{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:37:51Z","timestamp":1790170671886,"version":"4.1.0"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This overview analyzes the data on the controversial therapy of iron substitution during pregnancy, the diagnosis of iron deficiency anemia and the indication-related therapy, and is the\n\t\t\t\t\tfirst recommendation issued by the OEGGG on the appropriate therapy. The effects of anemia during pregnancy on postnatal outcomes have been intensively investigated with heterogeneous\n\t\t\t\t\tresults. A final scientific conclusion with regards to the \u201coptimal\u201d maternal hemoglobin level is limited by the heterogeneous results of various studies, many of which were conducted in\n\t\t\t\t\temerging nations (with different dietary habits and structural differences in the respective healthcare systems). The current literature even suggests that there may be a connection between\n\t\t\t\t\tboth decreased and increased maternal serum hemoglobin concentrations and unfavorable short-term and long-term neonatal outcomes. In Austria, 67 percent of pregnant women take\n\t\t\t\t\tpharmacological supplements or use a variety of dietary supplements. Clinically, the prevalence of maternal anemia is often overestimated, leading to overtreatment of pregnant women (iron\n\t\t\t\t\tsubstitution without a medical indication). To obtain a differential diagnosis, a workup of the indications for treatment should be carried out prior to initiating any form of iron\n\t\t\t\t\tsubstitution during pregnancy. If treatment is medically indicated, oral iron substitution is usually sufficient. Because of the restricted approval and potential side effects, medical\n\t\t\t\t\tindications for intravenous iron substitution should be limited. Intravenous iron substitution without a prior detailed diagnostic workup is an off-label use and should only be used in very\n\t\t\t\t\tlimited cases, and women should be advised accordingly.<\/jats:p>","DOI":"10.1055\/a-1710-3387","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T18:45:32Z","timestamp":1649184332000},"page":"392-399","source":"Crossref","is-referenced-by-count":6,"title":["Diagnosis and Therapy of Iron Deficiency Anemia During Pregnancy: Recommendation of the Austrian Society for Gynecology and Obstetrics (OEGGG)"],"prefix":"10.1055","volume":"82","author":[{"given":"Thorsten","family":"Fischer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Paracelsus Medizinische Universit\u00e4t Salzburg (PMU), Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns","family":"Helmer","sequence":"additional","affiliation":[{"name":"Leitliniengruppe der \u00d6sterreichischen Gesellschaft f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Univ.-Klinik f. Frauenheilkunde, Medizinische Universit\u00e4t Wien, Wien, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Klaritsch","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Geburtshilfe, Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Medizinische Universit\u00e4t Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudius","family":"Fazelnia","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Paracelsus Medizinische Universit\u00e4t Salzburg (PMU), Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Bogner","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Paracelsus Medizinische Universit\u00e4t Salzburg (PMU), Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina M.","family":"Hillerer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Paracelsus Medizinische Universit\u00e4t Salzburg (PMU), Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wohlmuth","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Paracelsus Medizinische Universit\u00e4t Salzburg (PMU), Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Jaksch-Bogensperger","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe, Paracelsus Medizinische Universit\u00e4t Salzburg (PMU), Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Board of the Austrian Society for Gynecolgy and Obstetrics (OEGGG)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1007\/s00508-019-1502-9","article-title":"How many women take oral supplementation in pregnancy in Austria?: Who recommended it? A cross-sectional study","volume":"131","author":"U Spary-Kainz","year":"2019","journal-title":"Wien Klin Wochenschr"},{"key":"ref2","first-page":"1","volume-title":"Worldwide prevalence of anaemia 1993 \u2013 2005: WHO Global Database on Anaemia\/Edited by Bruno de Benoist, Erin McLean, Ines Egli and Mary Cogswell","author":"World Health Organization","year":"2008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000117","article-title":"Iron supplementation in pregnancy (Cochrane Review)","author":"K Mahomed","year":"2003","journal-title":"The Cochrane Library"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41430-019-0464-3","article-title":"Anaemia and iron deficiency in pregnancy and adverse perinatal outcomes in Southern India","volume":"74","author":"J L Finkelstein","year":"2020","journal-title":"Eur J Clin 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