{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:41:28Z","timestamp":1790710888702,"version":"4.1.0"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Das Glaukom, eine multifaktorielle neurodegenerative Erkrankung, ist die zweith\u00e4ufigste Ursache f\u00fcr Erblindungen. Da eine Fr\u00fcherkennung die rechtzeitige Behandlung erm\u00f6glicht, ist es notwendig, entsprechende Marker zu finden. F\u00fcr eine Fr\u00fcherkennung oder auch eine Kontrolle im Behandlungsverlauf. k\u00f6nnten sog. Biomarker in Zukunft von Nutzen sein. Beim Glaukom k\u00f6nnten diese Messwerte im Kammerwasser bestimmt werden. So wurden bereits ver\u00e4nderte Antik\u00f6rper-, Protein-, microRNA- (miRNA), oder Spurenelementlevel nachgewiesen. Dieser \u00dcbersichtsartikel gibt einen Einblick in m\u00f6gliche Ver\u00e4nderungen im Kammerwasser von Patienten mit prim\u00e4ren Offenwinkelglaukom (POWG), Normaldruckglaukom (NDG) oder Pseudoexfoliationsglaukom (PEXG). Untersuchungen zu Antik\u00f6rperver\u00e4nderungen konnten bei POWG-Patienten eine Hochregulation von Antik\u00f6rpern detektieren, die mit dem Immunsystem assoziiert sind, wie z.\u200aB. das Hitzeschockprotein (HSP) 27. Das HSP27 lag auch bei PEXG-Patienten hoch-, beim NDG hingegen herunterreguliert vor. In POWG- und PEXG-Proben konnten erh\u00f6hte Werte bestimmter Proteine, u.\u200aa. Interleukine und Endothelin-1, gemessen werden. Endothelin-1 ist ein Vasokonstriktor und spielt m\u00f6glicherweise eine Rolle bei der Regulation des Augeninnendrucks. Proteine, die bei der Antwort gegen oxidativen Stress eine Rolle spielen, wurden hingegen in verringerter Konzentration vorgefunden. Beim NDG waren Proteine, die f\u00fcr die Beseitigung von toxischen Nebenprodukten der Atmungskette zust\u00e4ndig sind, herunterreguliert. Es konnten au\u00dferdem verschiedene miRNAs im Kammerwasser von POWG- und PEXG-Patienten identifiziert werden, die im Zusammenhang mit der Entwicklung von Geweben, neurologischen Erkrankungen und zellul\u00e4rer Organisation stehen. Weitere beim Glaukom regulierte miRNAs spielen eine Rolle bei der Remodellierung der extrazellul\u00e4ren Matrix und k\u00f6nnten so einen Einfluss auf den Abflusswiderstand im Trabekelmaschenwerk haben. Interessanterweise konnten auch ver\u00e4nderte Level von Spurenelementen, wie Zink oder Selen, im Kammerwasser von Glaukompatienten detektiert werden. Die erh\u00f6hten Zinkwerte k\u00f6nnten am Ungleichgewicht der Matrixmetalloproteinasen im Auge beteiligt und somit f\u00fcr einen erh\u00f6hten Augeninnendruck verantwortlich sein. All diese Studien zeigen die komplexen Kammerwasserver\u00e4nderungen beim Glaukom auf. M\u00f6glicherweise kann ein Teil dieser Biomarker zuk\u00fcnftig zur Fr\u00fcherkennung der Erkrankung herangezogen werden.<\/jats:p>","DOI":"10.1055\/a-1690-7468","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T01:23:22Z","timestamp":1645752202000},"page":"169-176","source":"Crossref","is-referenced-by-count":6,"title":["Spezifische Biomarker im Kammerwasser von Glaukompatienten"],"prefix":"10.1055","volume":"239","author":[{"given":"Sabrina","family":"Reinehr","sequence":"additional","affiliation":[{"name":"Experimental Eye Research Institute, Ruhr-Universit\u00e4t Bochum, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Mueller-Buehl","sequence":"additional","affiliation":[{"name":"Experimental Eye Research Institute, Ruhr-Universit\u00e4t Bochum, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Tsai","sequence":"additional","affiliation":[{"name":"Experimental Eye Research Institute, Ruhr-Universit\u00e4t Bochum, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-0829","authenticated-orcid":false,"given":"Stephanie C.","family":"Joachim","sequence":"additional","affiliation":[{"name":"Experimental Eye Research Institute, Ruhr-Universit\u00e4t Bochum, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/s0161-6420(98)92665-3","article-title":"Prevalence of glaucoma and intraocular pressure distribution in a defined population. 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