{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:41:54Z","timestamp":1654648914697},"reference-count":48,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Volkskrankheit \u201ebenignes Prostatasyndrom\u201c erfordert mit der Vielzahl an betroffenen M\u00e4nnern und einer variablen klinischen Pr\u00e4sentation individuelle Therapieoptionen, die auf die jeweiligen klinischen Charakteristika und W\u00fcnsche des Patienten zugeschnitten werden. Ist eine operative Therapie indiziert, steht ein gro\u00dfes Spektrum an invasiven Verfahren zur Verf\u00fcgung. Als Goldstandard galten lange Zeit die transurethrale Resektion der Prostata und die offene Adenomenukleation, die jedoch mit erh\u00f6hter Morbidit\u00e4t und Einschr\u00e4nkungen der Sexualfunktion einhergehen. Daher wird zunehmend nach minimal-invasiven Therapieoptionen gefordert, die eine effektive und sichere Therapie im ambulanten Setting erm\u00f6glichen sollen. \u00dcber die letzten Jahre wurde eine Vielzahl an Technologien und Verfahren entwickelt und getestet, von denen nur wenige in der klinischen Praxis etabliert werden konnten, meist aufgrund unzureichender funktioneller Ergebnisse. Nicht mehr empfohlen werden daher die transurethrale Nadelablation, transurethrale Mikrowellentherapie, intraprostatische Botulinumtoxin-A- oder PRX302-Injektionen und prostatische Stents. Demgegen\u00fcber spricht die Europ\u00e4ische Gesellschaft f\u00fcr Urologie derzeit Empfehlungen f\u00fcr den UroLift, die Aquablation und die Prostataarterienembolisation aus, die langfristig signifikante Verbesserungen der funktionellen Parameter erreichen und dabei mit einem guten Sicherheitsprofil und erhaltener Sexualfunktion \u00fcberzeugen. Vielversprechende Daten liegen auch f\u00fcr das tempor\u00e4r implantierte Nitinoldevice (iTIND), Rez\u016bm, intraprostatische Injektionen von Fexapotid-Triflurtat und die transperineale Laserablation der Prostata vor, deren Effektivit\u00e4t und Sicherheit jedoch noch in weiteren Studien best\u00e4tigt werden m\u00fcssen.<\/jats:p>","DOI":"10.1055\/a-1702-8150","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T23:46:48Z","timestamp":1646178408000},"page":"231-239","source":"Crossref","is-referenced-by-count":0,"title":["Minimal-invasive Therapie: Wie ist der Stand im Jahre 2021 \u2013 was kommt, was geht"],"prefix":"10.1055","volume":"53","author":[{"given":"Julia","family":"Franz","sequence":"additional","affiliation":[{"name":"Medizinische Fakult\u00e4t, Klinik f\u00fcr Urologie, Universit\u00e4tsklinikum Freiburg, Freiburg, 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