{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:25:36Z","timestamp":1782512736339,"version":"3.54.5"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Institute of Allergy and Infectious Disease","award":["R01AI134982"],"award-info":[{"award-number":["R01AI134982"]}]},{"name":"Eunice Kennedy Shriver Institute of Child Health and Human Development","award":["R01HD099250"],"award-info":[{"award-number":["R01HD099250"]}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medicine Sciences","doi-asserted-by":"crossref","award":["R01GM128452"],"award-info":[{"award-number":["R01GM128452"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n            Objective\u2003This study sought to identify concurrent major comorbidities in preterm infants \u226432 weeks of gestation that may have contributed to sepsis-related mortality following a diagnosis of bacteremia or blood culture-negative sepsis within the neonatal period (\u226428 days of life).<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective chart review of infants \u226432 weeks of gestation who were admitted to a single academic network of multiple neonatal intensive care units between January 1, 2012, and December 31, 2015, to determine the primary cause(s) and timing of death in those diagnosed with bacteremia or blood culture-negative sepsis. Direct comparisons between early-onset sepsis (EOS; \u226472\u2009hours) and late-onset sepsis (LOS; &gt;72\u2009hours) were made.<\/jats:p><jats:p>\n            Results\u2003In our study cohort, of 939 total patients with \u226432 weeks of gestation, 182 infants were diagnosed with 198 episodes of sepsis and 7.7% (14\/182) died. Mortality rates did not significantly differ between neonates with bacteremia or blood culture-negative sepsis (7\/14 each group), and those diagnosed with EOS compared with LOS (6\/14 vs. 8\/14). Nearly 80% (11\/14) of infants were transitioned to comfort care prior to their death secondary to a coinciding diagnosis of severe grade-3 or -4 intraventricular hemorrhage, periventricular leukomalacia, necrotizing enterocolitis, and\/or intestinal perforation.<\/jats:p><jats:p>\n            Conclusion\u2003Preexisting comorbidities commonly associated with extreme preterm birth contributed to sepsis-related mortality in our patient cohort.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1675-2899","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T22:52:52Z","timestamp":1634856772000},"page":"134-142","source":"Crossref","is-referenced-by-count":10,"title":["Contribution of Concurrent Comorbidities to Sepsis-Related Mortality in Preterm Infants \u226432 Weeks of Gestation at an Academic Neonatal Intensive Care Network"],"prefix":"10.1055","volume":"41","author":[{"given":"Brian W.","family":"Barnette","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of California, San Diego, College of Medicine, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3099-3387","authenticated-orcid":false,"given":"Benjamin T.","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Department of Public Heath, Herbert Wertheim School of Public Health and Longevity Science, UC San Diego School of Medicine, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Armenta","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, College of Education, Health, and Human Services, California State University, San Marco, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Wynn","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Florida, College of Medicine, Gainesville, Florida"},{"name":"Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Clinical Research Informatics, Rady Children's Hospital San Diego, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics, University of California, San Diego, College of Medicine, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lazar","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of California, San Diego, College of Medicine, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley M.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of California, San Diego, College of Medicine, San Diego, California"},{"name":"Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1542\/peds.2005-0620C","article-title":"Summary proceedings from the neonatal pain-control group","volume":"117","author":"K J 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