{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:02:43Z","timestamp":1740168163555,"version":"3.37.3"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sepsis is a severe systemic inflammatory response with high mortality rate\n                    resulting from different microorganisms. Cytokines activation is essential for\n                    the immune response, but in painful conditions like sepsis, cytokines act as a\n                    double-edged sword and dysregulate immune response which is life-threatening\n                    owing to multiple organ dysfunction. The abnormality in 5-HT function is\n                    involved in pathological conditions like irritable bowel syndrome, inflammation,\n                    myocardial ischemia, itch and renal injury. Sumatriptan, a\n                        5-HT1B\/1D agonist, has anti-inflammatory and\n                    anti-oxidative stress effects on animal models. This study was aimed to assess\n                    the effects of sumatriptan on kidney injury, the levels of pro-inflammatory\n                    cytokines and the percentage of survival in (CLP)-induced sepsis were\n                    examined.<\/jats:p><jats:p>Cecal ligation and puncture (CLP) model was done on adult C57BL\/6 male\n                    mice to induce Polymicrobial sepsis. Sumatriptan was injected intraperitoneally\n                    1\u2009h after the sepsis induction by CLP at doses of 0.1, 0.3, and\n                    1\u2009mg\/kg in 3 treatment groups. To study the effect of\n                    sumatriptan on short-term survival, septic animals were detected 72\u2009h\n                    after CLP. Serum levels of TNF-\u03b1, IL-1\u03b2, IL-6 and IL-10 were\n                    evaluated. To study sepsis-induced acute renal failure, kidney functional\n                    biomarkers and histopathological alterations were evaluated.<\/jats:p><jats:p>Sumatriptan (0.3\u2009mg\/kg) administration significantly enhanced\n                    survival rate (P&lt;0.01) compared to the CLP group. The beneficial effects\n                    of sumatriptan were related to a significant decrease in the pro-inflammatory\n                    cytokines and elevated level of IL-10. Sumatriptan presented protective effects\n                    on kidney biomarkers and histopathology assay.<\/jats:p><jats:p>Anti-inflammatory effects of sumatriptan lead to decrease mortality rate and\n                    inflammatory cytokines in CLP induction sepsis in C57BL\/6 mice.<\/jats:p>","DOI":"10.1055\/a-1685-0482","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:07:53Z","timestamp":1638403673000},"page":"156-162","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of Sumatriptan on Sepsis-Induced Kidney injury in the\n                    Cecal Ligation and Puncture Mice Model"],"prefix":"10.1055","volume":"72","author":[{"given":"Hasan","family":"Yousefi-Manesh","sequence":"first","affiliation":[{"name":"Experimental Medicine Research Center, Tehran University of Medical\n                    Sciences, Tehran, Iran"},{"name":"Department of Pharmacology, School of Medicine, Tehran University of\n                    Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5000-3387","authenticated-orcid":false,"given":"Samira","family":"Shirooie","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Health Institute, Kermanshah\n                    University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayebeh","family":"Noori","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Health Institute, Kermanshah\n                    University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Mohammad","family":"Tavangar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. Shariati Hospital, Tehran University of\n                    Medical Sciences, Tehran, Iran"},{"name":"Chronic Diseases Research Center, Endocrinology and Metabolism\n                    Population Sciences Institute, Tehran University of Medical Sciences, Tehran,\n                    Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Sheibani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Iran University of\n                    Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Chaboki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of\n                    Medical Sciences, Tehran, Iran"},{"name":"School of Pharmacy, Tehran University of Medical Sciences, Tehran,\n                    Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of\n                    Medical Sciences, Tehran, Iran"},{"name":"School of Pharmacy, Tehran University of Medical Sciences, Tehran,\n                    Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[{"name":"Experimental Medicine Research Center, Tehran University of Medical\n                    Sciences, Tehran, Iran"},{"name":"Department of Pharmacology, School of Medicine, Tehran University of\n                    Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1177\/0300060518764717","article-title":"Assessment of clinical sepsis-associated biomarkers in a septic mouse model","volume":"46","author":"J-L Li","year":"2018","journal-title":"Journal of International Medical 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Nano"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cca.2020.12.004","article-title":"Functional role of iNOS-Rac2 interaction in neutrophil extracellular traps\n                    (NETs) induced cytotoxicity in sepsis","volume":"513","author":"S Kumar","year":"2021","journal-title":"Clinica Chimica Acta"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.intimp.2017.11.038","article-title":"LncRNA MALAT1 regulates sepsis-induced cardiac inflammation and dysfunction via\n                    Interaction with miR-125b and p38 MAPK\/NF\u03baB","volume":"55","author":"H Chen","year":"2018","journal-title":"International immunopharmacology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bios.2018.02.013","article-title":"A review on electrochemical detection of serotonin based on surface modified\n                    electrodes","volume":"107","author":"S Sharma","year":"2018","journal-title":"Biosensors and Bioelectronics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41231-020-00081-y","article-title":"The role of serotonin and diet in the prevalence of irritable bowel syndrome: A\n                    systematic review","volume":"6","author":"K Bruta","year":"2021","journal-title":"Translational Medicine Communications"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00403-018-1809-9","article-title":"Attenuation