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While current management is limited to steroids and best supportive care, debate is ongoing concerning liver transplantation for selected patients, and several novel approaches are under way with mixed results. These drawbacks in disease management together with increasing prevalence in Germany, and generally in Western countries, constitute an unmet need for the healthcare systems. This review tries to summarize the current status of these aspects and provides an overview for pathogenesis, management and potential future treatments.<\/jats:p>","DOI":"10.1055\/a-1713-3796","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T18:38:34Z","timestamp":1642531114000},"page":"67-76","source":"Crossref","is-referenced-by-count":4,"title":["Severe alcoholic hepatitis as precipitant for organ failure and ACLF"],"prefix":"10.1055","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-3881","authenticated-orcid":false,"given":"Jonel","family":"Trebicka","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1, University of Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Louvet","sequence":"additional","affiliation":[{"name":"H\u00f4pital Huriez Service de Medecine Interne, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Arroyo","sequence":"additional","affiliation":[{"name":"European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Jalan","sequence":"additional","affiliation":[{"name":"University College London, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0862-403X","authenticated-orcid":false,"given":"Richard","family":"Moreau","sequence":"additional","affiliation":[{"name":"H\u00f4pital Beaujon, Clichy, 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