{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:54:46Z","timestamp":1788184486287,"version":"build-2803163510"},"reference-count":58,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"crossref","award":["MOST 108\u20132314-B-002\u2013088-MY3"],"award-info":[{"award-number":["MOST 108\u20132314-B-002\u2013088-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"crossref","award":["MOST 108\u20132320-B-038\u2013057-MY3"],"award-info":[{"award-number":["MOST 108\u20132320-B-038\u2013057-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"crossref","award":["MOST 110\u20132320-B-002-064"],"award-info":[{"award-number":["MOST 110\u20132320-B-002-064"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Formation of intravenous catheter-related thrombosis leads to central venous stenosis in patients requiring renal replacement therapy or chemotherapy infusion, yet the triggers or mechanisms remain unclear, especially in patients without symptoms of infection. In this study, we found that neutrophil extracellular traps (NETs) could be detected in the fibrin sheaths from dialysis patients without clinical manifestations of infection. Confocal microscopy revealed bacteria imbedded in NETs in the fibrin sheaths. Thirty-nine of 50 (78%) fibrin sheath specimens contained bacteria detectable by 16S ribosomal RNA genome typing with a predominance of Staphylococcus aureus (69%). In rat models, transient bacteremia of S. aureus induced NETs in enlarged fibrin sheaths, and treatment with DNase I alone significantly reduced both NET and fibrin sheath formation surrounding the catheter. Therefore, transient bacteremia could be a silent trigger that induces NET-related immunothrombosis enhancing catheter-related central venous stenosis.<\/jats:p>","DOI":"10.1055\/a-1695-8612","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T23:49:52Z","timestamp":1636760992000},"page":"1198-1208","source":"Crossref","is-referenced-by-count":8,"title":["Transient Bacteremia Promotes Catheter-Related Central Venous Thrombosis through Neutrophil Extracellular Traps"],"prefix":"10.1055","volume":"122","author":[{"given":"Jeng-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Department of Surgery, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chieh","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan"},{"name":"Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chia","family":"Su","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan"},{"name":"Department of ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron-Bin","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Department of Surgery, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Ling","family":"Chiu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan"},{"name":"Division of Nephrology, Department of Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan"},{"name":"Graduate Program in Biomedical Informatics, Department of Computer Science and Engineering, College of Informatics, Yuan Ze University, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7824-3454","authenticated-orcid":false,"given":"Chiau-Jing","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-San","family":"Chia","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan"},{"name":"Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan"},{"name":"Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/infdis\/jis021","article-title":"Platelets enhance biofilm formation and resistance of endocarditis-inducing streptococci on the injured heart valve","volume":"205","author":"C J Jung","year":"2012","journal-title":"J Infect Dis"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1055\/s-0039-1678665","article-title":"Neutrophil extracellular traps enhance Staphylococcus Aureus vegetation formation through interaction with platelets in infective endocarditis","volume":"119","author":"C C Hsu","year":"2019","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1161\/CIRCULATIONAHA.114.011432","article-title":"Endocarditis pathogen promotes vegetation formation by inducing intravascular neutrophil extracellular traps through activated platelets","volume":"131","author":"C J Jung","year":"2015","journal-title":"Circulation"},{"issue":"01","key":"ref4","first-page":"43","article-title":"The development of fibrin sheath on indwelling venous catheters","volume":"137","author":"W R Peters","year":"1973","journal-title":"Surg Gynecol Obstet"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/sdi.12074","article-title":"Fibrin sheath and its relation to subsequent events after tunneled dialysis catheter exchange","volume":"26","author":"A Shanaah","year":"2013","journal-title":"Semin Dial"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1001\/archsurg.1971.01350040115023","article-title":"Fibrin sleeve formation on indwelling subclavian central venous catheters","volume":"102","author":"V L Hoshal