{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:23:05Z","timestamp":1792009385347,"version":"4.4.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI Grant","award":["20K08366"],"award-info":[{"award-number":["20K08366"]}]},{"name":"Smoking Research Foundation, Takeda Science Foundation, Grants-in-Aid for Research from the National Center for Global Health and Medicine","award":["19A-2015"],"award-info":[{"award-number":["19A-2015"]}]},{"name":"the Ministry of Health, Labour and Welfare","award":["19HB1003"],"award-info":[{"award-number":["19HB1003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2002Prior studies have shown the effectiveness of both endoscopic band ligation (EBL) and clipping for colonic diverticular hemorrhage (CDH) but have been small and conducted at single centers. Therefore, we investigated which was the more effective and safe treatment in a multicenter long-term cohort study.<\/jats:p><jats:p>\n          Methods\u2002We reviewed data for 1679 patients with CDH who were treated with EBL (n\u200a=\u200a638) or clipping (n\u200a=\u200a1041) between January 2010 and December 2019\u200aat 49 hospitals across Japan (CODE BLUE-J study). Logistic regression analysis was used to compare outcomes between the two treatments.<\/jats:p><jats:p>\n          Results\u2002In multivariate analysis, EBL was independently associated with reduced risk of early rebleeding (adjusted odds ratio [OR] 0.46; P\u200a&lt;\u200a0.001) and late rebleeding (adjusted OR 0.62; P\u200a&lt;\u200a0.001) compared with clipping. These significantly lower rebleeding rates with EBL were evident regardless of active bleeding or early colonoscopy. No significant differences were found between the treatments in the rates of initial hemostasis or mortality. Compared with clipping, EBL independently reduced the risk of needing interventional radiology (adjusted OR 0.37; P\u200a=\u200a0.006) and prolonged length of hospital stay (adjusted OR 0.35; P\u200a&lt;\u200a0.001), but not need for surgery. Diverticulitis developed in one patient (0.16\u200a%) following EBL and two patients (0.19\u200a%) following clipping. Perforation occurred in two patients (0.31\u200a%) following EBL and none following clipping.<\/jats:p><jats:p>\n          Conclusions\u2002Analysis of our large endoscopy dataset suggests that EBL is an effective and safe endoscopic therapy for CDH, offering the advantages of lower early and late rebleeding rates, reduced need for interventional radiology, and shorter length of hospital stay.<\/jats:p>","DOI":"10.1055\/a-1705-0921","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T01:48:50Z","timestamp":1637804930000},"page":"735-744","source":"Crossref","is-referenced-by-count":50,"title":["Effectiveness and adverse events of endoscopic clipping versus band ligation for colonic diverticular hemorrhage: a large-scale multicenter cohort study"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7692-0557","authenticated-orcid":false,"given":"Katsumasa","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyoshi","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Endoscopy, Tokyo Medical University, Tokyo, Japan"},{"name":"Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Furumoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7670-0359","authenticated-orcid":false,"given":"Atsushi","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Omori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ikeya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St. Luke's International University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Saga Medical Center Koseikan, Saga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, St Marianna University School of Medicine, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Kishino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokyo Shinagawa Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunaki","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Nagoya University Hospital, Aichi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinari","family":"Takao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Mizukami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Oita University, Oita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kinjo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Uotani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Japanese Red Cross Shizuoka Hospital, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Fujita","sequence":"additional","affiliation":[{"name":"Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School General Medical Center, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7766-3724","authenticated-orcid":false,"given":"Hiroki","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Center for Digestive Disease and Division of Endoscopy, University of Miyazaki Hospital, Miyazaki, 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band ligation for treatment of colonic diverticular bleeding","volume":"28","author":"S Takahashi","year":"2016","journal-title":"Dig Endosc"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1055\/s-0029-1215179","article-title":"Colonoscopy perforation rate, mechanisms and outcome: from diagnostic to therapeutic colonoscopy","volume":"41","author":"V Panteris","year":"2009","journal-title":"Endoscopy"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1038\/ajg.2010.277","article-title":"Randomized trial of urgent vs. elective colonoscopy in patients hospitalized with lower GI bleeding","volume":"105","author":"L Laine","year":"2010","journal-title":"Am J 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