{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:23:50Z","timestamp":1783038230466,"version":"3.54.6"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Pituitary adenomas (PAs) are one of the most common types of intracranial neoplasm with increased incidence in elderly patients. The outcomes of endoscopic transsphenoidal surgery (ETS) specifically on elderly patients remain unclear.<\/jats:p><jats:p>\n          Methods\u2003We performed a retrospective cohort study to compare elderly patients (age \u226565 years) with nonelderly patients (age &lt;65 years) who underwent ETS for PA from January 2005 to December 2020. Surgical outcomes, including extent of resection, complication profile, length of stay, and endocrinopathy rates, were compared between elderly and nonelderly patients.<\/jats:p><jats:p>\n          Results\u2003A total of 690 patients were included, with 197 (29%) being elderly patients. Elderly patients showed higher rates of hypertension (p\u2009&lt;\u20090.05), myocardial infarction (p\u2009&lt;\u20090.01), and atrial fibrillation (p\u2009=\u20090.01) but not other comorbidities. Elderly patients also had more frequent optic nerve involvement (72 vs. 61% of cases, p\u2009=\u20090.01). Tumor characteristics and other patient variables were otherwise similar between younger and elderly patients. Postoperative cerebrospinal fluid (CSF) leaks (2 vs. 2%, p\u2009=\u20090.8), 30-day readmission, reoperation, postoperative complications, and postoperative endocrinopathies were similar between younger and older patients. Subdividing patients into age &lt;65, 65 to 79, and &gt;80 years also did not demonstrate a worsening of surgical outcomes with age.<\/jats:p><jats:p>\n          Conclusion\u2003For well-selected elderly patients in experienced endoscopic skull base centers, good surgical outcomes similarly to younger patients may be achieved.<\/jats:p>","DOI":"10.1055\/a-1680-1572","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T22:38:38Z","timestamp":1635374318000},"page":"405-410","source":"Crossref","is-referenced-by-count":8,"title":["Surgical Outcomes of Endoscopic Transsphenoidal Pituitary Adenoma Resection in Elderly Versus Younger Patients"],"prefix":"10.1055","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6886-9189","authenticated-orcid":false,"given":"Tyler D.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandala","family":"Chitguppi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Collopy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-4806","authenticated-orcid":false,"given":"Pascal","family":"Lavergne","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawfiq","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy","family":"Rabinowitz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurston G.","family":"Nyquist","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Karsy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1056\/NEJMra1810772","article-title":"Pituitary-tumor endocrinopathies","volume":"382","author":"S Melmed","year":"2020","journal-title":"N Engl J Med"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11102-018-0869-3","article-title":"Epidemiology, clinical presentation and diagnosis of non-functioning pituitary adenomas","volume":"21","author":"G Ntali","year":"2018","journal-title":"Pituitary"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3171\/2014.5.JNS131819","article-title":"Descriptive epidemiology of pituitary tumors in the United States, 2004-2009","volume":"121","author":"H 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Chen","year":"2019","journal-title":"World Neurosurg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.wneu.2017.06.151","article-title":"Risks and benefits of endoscopic transsphenoidal surgery for nonfunctioning pituitary adenomas in patients of the ninth decade","volume":"106","author":"R Chinezu","year":"2017","journal-title":"World Neurosurg"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3171\/2014.10.JNS14372","article-title":"Endoscopic endonasal transsphenoidal surgery in elderly patients with pituitary adenomas","volume":"123","author":"J A Gondim","year":"2015","journal-title":"J Neurosurg"},{"issue":"09","key":"ref9","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1590\/0004-282X20150112","article-title":"Surgical treatment of non-functioning pituitary macroadenomas by the endoscopic endonasal approach in the elderly","volume":"73","author":"H A Marenco","year":"2015","journal-title":"Arq 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and Complications in 158 Patients","volume":"6","author":"R Zhan","journal-title":"World Neurosurgery"}],"container-title":["Journal of Neurological Surgery Part B: Skull Base"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1680-1572.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T10:45:53Z","timestamp":1660128353000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1680-1572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,27]]},"references-count":22,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,7,26]]},"published-print":{"date-parts":[[2022,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1680-1572","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6331","2193-634X"],"issn-type":[{"value":"2193-6331","type":"print"},{"value":"2193-634X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10,27]]},"published":{"date-parts":[[2021,10,27]]}}}