{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:56:42Z","timestamp":1792522602109,"version":"4.5.0"},"reference-count":116,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Persistent pulmonary hypertension of the newborn, or PPHN, represents a challenging condition associated with high morbidity and mortality. Management is complicated by complex pathophysiology and limited neonatal specific evidence-based literature, leading to a lack of universal contemporary clinical guidelines for the care of these patients. To address this need and to provide consistent high-quality clinical care for this challenging population in our neonatal intensive care unit, we sought to develop a comprehensive clinical guideline for the acute stabilization and management of neonates with PPHN. Utilizing cross-disciplinary expertise and incorporating an extensive literature search to guide best practice, we present an approachable, pragmatic, and clinically relevant guide for the bedside management of acute PPHN.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1711-0778","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:16:42Z","timestamp":1638404202000},"page":"1495-1508","source":"Crossref","is-referenced-by-count":20,"title":["Evidence-Based Guidelines for Acute Stabilization and Management of Neonates with Persistent Pulmonary Hypertension of the Newborn"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7036-0974","authenticated-orcid":false,"given":"Molly K.","family":"Ball","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio"},{"name":"Division of Neonatology, Nationwide 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Ohio"},{"name":"Division of Neonatology, Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy B.","family":"Schlegel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio"},{"name":"Division of Neonatology, Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Magers","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Kulpa","sequence":"additional","affiliation":[{"name":"Division of Neonatology Nationwide Children's Hospital Neonatal Intensive Care Unit, Neonatal Service Line, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Sharpin","sequence":"additional","affiliation":[{"name":"Division of Neonatology Nationwide Children's Hospital Neonatal Intensive Care Unit, Neonatal Service Line, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Lindsay","family":"Snyder","sequence":"additional","affiliation":[{"name":"Division of Neonatology Nationwide Children's Hospital Neonatal Intensive Care Unit, Neonatal Service Line, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Gajarski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio"},{"name":"Division of Cardiology, Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deipanjan","family":"Nandi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio"},{"name":"Division of Cardiology, Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Carl H.","family":"Backes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio"},{"name":"Division of Neonatology, Nationwide Children's Hospital, Columbus, Ohio"},{"name":"Division of Cardiology, Nationwide Children's Hospital, Columbus, Ohio"},{"name":"Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1542\/peds.81.5.650","article-title":"Hearing loss in infants 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