{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T18:42:36Z","timestamp":1648838556181},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund\u2002Anhaltende neurologische Sp\u00e4tsymptome einer SARS-CoV-2-Infektion sind h\u00e4ufig und erfordern regelm\u00e4\u00dfig eine Anschlussheilbehandlung. Zur Etablierung einheitlicher Therapiekonzepte ist die Evaluierung individueller Therapieans\u00e4tze bei Long- und Post-Covid-Syndrom erforderlich.<\/jats:p><jats:p>\n          Anamnese\u2002Ein 62-j\u00e4hriger Patient wurde nach schwerem Verlauf einer SARS-CoV-2-Infektion mit neurologischen Symptomen zur Anschlussheilbehandlung in unserer Reha-Klinik aufgenommen. Die initial umfangreiche laborchemische und bildgebende Abkl\u00e4rung ergab keine organische Ursache f\u00fcr das teils apoplektiforme, komplexe Krankheitsbild, sodass bei Alltagseinschr\u00e4nkungen und Rollatorabh\u00e4ngigkeit die Direktverlegung in unsere Rehabilitationsklinik erfolgte.<\/jats:p><jats:p>\n          Untersuchung und Befunde\u2002Klinisch zeigte sich ein reduzierter Allgemeinzustand bei gedr\u00fcckter Stimmungslage. Neurologisch imponierte eine Gangataxie, ein H\u00e4ndetremor, eine amnestische Aphasie und verminderte Konzentrationsf\u00e4higkeit. Eine PET\/CT ergab keinen Hinweis auf einen Tumor oder eine Entz\u00fcndung.<\/jats:p><jats:p>\n          Therapie und Verlauf\u2002Ein multimodales Therapieprogramm, bestehend aus Physio- und Ergotherapie sowie psychologischer Mitbetreuung wurde durchgef\u00fchrt. Zudem wurde eine Off-Label-Therapie mit oralen Glucocorticoiden und Colchicin initiiert. Im Verlauf kam es zu einer klaren Reduktion aller Symptome mit geringem residuellen H\u00e4ndetremor.<\/jats:p><jats:p>\n          Folgerung\u2002Bei Long- und Post-Covid-Patienten mit neurologischen Symptomen unklarer Ursache kann eine Ganzk\u00f6rper- und Hirn-FDG-PET hilfreich sein. Diese Patienten profitieren von einer systematischen Rehabilitation. Glucocorticoide und Colchicin scheinen die Symptomreduktion zu beschleunigen. Die rehabilitative Therapie sollte ambulant fortgesetzt werden.<\/jats:p>","DOI":"10.1055\/a-1689-6188","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T23:34:46Z","timestamp":1644881686000},"page":"173-177","source":"Crossref","is-referenced-by-count":0,"title":["Neurologische Sp\u00e4tfolgen einer SARS-CoV-2-Infektion"],"prefix":"10.1055","volume":"147","author":[{"given":"Enrico","family":"Michler","sequence":"additional","affiliation":[{"name":"Klinik u. Poliklinik f. Nuklearmedizin, Universit\u00e4tsklinikum Carl Gustav Carus Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliia","family":"Dolzhenko","sequence":"additional","affiliation":[{"name":"Median Klinik f\u00fcr Kardiologie Bad Gottleuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Altmann","sequence":"additional","affiliation":[{"name":"Median Klinik f\u00fcr Kardiologie Bad Gottleuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"ref3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00115-021-01104-1","article-title":"Neurovaskul\u00e4re Manifestationen von COVID-19","volume":"92","author":"R Veltkamp","year":"2021","journal-title":"Nervenarzt"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1007\/s00259-021-05375-3","article-title":"A comprehensive review of imaging findings in COVID-19 \u2013 status in early 2021","volume":"48","author":"A Afshar-Oromieh","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.2967\/jnumed.120.249292","article-title":"Autoimmune encephalitis concomitant with SARS-CoV-2 infection: insight from 18F-FDG PET imaging and neuronal autoantibodies","volume":"61","author":"S Grimaldi","year":"2020","journal-title":"J Nucl Med"},{"key":"ref6","first-page":"1","article-title":"Long COVID hallmarks on [18F] FDG-PET\/CT: a case-control study","volume":"7","author":"M Sollini","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"17","key":"ref8","first-page":"A-892","article-title":"COVID-19-Therapie: Cortison-Sto\u00dftherapie","volume":"1177","author":"M Sch\u00fctz","year":"2020","journal-title":"Dtsch Arztebl"},{"issue":"42","key":"ref9","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1093\/eurheartj\/ehv318","article-title":"2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC)Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS)","volume":"36","author":"Y Adler","year":"2015","journal-title":"Eur Heart J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s15027-020-2168-y","article-title":"Ist Colchicin eine neue Therapieoption bei stabiler KHK?","volume":"20","author":"D Einecke","year":"2020","journal-title":"CV"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"106322","DOI":"10.1016\/j.rmed.2021.106322","article-title":"Colchicine and SARS-COV-2: Management of the hyperinflammatory state","volume":"178","author":"A Vitiello","year":"2021","journal-title":"Respiratory Medicine"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s15027-021-3495-3","article-title":"COVID-19: Studie mit Colchicin wegen fehlender Wirkung gestoppt","volume":"21","author":"V Schlimpert","year":"2021","journal-title":"CV"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1689-6188.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T23:36:22Z","timestamp":1644881782000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1689-6188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":9,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,2,14]]},"published-print":{"date-parts":[[2022,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1689-6188","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}