{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T17:26:00Z","timestamp":1649093160247},"reference-count":64,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Neben dem Kammerwasser und dem Blut spielt auch der Liquor cerebrospinalis eine wesentliche Rolle in der Pathophysiologie des prim\u00e4ren Offenwinkelglaukoms (POWG) und insbesondere auch beim\n\t\t\t\t\tNormaldruckglaukom (NDG). Neben dem Liquordruck, der eine wichtige Rolle bei der Stauungspapille spielt, ist vor allem die Zusammensetzung des Liquors sowie die Flie\u00dfgeschwindigkeit von\n\t\t\t\t\tBedeutung. Der Liquor steht sowohl mit dem Gehirn, dem Spinalkanal als auch mit dem Sehnerv im Kontakt. Bei neurodegenerativen Erkrankungen wird neben einer ver\u00e4nderten Zusammensetzung des\n\t\t\t\t\tLiquors auch ein eine verlangsamte Flussgeschwindigkeit als m\u00f6glicher pathophysiologischer Faktor beschrieben. Auch im perioptischen Subarachnoidalraum des Sehnervs sind bei Patienten mit\n\t\t\t\t\tNormaldruckglaukom Ver\u00e4nderungen der Liquorzusammensetzung wie auch der Flussgeschwindigkeit beschrieben. Diese Befunde legen nahe, dass es sich beim prim\u00e4ren POWG, insbesondere aber beim\n\t\t\t\t\tNDG um einen neurodegenerativen Prozess handeln kann.<\/jats:p>","DOI":"10.1055\/a-1699-2911","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T01:23:22Z","timestamp":1645752202000},"page":"177-181","source":"Crossref","is-referenced-by-count":0,"title":["Zerebrale und liquorspezifische Besonderheiten beim prim\u00e4ren Offenwinkelglaukom und Normaldruckglaukom"],"prefix":"10.1055","volume":"239","author":[{"given":"Hanspeter Esriel","family":"Killer","sequence":"additional","affiliation":[{"name":"Departement Biomedizin, Universit\u00e4t Basel, Schweiz"},{"name":"Augen\u00e4rztezentrum Aarau, Aarau, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0161-6420(92)31774-9","article-title":"Prevalence of glaucoma. The Beaver Dam Eye Study","volume":"99","author":"B E Klein","year":"1992","journal-title":"Ophthalmology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.survophthal.2013.09.003","article-title":"Population-based glaucoma prevalence studies in Asians","volume":"5","author":"H K Cho","year":"2014","journal-title":"Surv Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1001\/archopht.1985.01050080057020","article-title":"Comparison of the optic nerve head in high- and low-tension glaucoma","volume":"103","author":"J Caprioli","year":"1985","journal-title":"Arch Ophthalmol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.survophthal.2013.09.003","article-title":"Population-based glaucoma prevalence studies in Asians","volume":"59","author":"H K Cho","year":"2014","journal-title":"Surv Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/s41433-018-0042-2","article-title":"Normal tension glaucoma: review of the current understanding and mechanisms of the pathogenesis","volume":"32","author":"H E Killer","year":"2018","journal-title":"Eye (Lond)"},{"key":"ref6","first-page":"1563","article-title":"The current research status of normal tension glaucoma","volume":"9","author":"X S Mi","year":"2014","journal-title":"Clin Interv Aging"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/bs.pbr.2015.05.007","article-title":"Advance in the pathogenesis and treatment of normal-tension glaucoma","volume":"221","author":"R Mastropasqua","year":"2015","journal-title":"Prog Brain Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4103\/2008-322X.183914","article-title":"Update on normal tension glaucoma","volume":"11","author":"J Mallick","year":"2016","journal-title":"J Ophthalmic Vis Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0002-9394(98)00272-4","article-title":"The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma","volume":"126","author":"Collaborative Normal-Tension Glaucoma Study Group","year":"1998","journal-title":"Am J Ophthalmol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1350-9462(02)00008-3","article-title":"The impact of ocular blood flow in glaucoma","volume":"21","author":"J Flammer","year":"2002","journal-title":"Prog Retin Eye Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/0039-6257(94)90041-8","article-title":"The vascular concept of glaucoma","volume":"38","author":"J Flammer","year":"1994","journal-title":"Surv Ophthalmol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.survophthal.2006.02.008","article-title":"A sick eye in a sick body? Systemic findings in patients with primary open angle glaucoma","volume":"51","author":"M Pache","year":"2006","journal-title":"Surv Ophthalmol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s13167-017-0090-x","article-title":"The discovery of the Flammer syndrome: a historical and personal perspective","volume":"8","author":"J Flammer","year":"2017","journal-title":"EPMA J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e0165314","DOI":"10.1371\/journal.pone.0165314","article-title":"Changes to the aqueous humor proteome during glaucoma","volume":"11","author":"M A Kaeslin","year":"2016","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/IJG.0b013e31826a7dea","article-title":"Lipocalin-like prostaglandin D synthase (L-PGDS) concentration in aqueous humour in patients with open-angle glaucoma","volume":"23","author":"G Bauer","year":"2014","journal-title":"J Glaucoma"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/bjo.87.6.777","article-title":"Architecture