{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T09:08:59Z","timestamp":1743325739678,"version":"3.37.3"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>According to the recent studies, immunohistochemical subtypes of growth hormone\n                    (GH) secreting adenomas have been considered as a predictive factor in\n                    determining the clinical outcomes including biochemical, radiologic, and\n                    endocrine remission. In a 20 year-of time period, acromegaly patients who were\n                    treated and followed at the Endocrinology Department of our University Hospital\n                    were screened for the study. Of total 98 patients, 65 patients who had been\n                    operated by transsphenoidal surgery and having postoperative specimens were\n                    included. Postoperative specimens of the surgery of the patients were classified\n                    into 3 groups based on the histochemical characteristics (densely, sparsely, and\n                    mixed). Parasellar extensions of pituitary tumors were classified into the five\n                    grades according to Knosp classification. The patients were investigated and\n                    evaluated for postoperative clinical progress, remission rates, comorbidities\n                    regarding with the histopathological patterns. Of total 65 patients, 31 were\n                    classified as densely granulated (group 1), 32 were classified as sparsely\n                    granulated (group 2), and 2 patients were assessed as mixed granulated (group\n                    3). There was no difference between groups for age and gender. Pre-treatment of\n                    adenoma size in all groups was correlated with each other and the frequency of\n                    macroadenoma (1 vs. 2, 77.4 vs. 84.3%) was higher in two groups.\n                    Although mean initial GH levels in group 1 was higher than the other groups\n                    (p=0.03), IGF1 levels (age and gender matched) were similar in each\n                    group. Adenomas in all groups demonstrated noninvasive radiological\n                    characteristics (Knosp grade 0\u20131\u20132). Ki-67 proliferation index\n                    of both groups (64.5 vs. 50%) was predominantly 1%. With a\n                    similar follow-up period, the endocrine remission rates\n                    (GH&lt;1\u2009\u03bcg\/l) in groups were 64 vs. 69%,\n                    respectively. In conclusion, classification according to immunohistochemical\n                    subtypes of growth hormone secreting adenomas may not be a qualified parameter\n                    to evaluate patients with patterns of aggressiveness, clinical outcomes, or\n                    treatment response.<\/jats:p>","DOI":"10.1055\/a-1685-0655","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:19:58Z","timestamp":1638231598000},"page":"37-41","source":"Crossref","is-referenced-by-count":5,"title":["Novel Classification of Acromegaly in Accordance with\n                    Immunohistochemical Subtypes: Is There Really a Clinical\n                    Relevance?"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-159X","authenticated-orcid":false,"given":"Gamze","family":"Akkus","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Cukurova University, Adana,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulya","family":"Odaba\u015f","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Cukurova University, Adana,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinan","family":"S\u00f6z\u00fctok","sequence":"additional","affiliation":[{"name":"Division of Radiology, Cukurova University, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Sert","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Cukurova University, Adana,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Numan Emre","family":"Ak","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Cukurova University, Adana,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehtap","family":"Evran","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Cukurova University, Adana,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamer","family":"Tetiker","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Cukurova University, Adana,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMra062453","article-title":"Medical progress: Acromegaly","volume":"14","author":"S Melmed","year":"2006","journal-title":"N Eng J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1210\/jc.2008-2421","article-title":"Guidelines for acromegaly management: An update","volume":"94","author":"S Melmed","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s12022-008-9029-z","article-title":"Clinicopathological features of growth hormone-producing pituitary adenomas:\n                    Difference among various types defined by cytokeratin distribution pattern\n                    including a transitional form","volume":"19","author":"A Obari","year":"2008","journal-title":"Endocr Pathol"},{"key":"ref4","first-page":"20","article-title":"Growth hormone-producing pituitary adenomas: Correlations between clinical\n                    characteristics and morphology","volume":"33","author":"S Yamada","year":"1993","journal-title":"Neurosurgery"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1530\/EJE-10-0586","article-title":"Relationship between cytokeratin staining patterns and clinico-pathological\n                    features in somatotropinomae","volume":"163","author":"Y Bakhtiar","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1530\/EJE-13-0134","article-title":"Molecular and functional properties of densely and sparsely granulated\n                    GH-producing pituitary adenomas","volume":"169","author":"B Mayr","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.beem.2009.05.004","article-title":"The pathophysiology of pituitary adenomas","volume":"23","author":"D Dworakowska","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00000478-198304000-00004","article-title":"Prolactin and growth hormone-producing pituitary adenomas. 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