbidity and mode of delivery at term: influence of timing of elective caesarean section","volume":"102","author":"J J Morrison","year":"1995","journal-title":"Br J Obstet Gynaecol"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1001\/jama.1995.03520290065031","article-title":"Effect of corticosteroids for fetal maturation on perinatal outcomes","volume":"273","author":"NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes","year":"1995","journal-title":"JAMA"},{"issue":"14","key":"ref3","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1056\/NEJMoa1516783","article-title":"Antenatal betamethasone for women at risk for late preterm delivery","volume":"374","author":"C Gyamfi-Bannerman","year":"2016","journal-title":"N Engl J Med"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1053\/j.semperi.2006.07.011","article-title":"Respiratory transition in infants delivered by cesarean section","volume":"30","author":"L Jain","year":"2006","journal-title":"Semin Perinatol"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1651-2227.2004.tb02990.x","article-title":"Neonatal respiratory morbidity risk and mode of delivery at term: influence of timing of elective caesarean delivery","volume":"93","author":"V Zanardo","year":"2004","journal-title":"Acta Paediatr"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1524-475X.2004.04060.x","article-title":"Caesarean section. Clinical Guideline. National Collaborating Centre for Women's and Children's Health: commissioned by the National Institute for Clinical Excellence","volume":"1","author":"D Bick","year":"2004","journal-title":"Worldviews Evid Based Nurs"},{"issue":"08","key":"ref8","first-page":"CD006614","article-title":"Corticosteroids for preventing neonatal respiratory morbidity after elective caesarean section at term","volume":"8","author":"A Sotiriadis","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1136\/bmj.38547.416493.06","article-title":"Antenatal betamethasone and incidence of neonatal respiratory distress after elective caesarean section: pragmatic randomised trial","volume":"331","author":"P Stutchfield","year":"2005","journal-title":"BMJ"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.3109\/14767058.2014.958461","article-title":"Antenatal steroids at 37 weeks, does it reduce neonatal respiratory morbidity? A randomized trial","volume":"28","author":"M R Ahmed","year":"2015","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ejogrb.2016.01.026","article-title":"Antenatal corticosteroid administration before elective caesarean section at term to prevent neonatal respiratory morbidity: a randomized controlled trial","volume":"199","author":"A M Nada","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1080\/14767058.2017.1293026","article-title":"Does implementing a regime of dexamethasone before planned cesarean section at term reduce admission with respiratory morbidity to neonatal intensive care unit? A randomized controlled trial","volume":"31","author":"A M Nooh","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/(SICI)1099-0496(199704)23:4<287::AID-PPUL6>3.0.CO;2-J","article-title":"Prediction of surfactant dysfunction in term infants by the click test","volume":"23","author":"T Bhuta","year":"1997","journal-title":"Pediatr Pulmonol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1136\/bmj.288.6431.1635","article-title":"Non-specificity of surfactant deficiency in neonatal respiratory disorders","volume":"288","author":"D K James","year":"1984","journal-title":"Br Med J (Clin Res Ed)"},{"issue":"05","key":"ref15","first-page":"345","article-title":"Immature epithelial Na+ channel expression is one of the pathogenetic mechanisms leading to human neonatal respiratory distress syndrome","volume":"108","author":"H M O'Brodovich","year":"1996","journal-title":"Proc Assoc Am Physicians"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1674-6198.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T08:20:51Z","timestamp":1660119651000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1674-6198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,20]]},"references-count":14,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2022,7,26]]},"published-print":{"date-parts":[[2022,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1674-6198","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10,20]]},"published":{"date-parts":[[2021,10,20]]}}}