Jr","year":"1971","journal-title":"Arch Surg"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.2214\/ajr.168.5.9129419","article-title":"Placement of long-term central venous catheters in outpatients: study of 134 patients over 24,596 catheter days","volume":"168","author":"B Damascelli","year":"1997","journal-title":"AJR Am J Roentgenol"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1051-0443(94)71522-0","article-title":"Fibrin sheath entrapment of peripherally inserted central catheters","volume":"5","author":"J F Cardella","year":"1994","journal-title":"J Vasc Interv Radiol"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1053\/j.tvir.2008.09.008","article-title":"Malfunction of dialysis catheters: management of fibrin sheath and related problems","volume":"11","author":"S Faintuch","year":"2008","journal-title":"Tech Vasc Interv Radiol"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1053\/j.ajkd.2012.10.024","article-title":"Central vein stenosis","volume":"61","author":"A K Agarwal","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1097\/01.RVI.0000086531.86489.4C","article-title":"Histologic changes in the human vein wall adjacent to indwelling central venous catheters","volume":"14","author":"A R Forauer","year":"2003","journal-title":"J Vasc Interv Radiol"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1148\/radiol.2402031129","article-title":"Jugular vein catheter placement: histologic features and development of catheter-related (fibrin) sheaths in a swine model","volume":"240","author":"A R Forauer","year":"2006","journal-title":"Radiology"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.jpedsurg.2015.04.019","article-title":"Histological changes of the unligated vein wall adjacent to the central venous catheter after open cutdown in rats","volume":"50","author":"S Kim","year":"2015","journal-title":"J Pediatr Surg"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0741-5214(98)70162-4","article-title":"Composition and formation of the sleeve enveloping a central venous catheter","volume":"28","author":"D Z Xiang","year":"1998","journal-title":"J Vasc Surg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2152\/jmi.66.148","article-title":"Bacterial contamination of hemodialysis devices in hospital dialysis wards","volume":"66","author":"T Shimohata","year":"2019","journal-title":"J Med Invest"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/599376","article-title":"Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America","volume":"49","author":"L A Mermel","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0008-6363(02)00857-X","article-title":"Infection and inflammation and the coagulation system","volume":"60","author":"M Levi","year":"2003","journal-title":"Cardiovasc Res"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/nchembio.124","article-title":"Spatial localization of bacteria controls coagulation of human blood by \u2018quorum acting\u2019","volume":"4","author":"C J Kastrup","year":"2008","journal-title":"Nat Chem Biol"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.4049\/jimmunol.1000675","article-title":"A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus","volume":"185","author":"F H Pilsczek","year":"2010","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"V Brinkmann","year":"2004","journal-title":"Science"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"B Engelmann","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"V Papayannopoulos","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"08","key":"ref23","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1128\/AEM.02272-07","article-title":"Critical evaluation of two primers commonly used for amplification of bacterial 16S rRNA genes","volume":"74","author":"J A Frank","year":"2008","journal-title":"Appl Environ Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13104-016-1902-0","article-title":"An optimized staining technique for the detection of Gram positive and Gram negative bacteria within tissue","volume":"9","author":"S C Becerra","year":"2016","journal-title":"BMC Res Notes"},{"issue":"02","key":"ref25","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.mimet.2007.02.005","article-title":"A detailed analysis of 16S ribosomal RNA gene segments for the diagnosis of pathogenic bacteria","volume":"69","author":"S Chakravorty","year":"2007","journal-title":"J Microbiol Methods"},{"issue":"08","key":"ref26","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1681\/ASN.V981507","article-title":"Subclavian vascular access stenosis in dialysis patients: natural history and risk factors","volume":"9","author":"D Hern\u00e1ndez","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mimet.2016.06.027","article-title":"Use of MALDI-TOF to detect colonized vascular catheter tips after 6 and 12h of incubation","volume":"128","author":"E Bouza","year":"2016","journal-title":"J