{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:11:11Z","timestamp":1777104671752,"version":"3.51.4"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glial heterotopia (GH) is the presence of glial tissue outside the cranial cavity, without communication with the brain. The orbital location usually presents as eyelid swelling,\n          strabismus, and proptosis. This is considered a congenital location that usually presents at birth. Its association with anophthalmia is uncommon. We report the case of a 2-day-old male\n          neonate with left congenital intraorbital lesion presenting with massive proptosis. No eyeball could be seen. Preoperative magnetic resonance imaging disclosed a large and predominantly\n          cystic mass occupying and protruding from the left orbit without intracranial extension. In the operating theatre, a large amount of fluid was aspirated prior to total resection of the mass.\n          Chemical analysis of the fluid was compatible with cerebrospinal fluid. Histologically, the tumor was composed of mature neuroglial tissue and ependymal cells. Despite multiple sections, no\n          choroid plexus or intraocular content was found. The diagnosis of GH with anophthalmia was made.<\/jats:p>","DOI":"10.1055\/a-1699-2758","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T07:04:45Z","timestamp":1646636685000},"page":"1103-1106","source":"Crossref","is-referenced-by-count":2,"title":["Congenital Orbital Glial Heterotopia Associated with Clinicopathological Anophthalmia: A Case Report"],"prefix":"10.1055","volume":"240","author":[{"given":"Natalia","family":"Reyes-Godinez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Northeast National Medical Center, Instituto Mexicano del Seguro Social, Monterrey, Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica E.","family":"Tamez-Tamez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Northeast National Medical Center, Instituto Mexicano del Seguro Social, Monterrey, Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7022-2395","authenticated-orcid":false,"given":"Raul E.","family":"Ruiz-Lozano","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephania","family":"Chavez-Cobian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Northeast National Medical Center, Instituto Mexicano del Seguro Social, Monterrey, Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Gonzalez-Murillo","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, Northeast National Medical Center, Instituto Mexicano del Seguro Social, Monterrey, Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauro Arturo","family":"Villarreal-Reyes","sequence":"additional","affiliation":[{"name":"Department of Orbit and Oculoplastics, Northeast National Medical Center, Instituto Mexicano del Seguro Social, Monterrey, Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/01676839209101204","article-title":"Disjunct cephalocele (bilateral orbital cystic glial tissue): A clinico-pathologic entity","volume":"11","author":"A M Nasr","year":"1992","journal-title":"Orbit"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1001\/archopht.1987.01060030110038","article-title":"Heterotopic brain tissue in the orbit","volume":"105","author":"R B Wilkins","year":"1987","journal-title":"Arch Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/IOP.0000000000001425","article-title":"Orbital Glial Heterotopia: A Report of 2 Cases and Review of the Literature","volume":"36","author":"N S Mehta","year":"2020","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/S0022-3468(97)90319-5","article-title":"Prenatal diagnosis of orbital heterotopic brain tissue","volume":"32","author":"M Hingorani","year":"1997","journal-title":"J Pediatr Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/eye.1999.61","article-title":"Ectopic brain tissue in the orbit","volume":"13","author":"A J Scheiner","year":"1999","journal-title":"Eye (Lond)"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3928\/15428877-20070301-10","article-title":"Clinical anophthalmia with orbital heterotopic brain tissue","volume":"38","author":"A K Grover","year":"2007","journal-title":"Ophthalmic Surg Lasers Imaging"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.survophthal.2004.02.001","article-title":"Orbital cysts of childhood\u2013classification, clinical features, and management","volume":"49","author":"J A Shields","year":"2004","journal-title":"Surv Ophthalmol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jaapos.2019.07.010","article-title":"Orbital conjunctival epithelial cyst mimicking cyst with microphthalmos","volume":"23","author":"R Mittal","year":"2019","journal-title":"J AAPOS"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1097\/IOP.0000000000001092","article-title":"Nasal Glioma: A Rare Cause of Congenital Inner Canthal Swelling","volume":"34","author":"N C Charles","year":"2018","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1007\/s00381-016-3107-1","article-title":"Glial heterotopia of the orbit: a rare cause of proptosis","volume":"32","author":"S Bakhti","year":"2016","journal-title":"Childs Nerv Syst"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1001\/archopht.1980.01020030711013","article-title":"Cerebellar heterotopia in the orbit","volume":"98","author":"N B Call","year":"1980","journal-title":"Arch Ophthalmol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20091019-08","article-title":"Simultaneous Occurrence of Glial Heterotopia and Meningocele in the Orbit with Clinical Anophthalmia and Neurological Anomalies","author":"N Pushker","year":"2009","journal-title":"J Pediatr Ophthalmol Strabismus"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1699-2758.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:22:52Z","timestamp":1693869772000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1699-2758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,4]]},"references-count":12,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2023,9,4]]},"published-print":{"date-parts":[[2023,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1699-2758","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,4]]}}}