{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:16:48Z","timestamp":1787858208319,"version":"build-2784847793"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"13","funder":[{"DOI":"10.13039\/501100005672","name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do\n\t\t\t\t\t\tSul","doi-asserted-by":"crossref","award":["59\/300.046\/2015 and 71\/700.135\/2018"],"award-info":[{"award-number":["59\/300.046\/2015 and 71\/700.135\/2018"]}],"id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["449464\/2014-8 and 407685\/2018-9"],"award-info":[{"award-number":["449464\/2014-8 and 407685\/2018-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Blutaparon portulacoides is a Brazilian plant species that is widely used in folk medicine. The present study investigated the role of an aqueous extract of B. portulacoides\n\t\t\t\t\tagainst hypertension in spontaneously hypertensive rats. The aqueous extract of B. portulacoides was obtained from the whole plant. Its chemical profile was analyzed by\n\t\t\t\t\tultraperformance liquid chromatography-tandem mass spectrometry. The acute toxicity of the aqueous extract of B. portulacoides was evaluated in female Wistar rats. Male 6-month-old\n\t\t\t\t\tspontaneously hypertensive rats then received the aqueous extract of B. portulacoides (30, 100, and 300\u2009mg\/kg), hydrochlorothiazide (25\u2009mg\/kg), or vehicle once daily for 28 days. On\n\t\t\t\t\tdays 1, 14, and 28, the diuretic effects of the aqueous extract of B. portulacoides were evaluated. The role of prostaglandins and the nitric oxide-cyclic guanosine\n\t\t\t\t\tmonophosphate-potassium channel pathway in the diuretic activity of the aqueous extract of B. portulacoides was also investigated. At the end of the treatment, hepatic and renal\n\t\t\t\t\tbiochemical markers, serum nitrotyrosine, malondialdehyde, nitrite, and aldosterone levels, and angiotensin-converting enzyme activity were measured. The electrocardiographic profile, blood\n\t\t\t\t\tpressure, and renal vascular reactivity were also assessed. The heart, kidneys, and liver were collected to determine relative organ weight, histopathology, and cardiac morphometry. Caffeic\n\t\t\t\t\tacid, ferulic acid, and several flavonoids were identified in the aqueous extract of B. portulacoides. No signs of toxicity were observed. Prolonged treatment with the aqueous extract\n\t\t\t\t\tof B. portulacoides (300\u2009mg\/kg) induced significant diuretic activity by activating the nitric oxide-cyclic guanosine monophosphate-potassium channel pathway. These effects reduced\n\t\t\t\t\tblood pressure and oxidative stress and prevented renal vascular dysfunction and left ventricular hypertrophy that was induced by hypertension. Overall, the present data suggest that the\n\t\t\t\t\taqueous extract of B. portulacoides has important diuretic and cardioprotective effects by activation of the nitric oxide-cyclic guanosine monophosphate-potassium channel pathway.<\/jats:p>","DOI":"10.1055\/a-1690-3566","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T23:38:16Z","timestamp":1647560296000},"page":"1152-1162","source":"Crossref","is-referenced-by-count":4,"title":["The NO-cGMP-K+ Channel Pathway Participates in Diuretic and Cardioprotective Effects of Blutaparon portulacoides in Spontaneously Hypertensive\n\t\t\t\t\tRats"],"prefix":"10.1055","volume":"88","author":[{"given":"Patr\u00edcia Regina","family":"Ter\u00e7o Leite","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth\u00e2nia Rosa","family":"Loren\u00e7one","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karyne Garcia Tafarelo","family":"Moreno","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katiana Sim\u00f5es","family":"Lopes","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Aparecida Macedo","family":"Marques","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Soligo","family":"Fortini","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhanany Alan Calloi","family":"Palozi","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Dalmagro","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology Applied to Agriculture, Paranaense University, Umuarama, Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e2ndida Aparecida Leite","family":"Kassuya","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoinflammation and Cell Culture, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariany Carvalho","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Histology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Jos\u00e9","family":"Salvador","sequence":"additional","affiliation":[{"name":"Institute of Biology, Department of Plant Biology, University of Campinas, Campinas, S\u00e3o Paulo, 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