Microbiol Methods"},{"issue":"04","key":"ref28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/sdi.12360","article-title":"Bacterial colonization of thrombosed dialysis arteriovenous grafts","volume":"28","author":"G A Beathard","year":"2015","journal-title":"Semin Dial"},{"issue":"09","key":"ref29","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrmicro3521","article-title":"Staphylococcal manipulation of host immune responses","volume":"13","author":"V Thammavongsa","year":"2015","journal-title":"Nat Rev Microbiol"},{"issue":"03","key":"ref30","doi-asserted-by":"crossref","first-page":"480","DOI":"10.4161\/hv.23223","article-title":"Capsular polysaccharides are an important immune evasion mechanism for Staphylococcus aureus","volume":"9","author":"J S Nanra","year":"2013","journal-title":"Hum Vaccin Immunother"},{"issue":"04","key":"ref31","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.cub.2005.12.039","article-title":"DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps","volume":"16","author":"J T Buchanan","year":"2006","journal-title":"Curr Biol"},{"issue":"06","key":"ref32","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1128\/IAI.00051-08","article-title":"Beta-hydroxybutyrate abrogates formation of bovine neutrophil extracellular traps and bactericidal activity against mammary pathogenic Escherichia coli","volume":"76","author":"N Grinberg","year":"2008","journal-title":"Infect Immun"},{"issue":"09","key":"ref33","doi-asserted-by":"crossref","first-page":"e23637","DOI":"10.1371\/journal.pone.0023637","article-title":"Neutrophil extracellular trap (NET)-mediated killing of Pseudomonas aeruginosa: evidence of acquired resistance within the CF airway, independent of CFTR","volume":"6","author":"R L Young","year":"2011","journal-title":"PLoS One"},{"issue":"03","key":"ref34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000205937","article-title":"Survival of bacterial biofilms within neutrophil extracellular traps promotes nontypeable Haemophilus influenzae persistence in the chinchilla model for otitis media","volume":"1","author":"W Hong","year":"2009","journal-title":"J Innate Immun"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1189\/jlb.3A0415-161R","article-title":"Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets","volume":"99","author":"A Carestia","year":"2016","journal-title":"J Leukoc Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3389\/fcimb.2019.00106","article-title":"The complex fibrinogen interactions of the Staphylococcus aureus coagulases","volume":"9","author":"S Thomas","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"issue":"01","key":"ref37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrmicro3161","article-title":"Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus","volume":"12","author":"T J Foster","year":"2014","journal-title":"Nat Rev Microbiol"},{"issue":"02","key":"ref38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000333447","article-title":"Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections","volume":"4","author":"M McAdow","year":"2012","journal-title":"J Innate Immun"},{"issue":"08","key":"ref39","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1086\/501366","article-title":"The role of Staphylococcus aureus adhesins in the pathogenesis of ventricular assist device-related infections","volume":"193","author":"C Arrecubieta","year":"2006","journal-title":"J Infect Dis"},{"issue":"03","key":"ref40","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1160\/TH08-06-0395","article-title":"Contribution of (sub)domains of Staphylococcus aureus fibronectin-binding protein to the proinflammatory and procoagulant response of human vascular endothelial cells","volume":"101","author":"R Heying","year":"2009","journal-title":"Thromb Haemost"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1084\/jem.20050125","article-title":"Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis","volume":"201","author":"Y A Que","year":"2005","journal-title":"J Exp Med"},{"issue":"06","key":"ref42","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1128\/AAC.44.6.1549-1555.2000","article-title":"A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus","volume":"44","author":"Y Katayama","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"issue":"04","key":"ref43","doi-asserted-by":"crossref","first-page":"e1002626","DOI":"10.1371\/journal.ppat.1002626","article-title":"Methicillin resistance alters the biofilm phenotype and attenuates virulence in Staphylococcus aureus device-associated infections","volume":"8","author":"C Pozzi","year":"2012","journal-title":"PLoS Pathog"},{"issue":"05","key":"ref44","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/infdis\/jir845","article-title":"Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system","volume":"205","author":"J K