{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T13:51:42Z","timestamp":1673704302591},"reference-count":6,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Anamnese und klinischer Befund\u2002Die Vorstellung des 79-j\u00e4hrigen Patienten erfolgte bei rezidivierenden Fieberepisoden, Gewichtsverlust, Nachtschwei\u00df, deutlicher Abnahme der Belastbarkeit sowie fl\u00e4chigen H\u00e4matomen an den Extremit\u00e4ten.<\/jats:p><jats:p>\n          Untersuchungen\u2002In der durchgef\u00fchrten Laboruntersuchung zeigte sich eine Panzytopenie bei eingeschr\u00e4nkter Nierenfunktion sowie erh\u00f6htem CRP. Sonografisch konnte eine Splenomegalie nachgewiesen werden. Es erfolgte eine Knochenmarkspunktion.<\/jats:p><jats:p>\n          Diagnose\u2002In der Knochenmarkbiopsie konnte histologisch die Diagnose einer viszeralen Leishmaniasis gestellt werden, welche mittels PCR aus dem peripheren Blut best\u00e4tigt wurde.<\/jats:p><jats:p>\n          Therapie und Verlauf\u2002Unter der Therapie mit liposomalem Amphotericin B kam es zu einer deutlichen Besserung der Panzytopenie sowie einem Abfall des CRP. Die Nierenfunktion erholte sich nach initialer Verschlechterung nur langsam. Fieber trat nicht mehr auf.<\/jats:p><jats:p>\n          Folgerung\u2002Bei Vorliegen einer Panzytopenie mit entsprechender klinischer Symptomatik sollte bei m\u00f6glicher Exposition auch bei vermeintlich immunkompetenten Patienten an eine viszerale Leishmaniasis gedacht werden.<\/jats:p>","DOI":"10.1055\/a-1685-5173","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T23:30:31Z","timestamp":1643671831000},"page":"108-111","source":"Crossref","is-referenced-by-count":1,"title":["Panzytopenie und B-Symptomatik \u2013 unerwartetes Souvenir?"],"prefix":"10.1055","volume":"147","author":[{"given":"Benjamin","family":"Gebel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Infektiologie und Mikrobiologie, Universit\u00e4tsklinikum Schleswig-Holstein, Campus L\u00fcbeck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Rupp","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Infektiologie und Mikrobiologie, Universit\u00e4tsklinikum Schleswig-Holstein, Campus L\u00fcbeck"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Kramme","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Infektiologie und Mikrobiologie, Universit\u00e4tsklinikum Schleswig-Holstein, Campus L\u00fcbeck"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.3109\/10428194.2013.821703","article-title":"New onset pancytopenia in adults: a\u00a0review of underlying pathologies and their associated clinical and laboratory findings","volume":"55","author":"K A Devitt","year":"2014","journal-title":"Leuk Lymphoma"},{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1309\/AJCP50AEEYGREWUZ","article-title":"The differential diagnosis and bone marrow evaluation of new-onset pancytopenia","volume":"139","author":"E P Weinzierl","year":"2013","journal-title":"Am J Clin Pathol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"361058","DOI":"10.1155\/2014\/361058","article-title":"Bacterial sepsis in patients with visceral leishmaniasis in Northwest Ethiopia","volume":"2014","author":"M Endris","year":"2014","journal-title":"Biomed Res Int"},{"issue":"04","key":"ref8","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.bjid.2013.11.013","article-title":"Kidney involvement in leishmaniasis--a review","volume":"18","author":"G B Silva Junior","year":"2014","journal-title":"Braz J Infect Dis"},{"issue":"01","key":"ref9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1128\/CMR.19.1.111-126.2006","article-title":"Drug resistance in leishmaniasis","volume":"19","author":"S L Croft","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"9872095","DOI":"10.1155\/2018\/9872095","article-title":"Current Visceral Leishmaniasis Research: A\u00a0Research Review to Inspire Future Study","volume":"2018","author":"K Bi","year":"2018","journal-title":"Biomed Res Int"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1685-5173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T23:31:28Z","timestamp":1643671888000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1685-5173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":6,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2022,1,31]]},"published-print":{"date-parts":[[2022,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1685-5173","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}