of serotonin-induced itch by sumatriptan: possible involvement of\n                    endogenous opioids","volume":"310","author":"N-S Haddadi","year":"2018","journal-title":"Archives of Dermatological Research"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2147\/NDT.S157441","article-title":"Beneficial effects of trimetazidine on expression of serotonin and serotonin\n                    transporter in rats with myocardial infarction and depression","volume":"14","author":"M Liu","year":"2018","journal-title":"Neuropsychiatric Disease and Treatment"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1212\/WNL.45.2.219","article-title":"Serotonin syndrome","volume":"45","author":"R A Bodner","year":"1995","journal-title":"Neurology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1056\/NEJM199108013250504","article-title":"Treatment of migraine attacks with sumatriptan","volume":"325","year":"1991","journal-title":"New England Journal of Medicine"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1001\/archneur.59.7.1084","article-title":"Mechanisms of action of the 5-HT1B\/1D receptor agonists","volume":"59","author":"S J Tepper","year":"2002","journal-title":"Archives of Neurology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neuro.2018.06.012","article-title":"The protective effects of sumatriptan on vincristine-induced peripheral\n                    neuropathy in a rat model","volume":"67","author":"M Khalilzadeh","year":"2018","journal-title":"Neurotoxicology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s10787-019-00586-5","article-title":"Sumatriptan protects against myocardial ischaemia\u2013reperfusion injury by\n                    inhibition of inflammation in rat model","volume":"27","author":"M Sheibani","year":"2019","journal-title":"Inflammopharmacology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1139\/cjpp-2019-0301","article-title":"The effects of acute sumatriptan treatment on renal ischemia\/reperfusion\n                    injury in rat and the possible involvement of nitric oxide","volume":"98","author":"P Mobasheran","year":"2020","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/01.shk.0000191414.94461.7e","article-title":"Cecal ligation and puncture","volume":"24","author":"W J Hubbard","year":"2005","journal-title":"Shock"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"D Rittirsch","year":"2009","journal-title":"Nature Protocols"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/SHK.0000000000000318","article-title":"Refinement of animal models of sepsis and septic shock","volume":"43","author":"E Lilley","year":"2015","journal-title":"Shock"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"840","DOI":"10.4103\/0366-6999.202734","article-title":"Sub-anesthesia dose of isoflurane in 60% oxygen reduces inflammatory\n                    responses in experimental sepsis models","volume":"130","author":"Y Huang","year":"2017","journal-title":"Chinese Medical Journal"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40635-016-0096-z","article-title":"Sepsis modeling in mice: ligation length is a major severity factor in cecal\n                    ligation and puncture","volume":"4","author":"S Ruiz","year":"2016","journal-title":"Intensive Care Medicine Experimental"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e13358","DOI":"10.1111\/and.13358","article-title":"Protective effects of sumatriptan on ischaemia\/reperfusion injury\n                    following torsion\/detorsion in ipsilateral and contralateral testes of\n                    rat","volume":"51","author":"P Dejban","year":"2019","journal-title":"Andrologia"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s10787-019-00586-5","article-title":"Sumatriptan protects against myocardial ischaemia-reperfusion injury by\n   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sepsis-induced organ dysfunction","volume":"35","author":"E Abraham","year":"2007","journal-title":"Critical care medicine"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuroscience.2016.01.045","article-title":"Increased levels of brain serotonin correlated with MMP-9 activity and IL-4\n                    levels resulted in severe experimental autoimmune encephalomyelitis (EAE) in\n                    obese mice","volume":"319","author":"M Hasan","year":"2016","journal-title":"Neuroscience"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1189\/jlb.1103595","article-title":"Oxygen radical-induced natural killer cell dysfunction: role of myeloperoxidase\n                    and regulation by serotonin","volume":"75","author":"\u00c5 Betten","year":"2004","journal-title":"Journal of Leukocyte Biology"},{"key":"ref36","first-page":"22747","article-title":"Sepsis-induced elevation in plasma serotonin facilitates endothelial\n 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action potential in rat models","volume":"110","author":"Z Liu","year":"2019","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1468-2982.1991.1104165.x","article-title":"Evidence for 5-HT1B\/1D receptors mediating the antimigraine effect of\n                    sumatriptan and dihydroergotamine","volume":"11","author":"M G Buzzi","year":"1991","journal-title":"Cephalalgia"},{"key":"ref41","first-page":"219","article-title":"Dual effect of the serotonin agonist, sumatriptan, on peripheral neurogenic\n                    inflammation","volume":"21","author":"P A Pierce","year":"1996","journal-title":"Regional Anesthesia: The Journal of Neural Blockade in Obstetrics,\n                    Surgery, & Pain Control"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/exnr.2000.7521","article-title":"Inhibition of inflammation-induced thermal hypersensitivity by sumatriptan\n                    through activation of 5-HT1B\/1D receptors","volume":"167","author":"S Bingham","year":"2001","journal-title":"Experimental Neurology"}],"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1685-0482.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T23:59:39Z","timestamp":1646697579000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1685-0482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":35,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2022,3,7]]},"published-print":{"date-parts":[[2022,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1685-0482","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"type":"print","value":"2194-9379"},{"type":"electronic","value":"2194-9387"}],"subject":[],"published":{"date-parts":[[2021,12,1]]}}}