of arachnoid trabeculae, pillars, and septa in the subarachnoid space of the human optic nerve: anatomy and clinical considerations","volume":"87","author":"H E Killer","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"ref17","first-page":"54","article-title":"Cerebrospinal fluid stasis and its clinical significance","volume":"15","author":"J M Whedon","year":"2009","journal-title":"Altern Ther Health Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S1474-4422(03)00487-3","article-title":"Alzheimer\u02bcs disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis","volume":"2","author":"G D Silverberg","year":"2003","journal-title":"Lancet Neurol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ajo.2013.03.003","article-title":"Senescent changes in cerebrospinal fluid circulatory physiology and their role in the pathogenesis of normal-tension glaucoma","volume":"156","author":"P Wostyn","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1167\/iovs.14-15041","article-title":"Glaucoma considered as an imbalance between production and clearance of neurotoxins","volume":"55","author":"P Wostyn","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/brain\/awl045","article-title":"The optic nerve: a new window into cerebrospinal fluid composition?","volume":"129","author":"H E Killer","year":"2006","journal-title":"Brain"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1167\/iovs.08-2228","article-title":"Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study","volume":"49","author":"J P Berdahl","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.ophtha.2008.01.013","article-title":"Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma","volume":"115","author":"J P Berdahl","year":"2008","journal-title":"Ophthalmology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/APO.0000000000000170","article-title":"Translamina cribrosa pressure difference as potential element in the pathogenesis of glaucomatous optic neuropathy","volume":"5","author":"J B Jonas","year":"2016","journal-title":"Asia Pac J Ophthalmol 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Ren","year":"2010","journal-title":"Ophthalmology"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e52664","DOI":"10.1371\/journal.pone.0052664","article-title":"Cerebrospinal fluid pressure decreases with older age","volume":"7","author":"D Fleischman","year":"2012","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ophtha.2017.09.022","article-title":"Normal-tension glaucoma has normal intracranial pressure: a prospective study of intracranial pressure and intraocular pressure in different body positions","volume":"125","author":"C Linden","year":"2018","journal-title":"Ophthalmology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e524","DOI":"10.1111\/aos.13302","article-title":"Translaminar pressure in Caucasian normal tension glaucoma patients","volume":"95","author":"A Pircher","year":"2017","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/eye.2015.223","article-title":"TLP: a premature concept","volume":"30","author":"A Pircher","year":"2016","journal-title":"Eye (Lond)"},{"key":"ref32","volume-title":"Physiology of the cerebrospinal Fluid","author":"H Davson","year":"1967"},{"key":"ref33","volume-title":"Physiology and Pathophysiology of the cerebrospinal Fluid","author":"H Davson","year":"1987"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/204290a0","article-title":"Movement of the cerebrospinal fluid in human beings","volume":"204","author":"G Dichiro","year":"1964","journal-title":"Nature"},{"key":"ref35","first-page":"3152","article-title":"In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR) Mol Cell","volume":"13","author":"A Guldbrandsen","year":"2014","journal-title":"Proteomics"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"34 (2018)","DOI":"10.1186\/s12987-018-0120-7","article-title":"Choroid plexus genes for CSF production and brain homeostasis are altered in Alzheimer\u02bcs disease","volume":"15","author":"S Kant","year":"2018","journal-title":"Fluids Barriers CNS"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/hbm.23862","article-title":"Diffuse brain damage in normal tension glaucoma","volume":"39","author":"A Giorgio","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"ref38","first-page":"1","article-title":"Glaucoma may be a non-memory manifestation of Alzheimer\u02bcs disease in older people","volume":"29","author":"S W Lai","year":"2017","journal-title":"Int Psychogeriatr"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/IJG.0b013e31802b3527","article-title":"No increased risk of developing Alzheimer disease in patients with glaucoma","volume":"16","author":"L V Kessing","year":"2007","journal-title":"J Glaucoma"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000047976","article-title":"High occurrence rate of glaucoma among patients with Alzheimer\u02bcs disease","volume":"47","author":"A U Bayer","year":"2002","journal-title":"Eur Neurol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jns.2006.02.009","article-title":"High frequency of open-angle glaucoma in Japanese patients with Alzheimer\u02bcs disease","volume":"246","author":"H Tamura","year":"2006","journal-title":"J Neurol Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1755-3768.2011.02125.x","article-title":"Normal