{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:37:38Z","timestamp":1788514658881,"version":"build-2803163510"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD21410"],"award-info":[{"award-number":["HD21410"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD27860"],"award-info":[{"award-number":["HD27860"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD27869"],"award-info":[{"award-number":["HD27869"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD27915"],"award-info":[{"award-number":["HD27915"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD27917"],"award-info":[{"award-number":["HD27917"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD34116"],"award-info":[{"award-number":["HD34116"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD34136"],"award-info":[{"award-number":["HD34136"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD34208"],"award-info":[{"award-number":["HD34208"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD40485"],"award-info":[{"award-number":["HD40485"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD40500"],"award-info":[{"award-number":["HD40500"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD40512"],"award-info":[{"award-number":["HD40512"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD40544"],"award-info":[{"award-number":["HD40544"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["M01 RR00080"],"award-info":[{"award-number":["M01 RR00080"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD40545"],"award-info":[{"award-number":["HD40545"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD40560"],"award-info":[{"award-number":["HD40560"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["U01 HD36801"],"award-info":[{"award-number":["U01 HD36801"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n            Objective\u2003The fetal consequences of intrapartum fetal tachycardia with maternal fever or clinical chorioamnionitis are not well studied. We evaluated the association between perinatal morbidity and fetal tachycardia in the setting of intrapartum fever.<\/jats:p><jats:p>\n            Study Design\u2003Secondary analysis of a multicenter randomized control trial that enrolled 5,341 healthy laboring nulliparous women \u226536 weeks' gestation. Women with intrapartum fever\u2009\u2265\u200938.0\u00b0C (including those meeting criteria for clinical chorioamnionitis) after randomization were included in this analysis. Isolated fetal tachycardia was defined as fetal heart rate (FHR) \u2265160 beats per minute for at least 10\u2009minutes in the absence of other FHR abnormalities. FHR abnormalities other than tachycardia were excluded from the analysis. The primary outcome was a perinatal composite (5-minute Apgar's score \u22643, intubation, chest compressions, or mortality). Secondary outcomes included low arterial cord pH (pH\u2009&lt;\u20097.20), base deficit \u226512, and cesarean delivery.<\/jats:p><jats:p>\n            Results\u2003A total of 986 (18.5%) of women in the trial developed intrapartum fever, and 728 (13.7%) met criteria to be analyzed; of these, 728 women 336 (46.2%) had maternal-fetal medicine (MFM) reviewer-defined fetal tachycardia, and 349 of the 550 (63.5%) women during the final hour of labor had validated software (PeriCALM) defined fetal tachycardia. After adjusting for confounders, isolated fetal tachycardia was not associated with a significant difference in the composite perinatal outcome (adjusted odds ratio [aOR]\u2009=\u20093.15 [0.82\u201312.03]) compared with absence of tachycardia. Fetal tachycardia was associated with higher odds of arterial cord pH &lt;7.2, aOR\u2009=\u20091.48 (1.01\u20132.17) and of infants with a base deficit \u2265 12, aOR\u2009=\u20092.42 (1.02\u20135.77), but no significant difference in the odds of cesarean delivery, aOR\u2009=\u20091.33 (0.97\u20131.82).<\/jats:p><jats:p>\n            Conclusion\u2003Fetal tachycardia in the setting of intrapartum fever or chorioamnionitis is associated with significantly increased fetal acidemia defined as a pH &lt;7.2 and base excess \u226512 but not with a composite perinatal morbidity.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1675-0901","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T22:54:04Z","timestamp":1634770444000},"page":"160-166","source":"Crossref","is-referenced-by-count":5,"title":["Fetal Tachycardia in the Setting of Maternal Intrapartum Fever and Perinatal Morbidity"],"prefix":"10.1055","volume":"41","author":[{"given":"Alan T. N.","family":"Tita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula L.","family":"McGee","sequence":"additional","affiliation":[{"name":"George Washington University Biostatistics Center, Washington, Dist. of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma M.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Bloom","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Varner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Ramin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Texas Health Science Center at Houston-Children's Memorial Herman Hospital Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve N.","family":"Caritis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Peaceman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Sorokin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Sciscione","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Drexel University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall W.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Mercer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, MetroHealth Medical Center- Case Western Reserve University, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Thorp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergal D.","family":"Malone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin","family":"Buhimschi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) 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