{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:44Z","timestamp":1740126824980,"version":"3.37.3"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Background Adequate pharmacological treatment is of pivotal importance to improve prognosis in patients with decompensated liver cirrhosis. We studied the adherence to recommended pharmacological treatments as secondary prevention in cirrhotic patients following a first decompensation in German primary care.<\/jats:p><jats:p>\n               Methods Using the Disease Analyzer Database, the current study sample included patients with liver cirrhosis who had an initial diagnosis of a first decompensation event between 2015 and 2018 (index date) and a follow-up time of at least 6 months after the index date. Pharmacological treatments following the 6 months after the index date were studied.<\/jats:p><jats:p>\n               Results The study included 1538 patients with a first decompensation event. The frequency of first-time complications of cirrhosis was 60% new onset of ascites, 25% overt hepatic encephalopathy (HE), 3% spontaneous bacterial peritonitis (SBP), and 12% acute variceal bleeding. The adherence to guideline-recommended treatment following the initial decompensation was highest for ascites, with 91.3% of patients receiving diuretics. Non-selective beta-blockers following an event of variceal bleeding were prescribed in 69.1% and lactulose and\/or rifaximin in 59.1% after a bout of HE. The frequency of prescriptions of antibiotics after SBP was 60.4%. Potenzially harmful prescribed medications included non-steroidal anti-inflammatory drugs in 15.5%, benzodiazepines in 12.8%, opioids in 9.5%, and proton pump inhibitors in 73.7%.<\/jats:p><jats:p>\n               Conclusion Our findings underline the need for intensified efforts to distribute practice guidelines for liver cirrhosis and increase awareness of over-prescribing of potentially harmful medication.<\/jats:p>","DOI":"10.1055\/a-1676-4822","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T01:42:47Z","timestamp":1637804567000},"page":"165-169","source":"Crossref","is-referenced-by-count":0,"title":["Prescription rates of common medications in patients with decompensated cirrhosis in Germany"],"prefix":"10.1055","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8390-9663","authenticated-orcid":false,"given":"Christian","family":"Labenz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Kostev","sequence":"additional","affiliation":[{"name":"IQVIA Germany, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Robert","family":"Galle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus-Alexander","family":"W\u00f6rns","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rn M.","family":"Schattenberg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1002\/hep.23500","article-title":"Clinical course of alcoholic liver cirrhosis: a Danish population-based cohort study","volume":"51","author":"P Jepsen","year":"2010","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jhep.2018.03.024","article-title":"European Association for the Study of the L. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis","volume":"69","author":"European Association for the Study of the Liver","year":"2018","journal-title":"J Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1055\/a-0873-4658","article-title":"Updated S2k-Guideline \u201cComplications of liver cirrhosis.\u201d German Society of Gastroenterology (DGVS)","volume":"57","author":"AL Gerbes","year":"2019","journal-title":"Z Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1002\/hep.31548","article-title":"Appropriate and potentially inappropriate medication use in decompensated cirrhosis","volume":"73","author":"MJ Thomson","year":"2020","journal-title":"Hepatology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1111\/apt.16008","article-title":"Proton pump inhibitors increase risk of bone fractures in men with cirrhosis: a population-based study","volume":"52","author":"C Labenz","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1002\/hep4.1541","article-title":"Nonalcoholic fatty liver disease increases the risk of anxiety and depression","volume":"4","author":"C Labenz","year":"2020","journal-title":"Hepatol Commun"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/hep.30304","article-title":"Proton pump inhibitors are associated with minimal and overt hepatic encephalopathy and increased mortality in patients with cirrhosis","volume":"70","author":"S Nardelli","year":"2019","journal-title":"Hepatology"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e23436","DOI":"10.1097\/MD.0000000000023436","article-title":"Proton pump inhibitor use is associated with a variety of infections in patients with liver cirrhosis","volume":"99","author":"C Labenz","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1002\/hep.28598","article-title":"Nonabsorbable disaccharides for hepatic encephalopathy: A systematic review and meta-analysis","volume":"64","author":"LL Gluud","year":"2016","journal-title":"Hepatology"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1056\/NEJMoa0907893","article-title":"Rifaximin treatment in hepatic encephalopathy","volume":"362","author":"NM Bass","year":"2010","journal-title":"New Engl J Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1055\/a-1010-6974","article-title":"Management of hepatic encephalopathy in Germany: a survey among physicians","volume":"58","author":"C Labenz","year":"2020","journal-title":"Z Gastroenterol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1016\/S0140-6736(17)32808-8","article-title":"The opioid crisis in the USA: a public health emergency","volume":"390","author":"L The","year":"2017","journal-title":"Lancet"}],"container-title":["Zeitschrift f\u00fcr Gastroenterologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1676-4822.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:13:48Z","timestamp":1644624828000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1676-4822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":12,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2022,2,11]]},"published-print":{"date-parts":[[2022,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1676-4822","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0044-2771","1439-7803"],"issn-type":[{"type":"print","value":"0044-2771"},{"type":"electronic","value":"1439-7803"}],"subject":[],"published":{"date-parts":[[2021,11,24]]}}}