tension glaucoma and Alzheimer disease: comorbidity?","volume":"90","author":"D Bach-Holm","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1212\/WNL.57.10.1763","article-title":"The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer\u02bcs type","volume":"57","author":"G D Silverberg","year":"2001","journal-title":"Neurology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fnagi.2019.00087","article-title":"Decreased Cerebrospinal Fluid Flow Is Associated with Cognitive Deficit in Elderly Patients","volume":"11","author":"J Attier-Zmudka","year":"2019","journal-title":"Front Aging Neurosci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/ceo.13116","article-title":"Flow dynamics of cerebrospinal fluid between the intracranial cavity and the subarachnoid space of the optic nerve measured with a diffusion magnetic resonance imaging sequence in patients\n\t\t\t\t\twith normal tension glaucoma","volume":"46","author":"D Boye","year":"2018","journal-title":"Clin Exp Ophthalmol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/1073858418775027","article-title":"Fluid Dynamics Inside the Brain Barrier: Current Concept of Interstitial Flow, Glymphatic Flow, and Cerebrospinal Fluid Circulation in the Brain","volume":"25","author":"T Nakada","year":"2019","journal-title":"Neuroscientist"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/00041327-199912000-00002","article-title":"Lymphatic capillaries in the meninges of the human optic nerve","volume":"19","author":"H E Killer","year":"1999","journal-title":"J Neuroophthalmol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1369\/jhc.2008.950840","article-title":"Does immunohistochemistry allow easy detection of lymphatics in the optic nerve sheath?","volume":"56","author":"H E Killer","year":"2008","journal-title":"J Histochem Cytochem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/brain\/awl324","article-title":"Cerebrospinal fluid dynamics between the intracranial and the subarachnoid space of the optic nerve. Is it always bidirectional?","volume":"130","author":"H E Killer","year":"2007","journal-title":"Brain"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1136\/bjophthalmol-2011-300663","article-title":"Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma","volume":"96","author":"H E Killer","year":"2012","journal-title":"Br J Ophthalmol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2147\/EB.S297274","article-title":"Lipocalin-type Prostaglandin D Synthase Concentration Gradients in the Cerebrospinal Fluid in Normal-tension Glaucoma Patients with Optic Nerve Sheath Compartmentation","volume":"13","author":"A Pircher","year":"2021","journal-title":"Eye Brain"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0009-8981(01)00573-3","article-title":"Dynamics of brain-derived proteins in cerebrospinal fluid","volume":"310","author":"H Reiber","year":"2001","journal-title":"Clin Chim Acta"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/ana.410440606","article-title":"Beta-trace protein in cerebrospinal fluid: a blood-CSF barrier-related evaluation in neurological diseases","volume":"44","author":"H Tumani","year":"1998","journal-title":"Ann Neurol"},{"key":"ref54","first-page":"166","article-title":"Prostaglandin D2 synthase: apoptotic factor in alzheimer plasma, inducer of reactive oxygen species, inflammatory cytokines and dialysis dementia","volume":"2","author":"J K Maesaka","year":"2013","journal-title":"J Nephropathol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1097\/00001756-200108280-00008","article-title":"Prostaglandin D2 synthase induces apoptosis in PC12 neuronal cells","volume":"12","author":"L Ragolia","year":"2001","journal-title":"Neuroreport"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-0404.1972.tb07527.x","article-title":"Beta-trace protein concentration in CSF in neurological disorders","volume":"48","author":"H Link","year":"1972","journal-title":"Acta Neurol Scand"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/bjo.2009.171660","article-title":"Cerebrospinal fluid segregation optic neuropathy: an experimental model and a hypothesis","volume":"94","author":"G P Jaggi","year":"2010","journal-title":"Br J Ophthalmol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/bjo.83.2.231","article-title":"Histochemical localisation of mitochondrial enzyme activity in human optic nerve and retina","volume":"83","author":"R M Andrews","year":"1999","journal-title":"Br J Ophthalmol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fneur.2017.00047","article-title":"The optic canal: a bottleneck for cerebrospinal fluid dynamics in normal-tension glaucoma?","volume":"8","author":"A Pircher","year":"2017","journal-title":"Front Neurol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1167\/iovs.17-22290","article-title":"Evidence for Cerebrospinal Fluid Entry Into the Optic Nerve via a Glymphatic Pathway","volume":"58","author":"E Mathieu","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1167\/iovs.17-23119","article-title":"The First Histologic Evidence of a Paravascular Pathway Within the Optic Nerve","volume":"59","author":"P Wostyn","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/j.ophtha.2011.06.021","article-title":"Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight","volume":"118","author":"T H 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