Rudkin","year":"2012","journal-title":"J Infect Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2015.00001","article-title":"Methicillin resistance and the biofilm phenotype in Staphylococcus aureus","volume":"5","author":"H McCarthy","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"issue":"09","key":"ref46","doi-asserted-by":"crossref","first-page":"e0137550","DOI":"10.1371\/journal.pone.0137550","article-title":"Neutrophil responses to sterile implant materials","volume":"10","author":"S Jhunjhunwala","year":"2015","journal-title":"PLoS One"},{"issue":"01","key":"ref47","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/rb\/rbw041","article-title":"An overview of the role of neutrophils in innate immunity, inflammation and host-biomaterial integration","volume":"4","author":"G S Selders","year":"2017","journal-title":"Regen Biomater"},{"issue":"05","key":"ref48","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.kint.2018.11.046","article-title":"Innovations in vascular access for hemodialysis","volume":"95","author":"A K Agarwal","year":"2019","journal-title":"Kidney Int"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40169-015-0050-9","article-title":"An engineered micropattern to reduce bacterial colonization, platelet adhesion and fibrin sheath formation for improved biocompatibility of central venous catheters","volume":"4","author":"R M May","year":"2015","journal-title":"Clin Transl Med"},{"issue":"08","key":"ref50","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1161\/ATVBAHA.118.311150","article-title":"Neutrophil extracellular traps induce endothelial cell activation and tissue factor production through interleukin-1\u03b1 and cathepsin G","volume":"38","author":"E J Folco","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"03","key":"ref51","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00441-017-2785-7","article-title":"Neutrophils in tissue injury and repair","volume":"371","author":"J Wang","year":"2018","journal-title":"Cell Tissue Res"},{"issue":"10","key":"ref52","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1161\/ATVBAHA.116.307634","article-title":"Neutrophil extracellular traps promote angiogenesis: evidence from vascular pathology in pulmonary hypertension","volume":"36","author":"L Aldabbous","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"05","key":"ref53","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1097\/01.CCM.0000215832.40827.71","article-title":"Enoxaparin inhibits fibrin sheath formation and decreases central venous catheter colonization following bacteremic challenge","volume":"34","author":"J E Keller","year":"2006","journal-title":"Crit Care Med"},{"issue":"01","key":"ref54","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13054-016-1585-x","article-title":"Normal saline versus heparin for patency of central venous catheters in adult patients - a systematic review and meta-analysis","volume":"21","author":"L Zhong","year":"2017","journal-title":"Crit Care"},{"issue":"02","key":"ref55","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1023\/A:1011272632286","article-title":"Thrombolysis for restoration of patency to haemodialysis central venous catheters: a systematic review","volume":"11","author":"C M Clase","year":"2001","journal-title":"J Thromb Thrombolysis"},{"issue":"02","key":"ref56","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4174\/astr.2017.92.2.97","article-title":"Inhibitory effect of sustained perivascular delivery of paclitaxel on neointimal hyperplasia in the jugular vein after open cutdown central venous catheter placement in rats","volume":"92","author":"S Kim","year":"2017","journal-title":"Ann Surg Treat Res"},{"issue":"24","key":"ref57","doi-asserted-by":"crossref","first-page":"e011245","DOI":"10.1161\/JAHA.118.011245","article-title":"Risk of death following application of paclitaxel-coated balloons and stents in the femoropopliteal artery of the leg: a systematic review and meta-analysis of randomized controlled trials","volume":"7","author":"K Katsanos","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.actbio.2016.08.010","article-title":"Co-immobilization of palm and DNase I for the development of an effective anti-infective coating for catheter surfaces","volume":"44","author":"D Alves","year":"2016","journal-title":"Acta Biomater"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1695-8612.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T15:38:12Z","timestamp":1699803492000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1695-8612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,12]]},"references-count":58,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2022,8,17]]},"published-print":{"date-parts":[[2022,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1695-8612","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,11,12]]},"published":{"date-parts":[[2021,11,12]]}}}