{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:44Z","timestamp":1740126824845,"version":"3.37.3"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>\n            Background\u2003Before the advent of antenatal steroids, early non-invasive respiratory support (NIV), and intratracheal surfactant, antenatal terbutaline was also used to improve lung compliance and reduce the incidence of respiratory distress syndrome (RDS).<\/jats:p><jats:p>\n            Objectives\u2003The objective of this paper was to study the association between antenatal terbutaline and endotracheal intubation (ET) within the first 24\u2009hours of life, RDS, bronchopulmonary dysplasia (BPD), and intraventricular hemorrhage (IVH) in infants with the gestational age (GA) of &lt;32 weeks, and to study the association between antenatal terbutaline, and ET or NIV within the first 24\u2009hours of life, and RDS in infants with the GA of 32 to 36 weeks.<\/jats:p><jats:p>\n            Method\u2003This was a retrospective medical record review of preterm infants delivered at a single tertiary care center from October 2016 to December 2020. Multivariable logistic regression was used to explore the association between antenatal terbutaline and neonatal respiratory support.<\/jats:p><jats:p>\n            Result\u20031,794 infants were included, 234 (13.0%) had the GA of &lt;32 weeks and 1,560 (86.9%) had the GA of 32 to 36 weeks. Antenatal terbutaline, corticosteroid, or both agents were administered in 561 (31.3%), 1,461 (81.4%), and 555 (30.9%), respectively. Antenatal terbutaline was significantly associated with a reduction in ET (adjusted odds ratio [aOR]\u2009=\u20090.40, 95% confident interval [CI] 0.19\u20130.82, p\u2009=\u20090.012) in infants with the GA of &lt;32 weeks, but not in infants with the GA of 32\u201336 weeks. Antenatal terbutaline was not associated with RDS or BPD but was significantly associated with a reduction in grade III-IV IVH (aOR 0.11, CI 0.01\u20130.98; p\u2009=\u20090.048), in infants with the GA of &lt;32 weeks.<\/jats:p><jats:p>\n            Conclusion\u2003In a state-of-the-art neonatal care setting, antenatal terbutaline was associated with a reduction in ET during the first 24\u2009hours in infants with the GA of &lt;32 weeks. The use of antenatal terbutaline to improve acute neonatal respiratory outcomes merits reconsideration.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1695-8220","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T23:50:31Z","timestamp":1636761031000},"page":"478-487","source":"Crossref","is-referenced-by-count":0,"title":["Association of Antenatal Terbutaline and Respiratory Support Requirements in Preterm Neonates"],"prefix":"10.1055","volume":"41","author":[{"given":"Visanu","family":"Kittiarpornpon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Perinatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pitiporn","family":"Siripattanapipong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Perinatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walaiporn","family":"Bowornkitiwong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Perinatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratchada","family":"Kitsommart","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Perinatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sopapan","family":"Ngerncham","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Perinatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pimol","family":"Wongsiridach","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Perinatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1611-0170","authenticated-orcid":false,"given":"Buranee","family":"Yangthara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology and Perinatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jpeds.2018.01.043","article-title":"Bronchopulmonary dysplasia: executive summary of a workshop","volume":"197","author":"R 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